Factors associated with early and late failure of dental implants

Sakka, Salah; Baroudi, Kusai; Nassani, Mohammad Zakaria

doi:10.1111/j.2041-1626.2012.00162.x

Cited by 235 publications

(187 citation statements)

References 16 publications

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“…According to mechanostat theory by Frost [14], both bone growth and resorption are closely dependent on affecting mechanical forces. So the osseointegrated implant can be overloaded and not survive due to loading [15]. However, there are no clear guidelines: how much functional and para-functional loading can be injurious for dental implant, what mechanical factors can decrease load effect for such kind of restorations and what should be avoided.…”

Section: Introductionmentioning

confidence: 99%

The Prosthetic Influence and Biomechanics on Peri-Implant Strain: a Systematic Literature Review of Finite Element Studies

Maminskas¹,

Puišys²,

Kuoppala³

et al. 2016

JOMR

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ObjectivesTo systematically review risks of mechanical impact on peri-implant strain and prosthetic influence on stability across finite element studies.Material and MethodsAn online literature search was performed on MEDLINE and EMBASE databases published between 2011 and 2016. Following keywords tiered screening and selection of the title, abstract and full-text were performed. Studies of finite element analysis (FEA) were considered for inclusion that were written in English and revealed stress concentrations or strain at peri-implant bone level.ResultsThere were included 20 FEA studies in total. Data were organized according to the following topics: bone layers, type of bone, osseointegration level, bone level, design of implant, diameter and length of implant, implant-abutment connection, type of supra-construction, loading axis, measurement units. The stress or strain at implant-bone contact was measured over all studies and numerical values estimated. Risks of overloading were accented as non-axial loading, misfits, cantilevers and the stability of peri-implant bone was related with the usage of platform switch connection of abutment.ConclusionsPeri-implant area could be affected by non-axial loading, cantilever prosthetic elements, crown/implant ratio, type of implant-abutment connection, misfits, properties of restoration materials and antagonistic tooth. The heterogeneity of finite element analysis studies limits systematization of data. Results of these studies are comparable with other findings of in vitro, in vivo, prospective and retrospective studies.

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Section: Introductionmentioning

confidence: 99%

The Prosthetic Influence and Biomechanics on Peri-Implant Strain: a Systematic Literature Review of Finite Element Studies

Maminskas¹,

Puišys²,

Kuoppala³

et al. 2016

JOMR

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show abstract

“…However, peri-implant infections (PIIs) still form a threat for a successful treatment. 1,2 PIIs are characterized by the inflammatory destruction of the implant-supporting tissues, as a result of biofilm formation on the surface of the implant. 3,4 Dental implants are at an increased risk of contamination because the oral cavity is a dynamic ecosystem continuously colonized by microorganisms.…”

Section: Introductionmentioning

confidence: 99%

In vitro studies of nanosilver-doped titanium implants for oral and maxillofacial surgery

Pokrowiecki¹,

Zaręba²,

Szaraniec³

et al. 2017

IJN

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The addition of an antibacterial agent to dental implants may provide the opportunity to decrease the percentage of implant failures due to peri-implantitis. For this purpose, in this study, the potential efficacy of nanosilver-doped titanium biomaterials was determined. Titanium disks were incorporated with silver nanoparticles over different time periods by Tollens reaction, which is considered to be an eco-friendly, cheap, and easy-to-perform method. The surface roughness, wettability, and silver release profile of each disc were measured. In addition, the antibacterial activity was also evaluated by using disk diffusion tests for bacteria frequently isolated from the peri-implant biofilm: Streptococcus mutans, Streptococcus mitis, Streptococcus oralis, Streptococcus sanguis, Porphyromonas gingivalis, Staphylococcus aureus , and Escherichia coli . Cytotoxicity was evaluated in vitro in a natural human osteoblasts cell culture. The addition of nanosilver significantly increased the surface roughness and decreased the wettability in a dose-dependent manner. These surfaces were significantly toxic to all the tested bacteria following a 48-hour exposure, regardless of silver doping duration. A concentration of 0.05 ppm was sufficient to inhibit Gram-positive and Gram-negative species, with the latter being significantly more susceptible to silver ions. However, after the exposure of human osteoblasts to 0.1 ppm of silver ions, a significant decrease in cell viability was observed by using ToxiLight™ BioAssay Kit after 72 hours. Data from the present study indicated that the incorporation of nanosilver may influence the surface properties that are important in the implant healing process. The presence of nanosilver on the titanium provides an antibacterial activity related to the bacteria involved in peri-implantitis. Finally, the potential toxicological considerations of nanosilver should further be investigated, as both the antibacterial and cytotoxic properties may be observed at similar concentration ranges.

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“…[3–9] The leading cause of failure for orthopaedic and dental implants is aseptic loosening of the implant from the surrounding bone tissue. [10–13] A common hypothesis for aseptic loosening is that poor osseointegration at early times allows for micromotions of the implant relative to the bone. [14–18] In the case of hips, knees, and teeth, these areas experience and transfer stresses during activities such as walking and chewing, which may lead to worsening of micromotions and ultimately result in the need for a revision surgery.…”

Section: Introductionmentioning

confidence: 99%

Engineered protein coatings to improve the osseointegration of dental and orthopaedic implants

et al. 2016

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Here we present the design of an engineered, elastin-like protein (ELP) that is chemically modified to enable stable coatings on the surfaces of titanium-based dental and orthopaedic implants by novel photocrosslinking and solution processing steps. The ELP includes an extended RGD sequence to confer bio-signaling and an elastin-like sequence for mechanical stability. ELP thin films were fabricated on cp-Ti and Ti6Al4V surfaces using scalable spin and dip coating processes with photoactive covalent crosslinking through a carbene insertion mechanism. The coatings withstood procedures mimicking dental screw and hip replacement stem implantations, a key metric for clinical translation. They promoted rapid adhesion of MG63 osteoblast-like cells, with over 80% adhesion after 24 hours, compared to 38% adhesion on uncoated Ti6Al4V. MG63 cells produced significantly more mineralization on ELP coatings compared to uncoated Ti6Al4V. Human bone marrow mesenchymal stem cells (hMSCs) had an earlier increase in alkaline phosphatase activity, indicating more rapid osteogenic differentiation and mineral deposition on adhesive ELP coatings. Rat tibia and femur in vivo studies demonstrated that cell-adhesive ELP-coated implants increased bone-implant contact area and interfacial strength after one week. These results suggest that ELP coatings withstand surgical implantation and promote rapid osseointegration, enabling earlier implant loading and potentially preventing micromotion that leads to aseptic loosening and premature implant failure.

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Factors associated with early and late failure of dental implants

Cited by 235 publications

References 16 publications

The Prosthetic Influence and Biomechanics on Peri-Implant Strain: a Systematic Literature Review of Finite Element Studies

The Prosthetic Influence and Biomechanics on Peri-Implant Strain: a Systematic Literature Review of Finite Element Studies

In vitro studies of nanosilver-doped titanium implants for oral and maxillofacial surgery

Engineered protein coatings to improve the osseointegration of dental and orthopaedic implants

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