Factors affecting the clinical outcome of bluetongue virus infection in adult mice

Saminathan, Mani; Vineetha, S.; Maity, Madhulina; Biswas, Sanchay Kumar; Reddy, G.B. Manjunatha; Milton, Arockiasamy Arun Prince; Chauhan, H.C.; Chandel, B.S.; Ramakrishnan,; Gupta, Vandana

doi:10.5958/0973-970x.2018.00057.3

Cited by 4 publications

(17 citation statements)

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“… 2014 ; Saminathan et al. 2018 , 2019 ). Although, more than 40 years ago, induction of IFN-Is by BTV infection was reported, the mechanism of IFN-Is induction has remained unknown for several years.…”

Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%

“… 2014 ; Saminathan et al. 2018 , 2019 ). The IFN-α/β was detected in the serum of sheep at 2 and 6 dpi inoculated with BTV-8.…”

Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%

“… 2012 ; Saminathan et al. 2018 , 2020 ). Conventional RT-PCR is advantageous over serological methods to identify the different serotypes of BTV within a single isolate containing ‘mixed’ serotypes (Prasad et al.…”

Section: Laboratory Diagnosis Of Btmentioning

confidence: 99%

“… 2011 ; Saminathan et al. 2018 ). Studies have reported that intradermal route of inoculation of BTV-23 is more potent in reproducing many aspects of natural infection such as prominent clinical pathology (pyrexia from 3 to 8 dpi, coronitis and lameness) and viral immune responses (including viremia, dissemination and localization to different organs) when compared to intravenous route (prolonged pyrexia was absent) of inoculation (Hemati et al.…”

Section: Pathology Of Btv Infectionmentioning

confidence: 99%

“…1991 ; Saminathan et al. 2018 ). Genetically IFN-α/β gene knockout mice (Calvo-Pinilla, Rodriguez-Calvo, Anguita, et al.…”

Section: Introductionmentioning

confidence: 99%

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An updated review on bluetongue virus: epidemiology, pathobiology, and advances in diagnosis and control with special reference to India

Saminathan

Singh

Khorajiya

et al. 2020

Veterinary Quarterly

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Bluetongue (BT) is an economically important, non-contagious viral disease of domestic and wild ruminants. BT is caused by BT virus (BTV) and it belongs to the genus Orbivirus and family Reoviridae. BTV is transmitted by Culicoides midges and causes clinical disease in sheep, white-tailed deer, pronghorn antelope, bighorn sheep, and subclinical manifestation in cattle, goats and camelids. BT is a World Organization for Animal Health (OIE) listed multispecies disease and causes great socio-economic losses. To date, 28 serotypes of BTV have been reported worldwide and 23 serotypes have been reported from India. Transplacental transmission (TPT) and fetal abnormalities in ruminants had been reported with cell culture adopted live-attenuated vaccine strains of BTV. However, emergence of BTV-8 in Europe during 2006, confirmed TPT of wild-type/field strains of BTV. Diagnosis of BT is more important for control of disease and to ensure BTV-free trade of animals and their products. Reverse transcription polymerase chain reaction, agar gel immunodiffusion assay and competitive enzyme-linked immunosorbent assay are found to be sensitive and OIE recommended tests for diagnosis of BTV for international trade. Control measures include mass vaccination (most effective method), serological and entomological surveillance, forming restriction zones and sentinel programs. Major hindrances with control of BT in India are the presence of multiple BTV serotypes, high density of ruminant and vector populations. A pentavalent inactivated, adjuvanted vaccine is administered currently in India to control BT. Recombinant vaccines with DIVA strategies are urgently needed to combat this disease. This review is the first to summarise the seroprevalence of BTV in India for 40 years, economic impact and pathobiology.

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Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%

“… 2014 ; Saminathan et al. 2018 , 2019 ). The IFN-α/β was detected in the serum of sheep at 2 and 6 dpi inoculated with BTV-8.…”

Section: Immunopathology Of Btv Infectionmentioning

confidence: 99%