Factors Associated With Fatigue in Sarcoidosis

Fleischer, Michael; Hinz, Andreas; Brähler, Elmar; Wirtz, Hubert; Bosse-Henck, A.

doi:10.4187/respcare.02080

Cited by 42 publications

(34 citation statements)

References 40 publications

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“…Fleisher et al in the German study [33] of over 1000 patients with sarcoidosis proved the influence of several different factors on the severity of fatigue. They reported, that patients with muscle, bone and neural involvement presented more severe fatigue than patients with pulmonary sarcoidosis.…”

Section: The Influence Of Treatment Comorbidities and Extrapulmonarymentioning

confidence: 99%

“…Other scales used for the multidimentional assessment of sarcoidosis-related fatigue include: WHOQOL-100 -World Health Organization Quality of Life Assessment Instrument-100 [12], MFI -Multidimentional Fatigue Inventory [16], FACIT-F -Functional Assessment of the Chronic Illness Therapy-Fatigue [17], SHQ -Sarcoidosis Health Questionnaire, SF-36 [18], CRDQ -Chronic Respiratory Disease Questionnaire [12]. BDIBeck Depression Inventory score [12] may be used for the assessment of accompanying depression, and may be helpful in differentiating fatigue from depression-related symptoms.…”

Section: Different Measures To Estimate Fatiguementioning

confidence: 99%

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Fatigue Syndrome in Sarcoidosis

Górski

Piotrowski

2016

Advances in Respiratory Medicine

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Sarcoidosis is an inflammatory disease of unknown etiology. Most commonly it results in the formation of non-caseating granulomas in intrathoracic lymph nodes and lung parenchyma, but the clinical course and picture may be complicated by extrapulmonary involvement and many non-respiratory signs and symptoms which are directly related to the disease. In addition, sarcoidosis patients may suffer from a plethora of symptoms of uncertain or unknown origin. Fatigue is one of these symptoms, and according to some authors it is reported by the majority of patients with active sarcoidosis, but also by a smaller proportion of patients with inactive sarcoidosis, or even with complete clinical and radiological remission. Therefore the term fatigue syndrome is frequently used to name this clinical problem. The definition of fatigue syndrome in sarcoidosis is imprecise and the syndrome is usually recognized by use of validated questionnaires. In this review the uptodate knowledge in this field was presented and different challenges connected with this syndrome were described.

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Section: The Influence Of Treatment Comorbidities and Extrapulmonarymentioning

confidence: 99%

Section: Different Measures To Estimate Fatiguementioning

confidence: 99%

Fatigue Syndrome in Sarcoidosis

Górski

Piotrowski

2016

Advances in Respiratory Medicine

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“…We assessed fatigue by the Multidimensional Fatigue Inventory (MFI-20) [22], a standardized questionnaire that has previously been validated in patients with sarcoidosis [23,24]. The MFI is a 20-item self-reported questionnaire that covers the following 5 subscales: general fatigue, physical fatigue, mental fatigue, reduced activity, and reduced motivation.…”

Section: Fatiguementioning

confidence: 99%

Physical Activity and Fatigue in Patients with Sarcoidosis

Bahmer

Watz

Develaska³

et al. 2017

Respiration

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Background:Little is known about physical activity in daily life among patients with sarcoidosis. Fatigue is a frequent and disabling symptom that might negatively affect physical activity levels. Methods: In patients with sarcoidosis, we measured physical activity (steps per day) by accelerometry (SenseWear Armband) for 1 week. We assessed lung function (DLCO, FVC), exercise capacity (6-min walking distance . Results: We investigated 57 patients with sarcoidosis (mean age 50 years, 56% male, mean DLCO 73% predicted, mean FVC 91% predicted, mean 6MWD 525 m, mean steps per day 7,490), of whom n = 14 (25%) had severe fatigue. The MFI-20 subscales "reduced activity" and "physical fatigue" were weakly associated with steps per day on a bivariate level (Spearman ρ = -0.274 and ρ = -0.277, respectively; p < 0.05), while the other subscales and the total score were not. 6MWD, SGRQ score, and SF-12 (physical health) score showed stronger associations with steps per day in bivariate analyses (Pearson r = 0.499, r = -0.386, and r = 0.467, respectively; p < 0.01), and were independent predictors of steps per day in multivariate linear regression analyses adjusting for confounders (p < 0.05). In ROC curve analyses, 6MWD, SGRQ score, and SF-12 (physical health) score properly identified sedentary patients (steps per day <5,000; AUROC 0.90, 0.81, and 0.80, respectively; p < 0.01). Fatigue was less predictive (MFI-20 subscale "general fatigue," AUROC 0.70; p = 0.03). Conclusion: While exercise capacity and quality of life measurements were robust predictors of physical activity in patients with sarcoidosis, associations of objectively measured physical activity with fatigue were surprisingly weak. In sarcoidosis, fatigue might not preclude affected patients from being physically active, although this symptom is subjectively perceived as highly disabling.

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“…135,136 It has been translated into over 20 different languages [137][138][139] and is the most commonly used instrument for assessing fatigue in sarcoidosis. 34,35,44,45,50,67,79,81,83,84,88,[134][135][136]138,[140][141][142][143][144][145][146][147][148][149][150][151][152][153][154][155][156] Five questions address mental fatigue, and the other five address physical fatigue. Each question is rated on a five-point scale for a total score of 10 to 50 points (higher scores indicate worse fatigue).…”

Section: Fatigue Assessment Scalementioning

confidence: 99%

Health-Related Quality of Life in Sarcoidosis

Ndili

2020

Semin Respir Crit Care Med

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Health-related quality of life (HRQoL) describes an individual's perception of the impact of health, disease, and treatment on their quality of life (QoL). It is a reflection of how the manifestation of an illness and its treatment is personally experienced. Assessing HRQoL is particularly important in sarcoidosis because the attributable disease mortality is relatively low, and one of the major reasons for initiating treatment is to improve quality of life. HRQoL has been assessed in sarcoidosis using various generic and sarcoid-specific patient-reported outcome measures (PROMs). It is important that both the direct and indirect effects of the disease, as well as potential toxicities of therapy, are captured in the various PROMs used to assess HRQoL in sarcoidosis. This article provides a general overview of HRQoL in patients with sarcoidosis. It describes the various PROMs used to assess HRQoL in sarcoidosis and addresses the various factors that influence HRQoL in sarcoidosis. Specific attention is paid to fatigue, small fiber neuropathy, corticosteroid therapy, and other disease-specific factors that affect HRQoL in sarcoidosis. It also provides an insight into interventions that have been associated with improved HRQoL in sarcoidosis and offers suggestions for future research in this important area.

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Factors Associated With Fatigue in Sarcoidosis

Cited by 42 publications

References 40 publications

Fatigue Syndrome in Sarcoidosis

Fatigue Syndrome in Sarcoidosis

Physical Activity and Fatigue in Patients with Sarcoidosis

Health-Related Quality of Life in Sarcoidosis

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