Factors Affecting Survival Among Women with Breast Cancer in Hawaii

Maskarinec, Gertraud; Pagano, Ian; Lurie, Galina; Bantum, Erin O’Carroll; Gotay, Carolyn; Issell, Brian F.

doi:10.1089/jwh.2010.2114

Cited by 27 publications

(41 citation statements)

References 31 publications

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“…This is likely because all-cause mortality includes breast cancer mortality and non-breast cancer mortality. Our results for NHW women are consistent with reports from meta-analyses [23][24][25] and other studies 1,3,5,7,10,26 that indicate an increased risk for breast cancer mortality in obese compared to nonobese women, with HRs ranging from 1.2 to 3.0. However, few of these previous studies investigated ethnic differences, particularly between Hispanic and NHW women, in the associations of obesity and breast cancer survival.…”

Section: Discussionsupporting

confidence: 92%

Obesity and Risk of Breast Cancer Mortality in Hispanic and Non-Hispanic White Women: The New Mexico Women's Health Study

Connor

Baumgartner

Pinkston

et al. 2013

Journal of Women's Health

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Obesity is reported to be associated with poorer survival in women with breast cancer, regardless of menopausal status. Our purpose was to determine if the associations of obesity with breast cancer-specific, all-cause, and non-breast cancer mortality differ between Hispanic and non-Hispanic white (NHW) women with breast cancer. Data on lifestyle and medical history were collected for incident primary breast cancer cases (298 NHW, 279 Hispanic) in the New Mexico Women's Health Study. Mortality was ascertained through the National Death Index and New Mexico Tumor Registry over 13 years of follow-up. Adjusted Cox regression models indicated a trend towards increased risk for breast cancer-specific mortality in obese NHW women (hazard ratio [HR] 2.07; 95% confidence interval [CI] 0.98-4.35) but not in Hispanic women (HR 1.32; 95% CI 0.64-2.74). Obese NHW women had a statistically significant increased risk for all-cause mortality (HR 2.12; 95% CI 1.15-3.90) while Hispanic women did not (HR 1.23; 95% CI 0.71-2.12). Results were similar for non-breast cancer mortality: NHW (HR 2.65; 95% CI 0.90-7.81); Hispanic (HR 2.18; 95% CI 0.77-6.10). Our results suggest that obesity is associated with increased risk for breast cancer-specific mortality in NHW women; however, this association is attenuated in Hispanic women.

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Section: Discussionsupporting

confidence: 92%

Obesity and Risk of Breast Cancer Mortality in Hispanic and Non-Hispanic White Women: The New Mexico Women's Health Study

Connor

Baumgartner

Pinkston

et al. 2013

Journal of Women's Health

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“…Breast cancers diagnosed as invasive ductal carcinomas during this period received a common regimen of chemotherapy and antihormonal therapies. 41 Development of high grade toxicity, 41,42 owing in part to combination treatment chemotherapy to tamoxifen, was shown to be associated with poor patient prognosis. 41 Obesity is another factor affecting chemotherapeutic efficacy and patient outcome; obese patients tend to be undertreated.…”

Section: Discussionmentioning

confidence: 99%

“…Luminal A breast cancers were identified as ER+ and/or PR+, Her2 − and low Chemokine expression in breast cancer Ki67 (o 14%) or mitotic index ( o 2). Luminal B breast cancers were defined by the expression of ER and/or PR, expression of Her2+ and high Ki67 (414%) or mitotic index (42). Her2+ breast cancers were identified as ER − , PR − and strongly Her2+, while basal-like breast cancers were defined by the absence of ER, PR and Her2 expression.…”

Section: Stromal Ccl2 Associates With Decreased Relapse-free Survivalmentioning

confidence: 99%

Elevated expression of chemokine C-C ligand 2 in stroma is associated with recurrent basal-like breast cancers

