Factores pronósticos del traumatismo craneoencefálico grave

Bernal, Ernesto; Rubio-Gil, Francisco; Corral, Jorge; Prieto, Laura; Robledo, J. González

doi:10.1016/j.medin.2012.05.015

Cited by 16 publications

(3 citation statements)

References 24 publications

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“…Because intracerebral bleeding is a major cause of mortality and morbidity in ICH patients, timely intervention is critical for saving lives and for better outcomes of the patients. P. notoginseng is a hemostatic drug that has been used to stop bleeding after gun-shots and traumatic injuries since the Ming Dynasty ( 93 ). The non-protein amino acid dencichine and notoginsenoside Ft1 of PNS have been identified as the active hemostatic components of P. notoginseng ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action

Huang

et al. 2015

Front. Neurol.

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Intracranial/intracerebral hemorrhage (ICH) is a leading cause of death and disability in people with traumatic brain injury (TBI) and stroke. No proven drug is available for ICH. Panax notoginseng (total saponin extraction, PNS) is one of the most valuable herb medicines for stroke and cerebralvascular disorders in China. We searched for randomized controlled clinical trials (RCTs) involving PNS injection to treat cerebral hemorrhage for meta-analysis from various databases including the Chinese Stroke Trials Register, the trials register of the Cochrane Complementary Medicine Field, the Cochrane Central Register of Controlled Trials, MEDLINE, Chinese BioMedical disk, and China Doctorate/Master Dissertations Databases. The quality of the eligible trials was assessed by Jadad’s scale. Twenty (20) of the 24 identified randomized controlled trials matched the inclusive criteria including 984 ICH patients with PNS injection and 907 ICH patients with current treatment (CT). Compared to the CT groups, PNS-treated patients showed better outcomes in the effectiveness rate (ER), neurological deficit score, intracranial hematoma volume, intracerebral edema volume, Barthel index, the number of patients died, and incidence of adverse events. Conclusion: PNS injection is superior to CT for acute ICH. A review of the literature shows that PNS may exert multiple protective mechanisms against ICH-induced brain damage including hemostasis, anti-coagulation, anti-thromboembolism, cerebral vasodilation, invigorated blood dynamics, anti-inflammation, antioxidation, and anti-hyperglycemic effects. Since vitamin C and other brain cell activators (BCA) that are not considered common practice were also used as parts of the CT in several trials, potential PNS and BCA interactions could exist that may have made the effect of PNS therapy less or more impressive than by PNS therapy alone. Future PNS trials with and without the inclusion of such controversial BCAs as part of the CT could clarify the situation. As PNS has a long clinical track record in Asia, it could potentially become a therapy option to treat ICH in the US and Europe. Further clinical trials with better experimental design could determine the long-term effects of PNS treatment for TBI and stroke.

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Section: Discussionmentioning

confidence: 99%

“…Hyperglycemia is associated with poor outcome in patients with TBI and ICH and in experimental models of ICH ( 93 , 168 , 169 ). PNS has hypolipidemic and antioxidant activities in rats with high-fat diets ( 170 ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action

Huang

et al. 2015

Front. Neurol.

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“…Las alteraciones pupilares son otro de los factores asociados a la mortalidad (Jain 2008, Frutos 2012, existiendo trabajos en los que se proponen scores pronósticos con la asociación de alteración pupilar y GCS para predecir la mortalidad (Hoffman 2012). En nuestro estudio las alteraciones pupilares tienen una incidencia menor que en la de los estudios mencionados anteriormente probablemente relacionado con la selección de pacientes, aunque su relación con la mortalidad es muy significativa.…”

Section: Viii511-clasificación Y Factores De Gravedad En El Traumaunclassified

Atención al paciente traumatizado grave y politraumatizado en una unidad de cuidados intensivos de la provincia de Salamanca

Robledo¹

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Association Between DNA and RNA Oxidative Damage and Mortality of Patients with Traumatic Brain Injury

et al. 2019

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Factores pronósticos del traumatismo craneoencefálico grave

Cited by 16 publications

References 24 publications

Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action

Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action

Atención al paciente traumatizado grave y politraumatizado en una unidad de cuidados intensivos de la provincia de Salamanca

Association Between DNA and RNA Oxidative Damage and Mortality of Patients with Traumatic Brain Injury

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