Factors affecting the quality of life of patients with idiopathic Parkinson's disease-a cross-sectional study in an outpatient clinic attendees

Sławek, Jarosław; Derejko, Mirosława; Lass, Piotr

doi:10.1016/j.parkreldis.2005.04.006

Cited by 119 publications

(115 citation statements)

References 25 publications

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“…The close relationship among these factors is well known in depression with PD. 24,25,[27][28][29][30][31]38,40 It was to be found that the duration of PD symptoms was not related to depression, which supports the idea that depression might be a neuropathological process occurring concomitantly or before the degeneration of motor systems, which is similar with other study. 41 An interesting and surprising finding was that H-Y stage and disability was not associated with depression in multivariate logistic regression model but was significant in univariate analysis.…”

Section: Discussionsupporting

confidence: 80%

“…21,22,38,40,41 It is likely that depression in PD is multifactorial which includes age, sex, disease severity, longer disease duration, a younger PD onset age, frequent fall, lower education level, smoking and regular use of non-aspirin bases NSAIDs or analgesics. [23][24][25][26][27][28][29][30][31] Whereas a recent study reported that PD patients with depression were associated with different demographic and clinical factors. [38][39][40][41] These findings emphasize the need to study the factors associated with depression in this population.…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Khalil¹,

Rahman²,

Munira

et al. 2018

Bangladesh Med Res Counc Bull

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Depression in idiopathic Parkinson's disease is highly prevalent that can significantly impair the quality of life. Its exact mechanism of development is still poorly understood. It is well studied in western population but data from Asia especially in the South Asian region is limited. Considering this, to identify the potential risk factors of depression, a cross-sectional study was conducted among Parkinson's disease patients attending a tertiary care hospital in Bangladesh between July 2013-June 2014, in the Department of Neurology, Shaheed Suhrawardy Medical College and Hospital in Dhaka, Bangladesh. One hundred thirty seven cases of Parkinson's disease were enrolled, based on UK Parkinson's Disease Society Brain Bank criteria. Brain MRI was done in all cases, and patients with aphasia, significant cognitive deficits, secondary Parkinsonism were excluded. The overall prevalence of depression in the study population was 42%. There were no significant differences in gender, residence, education, smoking and marital status. In univariate analysis, age≥70 years, un-employed, right side predominantly involved, disease duration ≥5 years, sleep disturbance, postural instability, dose of levodopa ≥500 mg/day, Hoehn and Yahr stage ≥III and moderate to severe disability were significantly associated with depressive disorder. Whereas in multivariate linear stepwise regression model, age ≥70 years, (p=0.044), right side predominant involvement (p<0.001); sleep disturbance (p=0.006) and dose of levodopa ≥500 mg/day (p<0.001) were the major risk factors for depressive disorder. A significant proportion of Parkinson's disease patients suffer from depression. It was identified that depression in Parkinson's disease was significantly associated with advancing age, predominate right side involvement, sleep disturbance and higher daily dose of levodopa.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Risk Factors of Major Depressive Disorder in Parkinson’s Disease

Khalil¹,

Rahman²,

Munira

et al. 2018

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

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“…this study showed that disease severity, when assessed by Hohen and Yahr stages, harmfully affects QoL in activities involving motor skills 19 , as seen in table 1. the higher the disease stage, the worse the quality of life in aspects concerning physical independence 20,21 . studying the dimensions of emotional and cognitive aspects, it was observed that the results were not as expected.…”

Section: Discussionmentioning

confidence: 62%

“…this may be explained by the patients' initial reaction acknowledging they have an incurable, progressive disease and may become physically, emotionally and economically dependent, thus causing emotional problems. It is known that PD-associated depression sometimes precedes motor disabilities 19,22 .…”

Section: Discussionmentioning

confidence: 99%

Quality of life scale in parkinson's disease PDQ-39 - (Brazilian Portuguese version) to assess patients with and without levodopa motor fluctuation

Souza

Borges

Silva

et al. 2007

Arq. Neuro-Psiquiatr.

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-Quality of life (QoL) is an important treatment outcome indicator in Parkinson's disease (PD). the aim of this study is to assess the usefulness of the Parkinson's disease questionnaire -PDQ-39 (Brazilian Portuguese Version) in measuring QoL of PD patients with or without motor fluctuations. Fifty-six PD patients with mean disease duration of 7.4 years were assessed and 41 of them (73.3%) had motor fluctuations. the PDQ-39 has eight dimensions ranging from 0 to 100; being the higher the score, the worse the QoL. comparing groups with and without motor fluctuations showed that the dimensions mobility, activities of daily living (ADL), communication and bodily discomfort scored higher in the fluctuating group. there was a tendency to see that the higher the Hoehn and Yahr (HY) scale stages, the higher the PDQ-39 scores. Patients suffering from the disease for more than five years had worse PDQ-39 scores only in the items ADL and communication, when compared with those with the disease for ≤ 5 years. the PDQ-39 is an instrument that detects decrease in QoL of PD patients and the presence of motor fluctuations predicts QoL reduction.KeY worDs: Parkinson's disease, quality of life, psychomotor performance, levodopa Escala para qualidade de vida na doença de Parkinson -PDQ 39 (versão do Português falado no Brasil) como instrumento para avaliação de pacientes com e sem flutuação motora decorrente da levodopa resumo -A qualidade de vida (QdV) é um item importante para se mensurar o sucesso do tratamento na doença de Parkinson (DP). o objetivo deste estudo foi o de avaliar a utilidade do questionário sobre a doença de Parkinson -PDQ-39 (versão em língua portuguesa falada no Brasil) para mensurar a QdV dos pacientes parkinsonianos com e sem flutuação motora. Nós avaliamos 56 pacientes com DP com tempo médio da doença de 7,4 anos, e destes 41 (73,3%) apresentavam flutuação motora. A PDQ-39 tem oito domínios que variam de 0 a 100 e quanto maior o escore pior a QdV. A comparação dos grupos de pacientes com e sem flutuação motora mostrou que os domínios: mobilidade, atividades de vida diária, comunicação e desconforto corporal tinham escores maiores nos flutuadores. Quanto maiores os estágios de Hoehn e Yahr (HY) da doença, maiores os escores da PDQ-39. Pacientes com mais de 5 anos de evolução da doença mostraram escores piores da PDQ39 apenas nos itens atividades da vida diária e comunicação se comparados a pacientes com 5 anos ou menos de doença. A PDQ-39 é um instrumento capaz de detectar declínio da QdV de pacientes com DP e a presença de flutuação motora é um preditor para redução na QdV. Parkinson's disease (PD) ranks second in prevalence of degenerative disease of the nervous system, after Alzheimer's disease, and it is estimated that 0.3% of population is affected 1 . A recent Brazilian study carried out in the town of Bambuí, state of minas Gerais, Brazil, showed that PD affects 3.3% of individuals aged over 65 years 2 . especially in its initial stages, PD symptoms are mainly motor, later on cognitive dysf...

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“…Therefore, the assessment of quality of life is subjective and multidimensional 2 , and it varies according to the progression of the disease 5 . The assessment of the impact of the illness on quality of life is an important measure of treatment efficacy 6 because the most common clinical scales do not appropriately assess the nonmotor symptoms related to the disease. One of these scales is the Parkinson's Disease Questionnaire (PDQ-39) is a specific instrument for PD, and has been shown to be viable, valid, consistent, reliable, responsive and reproducible [7][8][9] in the assessment of the functional, emotional and psychosocial aspects of the patient's quality of life.…”

Section: Introductionmentioning

confidence: 99%