Yao

Staggs

et al. 2016

Modern Pathology

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Despite advances in treatment, up to 30% of breast cancer patients experience disease recurrence accompanied by more aggressive disease and poorer prognosis. Treatment of breast cancer is complicated by the presence of multiple breast cancer subtypes, including: luminal, Her2 overexpressing, and aggressive basal-like breast cancers. Identifying new biomarkers specific to breast cancer subtypes could enhance the prediction of patient prognosis and contribute to improved treatment strategies. The microenvironment influences breast cancer progression through expression of growth factors, angiogenic factors and other soluble proteins. In particular, chemokine C-C ligand 2 (CCL2) regulates macrophage recruitment to primary tumors and signals to cancer cells to promote breast tumor progression. Here we employed a software-based approach to evaluate the prognostic significance of CCL2 protein expression in breast cancer subtypes in relation to its expression in the epithelium or stroma or in relation to fibroblast-specific protein 1 (Fsp1), a mesenchymal marker. Immunohistochemistry analysis of tissue microarrays revealed that CCL2 significantly correlated with Fsp1 expression in the stroma and tumor epithelium of invasive ductal carcinoma. In the overall cohort of invasive ductal carcinomas (n = 427), CCL2 and Fsp1 expression in whole tissues, stroma and epithelium were inversely associated with cancer stage and tumor size. When factoring in molecular subtype, stromal CCL2 was observed to be most highly expressed in basal-like breast cancers. By Cox regression modeling, stromal CCL2, but not epithelial CCL2, expression was significantly associated with decreased recurrence-free survival. Furthermore, stromal CCL2 (HR = 7.51 P = 0.007) was associated with a greater hazard than cancer stage (HR = 2.45, P = 0.048) in multivariate analysis. These studies indicate that stromal CCL2 is associated with decreased recurrence-free survival in patients with basal-like breast cancer, with important implications on the use of stromal markers for predicting patient prognosis.

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“…Compliance and persistence with medical measures are strongly determined by personal motivations, which are determined by a considerable number of individual psychosocial and medical factors. Few published studies have evaluated the impact of body weight on compliance and persistence with BC therapy [2,24,25,26]. However, the complex relationship between BMI and acceptance of medical measures has been rather well examined with regards to mammography screening rates.…”

Section: Discussionmentioning

confidence: 99%

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

Eichholzer

Huang²,

Modlasiak³

et al. 2013

Breast Care

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Background: This study analyzes the association of body mass index (BMI) and prognostically relevant breast cancer (BC) characteristics in a country that has been rather spared of the global obesity epidemic. Patients and Methods: Based on 20-year data (1999-2009, n = 1,414) of the prospective relational BC database of the University Hospital Basel, Switzerland, the associations between BMI, tumor size and stage, histological subtype, grading, hormonal receptor status, HER2 status and ‘triple-negative' status were evaluated. Multivariate analysis considered BMI and patient's age. Results: The association between increasing BMI and the above-mentioned variables were as follows (results described in each case: Beta-coefficient or odds ratio, 95% confidence interval, p value): tumor size, (1) entire cohort: 0.03 (0.01-0.05), p < 0.001, (2) tumor found by self-palpation: 0.05 (0.03-0.07), p < 0.001, (3) tumor found by radiological examination: 0.03 (0-0.07), p = 0.044; advanced TNM stage: 1.16 (1.02-1.31), p = 0.022; histological subtype: 1.04 (0.89-1.22), p = 0.602; unfavorable grading: 1.11 (1.00-1.25), p = 0.057; positive estrogen receptor status: 0.95 (0.83-1.09), p = 0.459; positive HER2 status: 0.92 (0.74-1.15), p = 0.467; presence of a ‘triple-negative' carcinoma: 1.19 (0.93-1.52), p = 0.165. Consideration of only postmenopausal BC patients (n = 1,063) did attenuate the results, but did not change the direction of the associations with BMI. Conclusion: BMI was positively associated with TNM stage, grading and tumor size for tumors that were found by self-detection, as well as for those lesions detected by radiological breast examinations.

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Factors Affecting Survival Among Women with Breast Cancer in Hawaii

Cited by 27 publications

References 31 publications

Obesity and Risk of Breast Cancer Mortality in Hispanic and Non-Hispanic White Women: The New Mexico Women's Health Study

Obesity and Risk of Breast Cancer Mortality in Hispanic and Non-Hispanic White Women: The New Mexico Women's Health Study

Elevated expression of chemokine C-C ligand 2 in stroma is associated with recurrent basal-like breast cancers

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

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