Factors associated with Coxiella burnetii antibody positivity in Danish dairy cows

Paul, Suman; Agger, Jens Frederik; Markussen, Bo; Christoffersen, Anna-Bodil; Agerholm, Jørgen Steen

doi:10.1016/j.prevetmed.2012.05.015

Cited by 43 publications

(63 citation statements)

References 30 publications

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“…However, it was well below the range of 12.78 to 29.9% reported in the cattle from northern parts of country by other workers (Joshi et al, 1978;Vaidya et al, 2010), which may be attributed to the investigation of animals at household level, with not more than 3 cattle per house examined in the present study. On contrary, studies involving large cattle herd size with intensive farming practices were found to have a positive association with C. burnetii infection (McCaughey et al, 2010;Ryan et al, 2011;Paul et al, 2012;Agger & Paul, 2014;Boroduske et al, 2017). The positivity of a serum sample in both trans-PCR and ELISA points to an active cycling of the pathogen within the herd/animal, where the animals get infected and seroconverts frequently as described by other researchers (Freick et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Seroscreening of lactating cattle for coxiellosis by TRANS-PCR and commercial ELISA in Kerala, India

Dhaka¹,

Malik²,

Yadav³

et al. 2017

JEBAS

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Section: Discussionmentioning

confidence: 99%

Seroscreening of lactating cattle for coxiellosis by TRANS-PCR and commercial ELISA in Kerala, India

Dhaka¹,

Malik²,

Yadav³

et al. 2017

JEBAS

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“…All samples were tested in duplicates (twice) and the optical densities (OD) of the samples were averaged and corrected by subtracting the OD of the negative control. Serum based tests were performed using the commercial CHEKIT Q-Fever Antibody ELISA Test Kit (IDEXX, Liebefeld-Bern, Switzerland) based on C. burnetii inactivated phase 1 and phase 2 antigens (Paul et al, 2012). The positive cut-off value (S/P ratio) of iELISA individual animal sera was ≥ 40%.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Coxiella Burnetii Infection in Cattle, Black Bengal Goats and Ticks in Bangladesh

Chakrabartty¹,

Bhattacharjee²,

Sarker³

et al. 2016

Bangl. J. Vet. Med.

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The objectives of this study were to determine the prevalence of Coxiella burnetii infection in domestic ruminants and to detect Coxiella burnetii DNA from ticks and serum samples. A total of 24 ticks, 91 goats and 81 cattle serum samples with the history of abortion and reproductive disorders were collected from the different areas in Bangladesh. The serum samples were tested by CHEKIT Q-Fever Antibody ELISA Test Kit and Coxiella burnetii DNA was detected by multiplex quantitative realtime PCR. The overall prevalence was 7.6% and 6.1% in goats and cattle, respectively. However, none of seropositive samples and tick samples was positive in quantitative real-time PCR.Keywords: Q fever, Coxiella burnetii, Black Bengal goat, cattle, tick, Bangladesh INTRODUCTIONQ fever is a widespread zoonosis that is caused by Coxiella burnetii, an obligate, Gram-negative, intracellular bacterium (Baca and Pratesky, 1983;Behymer and Riemann, 1989;Kazar, 2005). This disease, described for the first time among abattoir workers in 1937 in Queensland, Australia, is now recognized as being endemic worldwide (Derrick, 1983;Maurin and Raoult, 1999). Both public and animal health issues are closely related to Q fever. The reservoir includes mammals, birds and arthropods mainly ticks (Ioannou et al., 2009). Domestic ruminants are often asymptomatic carriers of C. burnetii and are considered the most important reservoir and source for human Q fever (Woldehiwet, 2004). Coxiella burnetii is present in clinically inconspicuous sheep flocks ( Angela et al., 2012). However, other animal species like birds, reptiles, arthropods or pets can also be infected and possibly transmit the disease to humans (Angelakis and Raoult, 2009). In humans, Q fever can lead to an acute disease (self-limited febrile illness, pneumonia, or hepatitis) or to a chronic disease, mainly endocarditis in immunocompromised patients or patients suffering from valvulopathy and abortions and stillbirth in pregnant women (Angelakis and Raoult, 2009). Q fever or coxiellosis occurs during late pregnancy (about 15 days before term) and in animals provide abortions and stillbirths in goats and sheep, infertility, mastitis and endometritis in cattle (Heinzen et al., 1999;Woldehiwet, 2004;Berri et al., 2005) with associated economic impact for the herd.To control the spread of C. burnetii from animals to humans, the detection of shedders of C. burnetii and the knowledge of the prevalence of the infection are imperative. Only few reports on the prevalence of Q fever in animals are available in Bangladesh on the prevalence of Q fever in domestic ruminants were found from literature search in Bangladesh (Haider et al., 2015;Rahman et al., 2016). Haider et al. (2015) reported seroprevalence of Q fever in cattle and goats that were brought to veterinary hospitals in Netrokona, Dinajpur, and Chittagong districts in Bangladesh. Rahman et al. (2016) reported herd-level prevalence of Q fever in dairy cattle investigating bulk milk (Satkhira, Rajshahi, Chittagong), animal-level seropre...

