Factors affecting mortality of neonatal sepsis in Moewardi Hospital, Surakarta

Hafidh, Yulidar; Hidayah, Dwi; Sunyataningkamto, Sunyataningkamto

doi:10.14238/pi47.2.2007.74-7

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…In our study, the gestational age variable had p<0.250, then multivariate analysis was carried out using logistic regression but no significant differences were found. This is in line with research conducted at RSUD Dr. Moewardi previously by Hafidh et al (2007) where no significant differences were found in gender and culture growth (Hafidh, 2007). In Rasyida et al (2023) research, significant differences were found where gram-negative bacteria were a predictor of mortality and had an OR of 4.821 (95% CI= 10.18 to 22.842) (Rasyida et al, 2023).…”

Section: Discussionsupporting

confidence: 81%

Delta Neutrophil Index and C-Reactive Protein as Predictors of Mortality in Early Onset Neonatal Sepsis at Dr. Moewardi Hospital

Deaneva,

Siregar,

Martuti

2024

J Matern Child Health

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Background: Neonatal sepsis is an infection disease in newborns that still be a major problem in developing countries such as Indonesia. Early onset sepsis has higher mortality and morbidity. A simple and applicable biomarkers are needed to predict mortality in early onset neonatal sepsis. This study aimed to investigate whether Delta Neutrophil Index (DNI) and C-Reactive Protein (CRP) can be used as predictors of mortality in early onset neonatal sepsis. Subjects and Method: A cohort study that was conducted at neonatal HCU and NICU at Dr. Moewardi Hospital from March to June 2023. Total of 30 neonates aged 0-72 hours which met the inclusion criteria and became research subjects. The dependent variable was the mortality of neonatal sepsis. The independent variable were levels of DNI and CRP values. The instruments were flowcytometry to measure levels of DNI and Enzyme Linked Immunoassay (ELISA) for determining CRP values. Data were analyzed using SPSS 25.0. Bivariate analysis was using Chi square and Fisher exact followed by multivariate analysis using logistic regression with p<0.05. Results: Thirty early onset septic neonates were included in study, of whom 17 children died and 13 children survived. Both DNI and CRP had significant correlation with mortality of neonatal sepsis (p<0.001). The DNI cut-off value of ≥ 5.4% (OR = 10.83; 95% CI 1.96 to 59.63; p = 0.004) can predict mortality in early onset neonatal sepsis. The CRP cut-off values of ≥5.75 mg/L (OR = 15.56; 95%CI 2.59 to 93.57; p = 0.001) could predict early onset neonatal sepsis mortality. Other factors such as gender, gestational age, birth weight and blood culture couldn’t be used as predictors of mortality in neonatal sepsis, with p value >0.05. Conclusion: DNI and CRP could be used as predictors of mortality in early onset neonatal sepsis. Keywords: clean and healthy living behavior, diarrhea, toddlers. Correspondence: Almira Muthia Deaneva. Department of Pediatrics, Sebelas Maret University/Dr. Moewardi General Hospital, Surakarta, Central Java, Indonesia. Kolonel Sutarto Street No. 132, Surakarta, Indonesia. email: almiradea@gmail.com Phone: 081215822020.

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Section: Discussionsupporting

confidence: 81%

Delta Neutrophil Index and C-Reactive Protein as Predictors of Mortality in Early Onset Neonatal Sepsis at Dr. Moewardi Hospital

Deaneva,

Siregar,

Martuti

2024

J Matern Child Health

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“…The association of prematurity with mortality in neonatal sepsis may be due to deficiencies in humoral and cellular immunity. Premature infants have extremely low immunoglobulin levels (except for IgG) to specific maternal antigens, since those immunoglobulins are passively transferred across the placenta in the last trimester of pregnancy [ 14 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Sepsis at a Teaching Hospital in Bayelsa State, Nigeria

Peterside¹,

Pondei

Akinbami³

2015

Trop.Med.Health

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Background: Sepsis is one of the most common causes of neonatal hospital admissions and is estimated to cause 26% of all neonatal deaths worldwide. While waiting for results of blood culture, it is necessary to initiate an empirical choice of antibiotics based on the epidemiology of causative agents and antibiotic sensitivity pattern in a locality. Objective: To determine the major causative organisms of neonatal sepsis at the Niger Delta University Teaching Hospital (NDUTH), as well as their antibiotic sensitivity patterns, with the aim of formulating treatment protocols for neonates. Methods: Within a 27-month period (1st of October 2011 to the 31st of December 2013), results of blood culture for all neonates screened for sepsis at the Special Care Baby Unit of the hospital were retrospectively studied. Results: Two hundred and thirty-three (49.6%) of the 450 neonates admitted were screened for sepsis. Ninety-seven (43.5%) of them were blood culture positive, with 52 (53.6%) of the isolated organisms being Gram positive and 45 (46.4%) Gram negative. The most frequently isolated organism was Staphylococcus aureus (51.5%) followed by Escherichia coli (16.5%) and Klebsiella pneumoniae (14.4%). All isolated organisms demonstrated the highest sensitivity to the quinolones. Conclusion: Neonatal sepsis is a significant cause of morbidity among neonates admitted at the NDUTH. There is a need for regular periodic surveillance of the causative organisms of neonatal sepsis as well as their antibiotic susceptibility pattern to inform the empirical choice of antibiotic prescription while awaiting blood culture results.

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“…8 Hasil serupa dilaporkan di Rumah Sakit Moewardi Surakarta yang menemukan bahwa angka kematian sepsis neonatus 40%. 18 Perbedaan dalam tingkat kematian pada sepsis neonatus antar negara dapat dijelaskan oleh berbagai faktor, antara lain faktor ekonomi, geografis dan sosial rasial, penggunaan ventilator, inkubator, dan mikroorganisme yang berbeda serta penggunaan antibiotik yang berbeda. 2,4,5 Dalam penelitian kami, sebagian besar kasus kematian disebabkan karena neonatus yang memiliki indikasi perawatan UPIN tidak dapat dirawat, karena kapasitas yang terbatas.…”

Section: Pembahaanunclassified

Insiden dan Faktor-Faktor yang Berhubungan dengan Sepsis Neonatus di RSUP Sanglah Denpasar

Putra

2016

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Factors affecting mortality of neonatal sepsis in Moewardi Hospital, Surakarta

Abstract: N eonatal sepsis is still a significant prob lem found both in developing and de veloped countries. Even though there has been advance in therapy, the morbidity and the mortality are still high. The total of sepsis cases in developing countries is 1.8-18/1000 of birth ABSTRACT

Cited by 4 publications

References 9 publications

Delta Neutrophil Index and C-Reactive Protein as Predictors of Mortality in Early Onset Neonatal Sepsis at Dr. Moewardi Hospital

Delta Neutrophil Index and C-Reactive Protein as Predictors of Mortality in Early Onset Neonatal Sepsis at Dr. Moewardi Hospital

Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Sepsis at a Teaching Hospital in Bayelsa State, Nigeria

Insiden dan Faktor-Faktor yang Berhubungan dengan Sepsis Neonatus di RSUP Sanglah Denpasar

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