Factores metabólicos en la población escolar asociados a mortalidad cardiovascular en los adultos. Estudio Cuatro Provincias

Perfil lipídico y sus características entre la población infantil

“…Uno de los principales estudios orientados en nuestro país al análisis de los factores de riesgo cardiovascular en niños ha sido el estudio Cuatro Provincias 7 . Dicho estudio se llevó a cabo en una población de niños prepuberales pertenecientes a cuatro provincias, analizando sus valores plasmáticos lipídicos.…”

Lipid and lipoprotein concentrations at age 4. Association with neonatal and parental levels

“…Such grouping responds to traditional classifications in which neonates with normal cholesterol levels were compared to neonates with high cholesterol levels 11 . Moreover, it takes into consideration the fact that other cardiovascular risk markers -such as high triglyceride and Apo B levels and low high density lipoproteins-cholesterol (HDLc) and Apo A1 levels-appear involved in coronary artery disease 12,13 or in metabolic syndrome 6,14 . The cut-off points used for male neonates were as follows: TC ≥ 2.59 mmol/l or ≥ 100 mg/dl; triglycerides ≥ 0.89 mmol/l or ≥ 79.2 mg/dl; low densitiy lipoproteins-cholesterol (LDLc) ≥ 1.45 mmol/l or ≥ 56.1 mg/dl; HDLc ≤ 0.45 mmol/l or ≤ 17.5 mg/dl; Apo B ≥ 0.45 g/l; Apo A1 ≤ 0.51 g/l; TC/HDLc ≥ 3.88; Apo A1/Apo B ratio ≤ 1.68.…”

“…However, to the best of our knowledge, neonatal lipoprotein values have not been used as baseline values in follow-up studies in Spain. Total serum cholesterol (TC) concentrations in Spanish children have increased over the last few decades and they are already at very high levels 6,7 . Diet, among other factors, has been suggested to play a relevant effect 6 .…”

“…Total serum cholesterol (TC) concentrations in Spanish children have increased over the last few decades and they are already at very high levels 6,7 . Diet, among other factors, has been suggested to play a relevant effect 6 . Moreover, some metabolic syndrome markers are also very prevalent in Spanish children 6 .…”

“…Diet, among other factors, has been suggested to play a relevant effect 6 . Moreover, some metabolic syndrome markers are also very prevalent in Spanish children 6 . These findings suggest that preventive measures should be taken early in life.…”