This study aims to measure the impact of factors on the loyalty of employees at small and medium enterprises (SMEs) in Ho Chi Minh City through interviews with 640 surveys with a non-probability sampling method, a convenient approach. Quantitative analysis techniques used in the study include reliability analysis of the scale through Cronbah's Alpha index, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), and structural equation modeling (SEM). From the results of SEM analysis of the whole model, it is shown that the fit of the tested model is relatively high, satisfying the conditions with p-value = 0.000 < 0.05. Besides, the SEM analysis results also show that independent factors (1) Opportunities for training and resource development; (2) Direct employee involvement; (3) Support from superiors and colleagues; (4) Environment and working conditions; (5) Salary, allowances, and benefits; (6) Fair rewards; (7) Alignment with organizational goals; (8) Level of empowerment; have a positive impact on employee job satisfaction at 1% significance level. At the same time, the job satisfaction factor in the employee's work positively impacts employees' loyalty to the organization at the 1% significance level. Accordingly, independent factors explain 72.10% of the change in job satisfaction in the employee's work; the remaining 37.90% of the change is explained by other factors. In addition, job satisfaction in employees' work explained 63.1% of the shift in employee loyalty to the organization, and 36.9% of the change was explained by factors other than the model. From the research results, the authors proposed managerial implications to increase the loyalty of employees in SMEs. Finally, the study contributions help enterprise managers improve qualitatively, and obstacles to implementing the above 8 factors have been assessed.