Factors associated with in-hospital mortality in patients after acute cerebrovascular accident (according to the REGION-M register)

Загребельный, А. В.; Лукина, Ю. В.; Кутишенко, Н. П.; Лукьянов, М. М.; Дмитриева, Н. А.; Воронина, В. П.; Окшина, Е. Ю.; Лерман, О. В.; Благодатских, С. В.; Никошнова, Е. С.; Будаева, И. В.; Бойцов, С. А.; Драпкина, О. М.; Марцевич, С. Ю.

doi:10.15829/1728-8800-2020-1-2443

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Например, при анализе историй болезни больных острым инсультом в регистре РЕГИОН-М (РЕГИстр больных, перенесших Острое Нарушение мозгового кровообращения, Москва) у некоторых больных в диагнозе не упоминался сахарный диабет, а в назначениях, в т.ч. и при выписке из стационара, присутствовали сахароснижающие препараты [12,13]. Понятно, что алгоритм установки реального диагноза в таких случаях должен быть единым.…”

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Observational studies and registers. Their quality and role in modern evidence-based medicine

Марцевич¹,

Кутишенко²,

Лукина³

et al. 2021

Cardiovasc Ther Prev

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The article describes the basic rules for conducting observational studies, in particular, registers. The principles of the assessment of its quality and impact on the results are discussed. The potential for evaluating therapeutic effect and side effects in randomized controlled trials (RCTs) and observational studies is compared. Effects of one drug identified in RCTs and observational studies are compared.

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Observational studies and registers. Their quality and role in modern evidence-based medicine

Марцевич¹,

Кутишенко²,

Лукина³

et al. 2021

Cardiovasc Ther Prev

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Long-term survival of patients with cerebrovascular accident in different age groups in the REGION-M registry

Толпыгина¹,

Zagrebelnyy²,

Чернышева

et al. 2023

Russ J Cardiol

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Aim. To study the two-year survival rate of patients with cerebrovascular accident (CVA) in different age groups.Material and methods. The outpatient part of the REGION-M registry included 684 patients assigned to the City Polyclinic № 64 in Moscow, discharged from the F. I. Inozemtsev City Clinical Hospital (Moscow) in the period from January 1, 2012 to April 30, 2017 with a confirmed diagnosis of stroke or transient ischemic attack. All patients were divided into 5 age groups: group 1 — from 18 to 50 years old (n=72 (10,5%)), group 2 — from 51 to 60 years old (n=122 (17,8%)), group 3 — from 61 to 70 years old (n=156 (22,8%)), group 4 — from 71 to 80 years old (n=185 (27,0%)) and group 5 — 81 years and above (n=149 (21,8%)). Patient survival was assessed after 2 years of follow-up.Results. The mortality rate of patients during the follow-up period significantly increased with age as follows: in patients of 18-50 years old — 4%, 51-60 years old — 9,8%, 61-70 years old — 23,7%, 71-80 years old — 34%, 81-100 years old — 55% (p<0,0001). The relative death risk was 2,3 in group 2 (NA), 6,8 in group 3 (p<0,001), 9,8 in group 4 (p<0,0001) and 18,5 in group 5 (p<0,0001) compared with group 1. With increasing age in the study cohort, the proportion of women increased as follows: from 47,2% in group 1 to 77,9% in group 5 (p<0,0001). However, mortality among men and women in the groups did not differ. Patients in older age groups were more likely to have comorbidities and disability before the CVA. With increasing age, ischemic stroke was significantly more common and transient ischemic attack was less common (p<0,001).Conclusion. Mortality of patients who underwent stroke was significantly higher in older age groups and did not differ among men and women.

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Long-term survival of patients with cerebrovascular accident, depending on sex and age: data from the REGION-M registry

Tolpygina,

Zagrebelny,

Chernysheva

et al. 2023

Cardiovasc Ther Prev

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Aim. To study the long-term survival of patients with cerebrovascular accident, depending on sex and age.Material and methods. The outpatient part of the REGION-M registry (patients with cerebrovascular accident, hospitalized in a Moscow hospital) included 684 patients assigned to the City Polyclinic № 64 (Moscow), discharged from the F. I. Inozemtsev City Clinical Hospital (Moscow) in the period from January 1, 2012 to April 30, 2017 with a diagnosis of stroke, which were divided into 5 age groups: group 1 — ≤50 years, n=72 (10,5%), group 2 — 51-60 years old, n=122 (17,8%), group 3 — 61-70 years old, n=156 (22,8%), group 4 — 71-80 years old, n=185 (27,0%) and group 5 — ≥81 years old, n=149 (21,8%). The survival of patients was assessed at the 2nd and 3rd stages after 4,2 (2,4-5,6) and 5,5 (2,4-7,0) years.Results. The mortality of patients in the long-term follow-up period significantly increased with age. There were following mortality rate for stages 2 and 3 stages: 18-50 years old — 8,3 and 22,2%, 51-60 years old — 18 and 36,9%, 61-70 years old — 41 and 56,4%, 71-80 years old — 54,1 and 73%, >81 years — 76,5 and 87,9% (p<0,0001 for all groups). At stages 2 and 3, mortality among men was higher than among women in groups 2-4, below in group 1 and did not differ in the oldest age group. In multivariate analysis, the following factors had prognostic significance: age — hazard ratio (HR) of death, 1,035 (95% confidence interval (CI): 1,029-1,041, p=0,001), sex — HR, 0,720 (95% CI: 0,43-0,123, p=0,001) and disability before stroke — HR, 0,999 (95% CI: 0,998-1,000, p=0,002).Conclusion. In long-term follow-up, the mortality of patients with cerebrovascular accident was significantly higher in older age groups, as well as among men.

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Factors associated with in-hospital mortality in patients after acute cerebrovascular accident (according to the REGION-M register)

Cited by 4 publications

References 15 publications

Observational studies and registers. Their quality and role in modern evidence-based medicine

Observational studies and registers. Their quality and role in modern evidence-based medicine

Long-term survival of patients with cerebrovascular accident in different age groups in the REGION-M registry

Long-term survival of patients with cerebrovascular accident, depending on sex and age: data from the REGION-M registry

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