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“…In contrast, several studies have identified parity (McCaughey et al, 2010;Böttcher et al, 2011;Paul et al, 2012;Tutusaus et al, 2013), C. burnetii shedding (Guatteo et al, 2007;Courcoul et al, 2010) and vaccination against the bacterium as maternal factors related to the C. burnetii seropositivity of their offspring. The lack of effects of these factors observed here may be explained by our small sample size.…”

Section: Discussionmentioning

confidence: 93%

“…Some authors have linked the presence of anti-C. burnetii antibodies to placenta retention, abortion or infertility (Krauss et al, 1987;To et al, 1995To et al, , 1998Hässig and Lubsen, 1998). Others have noted no negative impacts of C. burnetii seropositivity in dairy cattle (Lange et al, 1992;Nielsen et al, 2011;Paul et al, 2012;Muskens et al, 2012), while some even argue that seropositivity improves fertility and helps maintain pregnancy in dairy cattle .…”

mentioning

confidence: 99%

“…Several studies have shown that C. burnetii seropositivity increases with parity (McCaughey et al, 2010;Böttcher et al, 2011;Paul et al, 2012;Tutusaus et al, 2013) and antibody levels remain stable for long periods (Guatteo et al, 2007;Garcia-Ispierto et al, 2011;Nogareda et al, 2012). However, most likely because of the difficulty in detecting infection at the farm level , the pathogenesis of the disease is poorly understood.…”

mentioning

confidence: 99%

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Coxiella burnetii antibody dynamics in heifers born to vaccinated versus non-vaccinated dams in a chronically infected dairy herd

Tutusaus

García-Ispierto

López‐Gatius

2015

Acta Veterinaria Hungarica

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This study was designed to compare Coxiella burnetii antibody dynamics in heifers born to vaccinated or non-vaccinated dams in a single high-producing dairy herd chronically infected with the bacterium. Antibody dynamics were examined from birth to the postpartum period in replacement heifers (n = 14) born to non-vaccinated dams (n = 7) or to dams that had been vaccinated on gestation days 171-177 (n = 7) and 192-198. Samples of blood, milk, faeces, vaginal fluid, colostrum and cotyledons (the latter two only at parturition) were obtained in the dams over the period from gestation days 171-177 to postpartum days 91-97. Blood samples were used to detect antibodies against C. burnetii and remaining samples for PCR identification of the bacterium. In their calves/heifers, blood samples for antibody determinations were collected from birth to postpartum at the time points 1-7 and 22-28 days and 3, 6 and 12 months of age; 90-96 and 210-216 days of gestation; and 22-28 days postpartum. All calves were born seronegative for C. burnetii. Irrespective of the shedding status of their mothers (7 were C. burnetii shedders), seroconversion occurred after colostrum intake in all calves born to seropositive cows (n = 9) and in two of three vaccinated seronegative dams. Thereafter antibody titres gradually declined and by 6 months of age all calves were seronegative. Seronegativity persisted until their first postpartum period. These findings indicate that cows vaccinated during advanced pregnancy transfer immunity to their calves via the colostrum. Maternal C. burnetii antibodies in calves persisted for three months in calves born both to seronegative vaccinated and seropositive dams.

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Factors associated with Coxiella burnetii antibody positivity in Danish dairy cows

Cited by 43 publications

References 30 publications

Seroscreening of lactating cattle for coxiellosis by TRANS-PCR and commercial ELISA in Kerala, India

Seroscreening of lactating cattle for coxiellosis by TRANS-PCR and commercial ELISA in Kerala, India

Prevalence of Coxiella Burnetii Infection in Cattle, Black Bengal Goats and Ticks in Bangladesh

Coxiella burnetii antibody dynamics in heifers born to vaccinated versus non-vaccinated dams in a chronically infected dairy herd

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