Factors affecting MS patients’ health-related quality of life and measurement challenges in Lebanon and the MENA region

Farran, Natali; Safieddine, Batoul; Bayram, Mariam; Hanna, Tracy Abi; Massouh, Joelle; AlKhawaja, Mona; Tamim, Hani; Darwish, Hala

doi:10.1177/2055217319848467

Cited by 17 publications

(22 citation statements)

References 56 publications

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“…In our study, the highest self-rated quality of life concerned RFa (81.37), RFr (69.83), and REJ (69.04) domains. In contrast, the lowest quality of life was reported regarding COP (51.72) and PWB (55.67), which is consistent with the results obtained by Koltuniuk et al 79 among female MS patients and Farran et al 76 On the other hand, in the validation study of the Polish version of the MusiQoL questionnaire, MS patients scored significantly lower on average – 42.5 points, and they rated their quality of life highest in terms of SPT and lowest in RFa. This difference is likely because all patients included in our study suffered from RRMS and were participating in a drug program that translates into better functional ability and the capacity to participate in family and work-life more actively.…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies have also shown a link between socio-demographic variables and specific domains of quality of life in MS patients. 64 , 76 , 77 For instance, age is negatively correlated with the MusiQoL total score, 76 which was also confirmed in our study. Jamroz-Wisniewska et al 64 and Nickel et al 77 showed that males rated the quality of life in PWB higher than females, which was also confirmed by our study.…”

Section: Discussionsupporting

confidence: 88%

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The Role of Stress Perception and Coping with Stress and the Quality of Life Among Multiple Sclerosis Patients

Kołtuniuk

Kazimierska-Zając

Cisek

et al. 2021

PRBM

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Purpose Multiple sclerosis (MS) is one of the most common neurological disorders and a cause of disability in young adults. Adequate stress management in MS patients may merit the benefits of both physical and psychological well-being. This study aimed to evaluate the quality of life in MS patients and its correlation with stress levels and coping strategies. Methods This descriptive and correlational study was conducted among 109 patients diagnosed with relapsing-remitting MS (RRMS). The study was based on a questionnaire designed by the authors and the following standardized questionnaires: the Perceived Stress Scale (PSS-10), the Inventory for Measuring Coping with Stress (Mini-COPE), and the Multiple Sclerosis International Quality of Life Questionnaire (MusiQoL). Results Data analysis showed that 47.71% of the patients experienced a high level of stress, and the most often used strategies under challenging situations included seeking emotional support (2.11) and active coping (1.96). Also, it showed that when the level of stress is higher, the QOL in all domains is lower. Coping strategies such as sense of humor, turning to religion, self-distraction, denial, venting, substance use, behavioral disengagement, and self-blame are negatively correlated with the quality of life of MS. Conclusion Quality of life in MS patients is negatively affected by a higher level of perceived stress. The use of coping strategies such as active coping, positive reframing, acceptance, and seeking emotional and instrumental support is positively correlated with the quality of life of MS patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

The Role of Stress Perception and Coping with Stress and the Quality of Life Among Multiple Sclerosis Patients

Kołtuniuk

Kazimierska-Zając

Cisek

et al. 2021

PRBM

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“…Indeed, there was a statistically significant inverse relationship between change in EDSS score over time and change in MusiQoL total score, with a 1-point increase in EDSS score associated with a 1.44 ( p = 0.0003) point decrease in MusiQoL total score. These observations were similar to a study assessing HRQoL in the Middle East and North Africa region which found that a higher EDSS scores was associated with a lower MusiQoL score [ 9 ].…”

Section: Discussionsupporting

confidence: 89%

“…At baseline, the mean MusiQoL total score was 65.67 ± 0.8 demonstrating that overall, the patients' mostly assessed their quality of life positively. These positive perceptions of HRQoL were also observed in a MusiQoL study conducted in Lebanon [ 9 ].…”

Section: Discussionsupporting

confidence: 64%

A Prospective Multicenter Study for Assessing MusiQoL Validity among Arabic-Speaking MS Patients Treated with Subcutaneous Interferon β-1a

Aljumah

Kojan

Alroughani

et al. 2021

Multiple Sclerosis International

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Few studies examine health-related quality of life (HRQoL) in Arabic-speaking multiple sclerosis (MS) patients. However, HRQoL tools such as the Short Form-36 QoL instrument (SF-36) and the Multiple Sclerosis International QoL (MusiQoL) questionnaire have been validated in other languages. The primary objective of this study was to prospectively assess HRQoL using the MusiQoL questionnaire among Arabic-speaking MS patients treated with subcutaneous interferon (sc IFN β-1a) over 12 months, as part of a prospective, multinational, multicenter cohort study. Patients’ clinical parameters and HRQoL were assessed at baseline, 6 months, and 12 months. Changes in MusiQoL total and subdomain scores were compared using a Friedman test. Correlation between MusiQoL total score and Expanded Disability Status Score (EDSS) was also evaluated. In total, 439 patients from four Arabic-speaking countries were included. The mean age was 32.44 (±0.34) years, 71.5% were female, and 63.1% had an education level of university or above. The mean MS duration was 4.13 (±0.12) years, mean age at first attack was 27.35 (±0.26) years, and mean baseline EDSS score was 2.05 (±0.04). MusiQoL total score significantly improved at 6 months; however, this diminished at 12 months ( 65.67 ± 0.8 at baseline vs. 67.21 ± 0.79 at 6 months and 65.75 ± 0.8 at 12 months; p = 0.0015 ). Several aspects of patients’ HRQoL including activity of daily living, physical well-being, symptoms, and coping improved. Overall HRQoL measured using SF-36 remained generally unchanged over time ( p = 0.215 ). There was a statistically significant inverse relationship between change in EDSS score over time and change in overall MusiQoL score over time. In summary, findings confirm the utility of using MusiQoL for assessing changes in HRQoL during treatment with sc IFN β-1a in Arabic-speaking patients with MS.

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“…Adapting and validating questionnaires for the measurement of quality of life or fatigue is an area of active development as reported by Farran et al, 17 in which the authors were able to validate the Arabic multiple sclerosis international quality of life (MusiQoL) and modified fatigue impact scale (MFIS). Their data showed that quality of life was impacted by psychosocial fatigue in addition to age and disease type.…”

mentioning

confidence: 99%

Multiple sclerosis in the Middle East and North Africa region

Khoury

Tintoré

2020

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Factors affecting MS patients’ health-related quality of life and measurement challenges in Lebanon and the MENA region

Cited by 17 publications

References 56 publications

The Role of Stress Perception and Coping with Stress and the Quality of Life Among Multiple Sclerosis Patients

The Role of Stress Perception and Coping with Stress and the Quality of Life Among Multiple Sclerosis Patients

A Prospective Multicenter Study for Assessing MusiQoL Validity among Arabic-Speaking MS Patients Treated with Subcutaneous Interferon β-1a

Multiple sclerosis in the Middle East and North Africa region

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