Factors affecting blood sample haemolysis

Barnard, Ed; Potter, David; Ayling, Ruth M; Higginson, Ian; Bailey, Andrew; Smith, Jessi L.

doi:10.1097/mej.0000000000000195

Cited by 12 publications

(19 citation statements)

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“…Two studies (Grant, ; Ong et al, ) found that the use of a vacutainer compared with syringe resulted in higher PIVC haemolysis rates and one study (Phelan et al, ) found no differences. Three studies (Barnard et al, ; Phelan et al, ; Wollowitz et al, ) found blood drawn from the antecubital fossa were less likely to be haemolysed when compared with blood drawn from other sites, in contrast to another study (Lowe et al, ) who found no differences related to blood draw site. Two studies (Phelan et al, ; Wollowitz et al, ) found that the use of larger gauge needles were less likely to have haemolysed samples compared with a smaller gauge needle, in contrast to another study by Ong et al, who found no differences related to needle gauge size.…”

Section: Resultsmentioning

confidence: 98%

“…The same study (Wollowitz et al, ) also found that the blood samples were more likely to be haemolysed if the blood collection tube was less than half full. Two studies (Phelan et al, ; Wollowitz et al, ) found if the tourniquet time was greater than 1 min blood samples were more likely to be haemolysed with one study (Barnard et al, ) finding no differences. Two studies (Barnard et al, ; Wollowitz et al, ) found blood samples were more likely to be haemolysed if the venepuncture was difficult (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The 16 studies were critically appraised (Table 2) The aims of the studies can be summarized as firstly to: examine blood sample haemolysis rates between blood samples drawn via venepuncture compared with PIVC (Barnard et al, 2016;Corbo et al, 2007;Dietrich, 2014;Grant, 2003;Lowe et al, 2008;Munnix et al, 2010;Ong et al, 2008;Ortells-Abuye et al, 2014;Phelan et al, 2018;Seemann & Reinhardt, 2000;Wollowitz et al, 2013;Zlotowski et al, 2001). Secondly, to examine equivalence of blood test results between blood samples drawn via PIVC compared with venepuncture (Corbo et al, 2007;Hambleton et al, 2014;Himberger & Himberger, 2001;Ortells-Abuye et al, 2014;Zlotowski et al, 2001).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Drawing blood from peripheral intravenous cannula compared with venepuncture: A systematic review and meta‐analysis

Coventry

Jacob

Davies

et al. 2019

Journal of Advanced Nursing

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Aims To synthesize the evidence evaluating if blood samples are similar when obtained from peripheral intravenous cannula compared with venepuncture. Design A systematic review and meta‐analysis was undertaken. Data sources Searches were conducted in databases for English language studies between January 2000–December 2018. Review methods The search adhered to the Meta‐analysis of Observational Studies in Epidemiology guidelines. The methodological quality of studies was assessed using Joanna Briggs critical appraisal instruments. The overall quality of the evidence was assessed using the GRADE. Results Sixteen studies were identified. Findings suggest haemolysis rates are higher in blood sampled from peripheral intravenous cannula. However, haemolysis rates may be lower if a peripheral intravenous cannula blood sampling protocol is followed. For equivalence of blood test results, even though some results were outside the laboratory, allowable error and were outside the Bland–Altman Level of Agreement, none of these values would have required clinical intervention. With regard to the contamination rates of blood cultures, the results were equivocal. Conclusion Further research is required to inform the evidence for best practice recommendations, including, if a protocol for drawing blood from a peripheral cannula is of benefit for specific patient populations and in other settings. Impact Venepuncture can provoke pain, anxiety and cause trauma to patients. Guidelines recommend blood samples from peripheral intravenous cannula be taken only on insertion. Anecdotal evidence suggests drawing blood from existing cannulas may be a common practice. Further research is required to resolve this issue.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Drawing blood from peripheral intravenous cannula compared with venepuncture: A systematic review and meta‐analysis

Coventry

Jacob

Davies

et al. 2019

Journal of Advanced Nursing

View full text Add to dashboard Cite

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“…Similar observations were published by Blazys (1999) and Becan-McBride (1999). A study by Barnard et al (2016) found that the device type used to obtain a sample was a significant factor in the haemolysis rate, with sampling via an intravenous catheter associated with a significant increase in likelihood compared to sampling with a needle.…”

Section: Venepuncture Procedures Analysismentioning

confidence: 99%

“…The literature review identified that another key variable that might influence procedure outcomes was the device type used to obtain the sample, e.g. Jagger et al (1988) and Barnard et al (2016). The questionnaire included a question on the types of needle used and associated estimated probability of successful blood sample collection and needle stick injury risk.…”

Section: Venepuncture Procedures Analysismentioning

confidence: 99%

Effect of venepuncture process design on efficiency and failure rates: A simulation model study for secondary care

Reed

Remenyte‐Prescott

Rees

2017

International Journal of Nursing Studies

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Reed, Sean and Remenyte-Prescott, Rasa and Rees, Ben (2017) Effect of venepuncture process design on efficiency and failure rates: a simulation model study for secondary care. International Journal of Nursing Studies,[68][69][70][71][72][73][74][75][76][77][78][79][80][81][82] Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/41154/1/Effect%20of%20Venepuncture%20process %20design%20on%20efficiency%20and%20failure.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk Effect of venepuncture process design on efficiency and failure rates: a simulation model study for secondary care AbstractBackground: Healthcare aims to deliver good patient outcomes. For many clinical procedures there are multiple alternative task sequences that can be performed. These deviations can influence procedure reliability, efficiency of usage of hospital resources and risk to staff and patient safety. Venepuncture is one of the most common invasive procedures in healthcare. Literature of clinical practice shows evidence of wide variability in the procedure order and the duration of each step, which can depend on attributes, such as patient health, sampling method and staff skills.Objective: To use a computer simulation model based on Petri nets to evaluate the impact on outcomes of commonly practiced deviations from the guideline venepuncture procedure and variations in key dependent variables. The outcomes considered include the probability of successfully obtaining a blood sample and the procedure completion time.Design: A computer simulation model was constructed using the Petri net technique which mimics the different variations of the venepuncture procedure. Qualitative and quantitative data for the model was collected from the literature and through interviews and questionnaire responses from doctors and phlebotomists. Statistics on the reliability and duration for different variations were then calculated from the model output.Setting: A digital laboratory to model venepuncture in secondary care.Results: The model showed that the common practice of applying the tourniquet prior to vein identification and releasing it after sample tubes are filled may result in a ten-fold increase in sample haemolysis, compared to the recommended guideline procedure. Equipment la...

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Blood venous sample collection: Recommendations overview and a checklist to improve quality

Giavarina

Lippi

2017

Clinical Biochemistry

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Factors affecting blood sample haemolysis

Cited by 12 publications

References 0 publications

Drawing blood from peripheral intravenous cannula compared with venepuncture: A systematic review and meta‐analysis

Drawing blood from peripheral intravenous cannula compared with venepuncture: A systematic review and meta‐analysis

Effect of venepuncture process design on efficiency and failure rates: A simulation model study for secondary care

Blood venous sample collection: Recommendations overview and a checklist to improve quality

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