Factors associated with increased breast cancer-related lymphedema volume

Vignes, S.; Arrault, M.; Dupuy, Alain

doi:10.1080/02841860701403020

Cited by 83 publications

(59 citation statements)

References 16 publications

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“…Two recent studies complemented our study by reporting significantly less severe lymphedema among patients with BCT than with RM, all referred for treatment of lymphedema [17,18]. A non-comparative study reported a prevalence of 11% lymphedema in a BCT group with a treatment program similar to ours [19].…”

Section: Discussionmentioning

confidence: 41%

Arm and shoulder morbidity in breast cancer patients after breast-conserving therapy versus mastectomy

Nesvold

Dahl

Løkkevik³

et al. 2008

Acta Oncologica

149

108

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Section: Discussionmentioning

confidence: 41%

Arm and shoulder morbidity in breast cancer patients after breast-conserving therapy versus mastectomy

Nesvold

Dahl

Løkkevik³

et al. 2008

Acta Oncologica

149

108

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“…This method demonstrated excellent inter-and intra-observer reproducibility in comparison to water displacement which is considered the gold standard. [7][8][9] Participants, whose volume difference between the two arms was ‡5%, were considered as lymphedema-positive patients. Patients who had 5%-10%, 10%--20%, and ‡20% volume differences between two arms were considered as mild, moderate, and severe lymphedema.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors of Breast Cancer-Related Lymphedema

Ugur

Arıcı

Yaprak

et al. 2013

Lymphatic Research and Biology

105

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Introduction: Secondary lymphedema is one of the major important long-term complications of breast cancer treatment. The aim of this study is to determine patient-and treatment-related risk factors of lymphedema in breast cancer patients. Patients and Methods: Patients, who had been operated on for primary breast cancer at Akdeniz University Hospital and followed regularly between August 1984 and December 2009 were included in the study. In order to evaluate the arm swelling objectively, measurements were performed with a flexible tape measure for both arms, and limb volume was calculated using a truncated cone volume formula. Participants, whose volume difference between the two arms was ‡5%, were considered as lymphedema-positive patients. The SPSS program (SPSS inc. Chicago, IL) was used for statistical analysis. Results: The mean age of 455 patients was 50.6 years and the median follow-up time was 53 months. Lymphedema was found in 124 (27%) patients. Most of the patients with a history of postoperative wound infection (52%) and lymphangitis (57%) had lymphedema ( p = 0.003 and p = 0.002, respectively). Addition of radiation therapy increased lymphedema risk 1.83 times ( p = 0.007). The mean duration of the axillary drainage and number of the removed lymph nodes were 7.8 days and 19, respectively. The rate of lymphedema in patients with early stage breast cancer was less than patients with advanced breast cancer (24% and 35.3%, respectively, p = 0.018). Most of the patients (92%) with lymphedema had a high body mass index (BMI ‡25 kg/m 2 ), and obesity was another important factor for lymphedema ( p < 0.001). Conclusions:The most important treatment and patient-related risk factors for breast cancer-related lymphedema were obesity ( ‡ 25 kg/m 2 ), axillary lymph node dissection, postoperative radiotherapy, wound infection, history of lymphangitis, and duration of axillary drainage. Elimination or prevention of these risk factors may reduce the incidence of lymphedema.

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“…O risco para o aparecimento do linfedema está associado à dissecção e radioterapia axilar, obesidade, extensão da técnica cirúr-gica, infecção 5,9 , idade, número de linfonodos dissecados, número de linfonodos positivos e nível de retirada dos linfonodos 10 .…”

Section: Introductionunclassified

Avaliação das compensações linfáticas no pós-operatório de câncer de mama com dissecção axilar através da linfocintilografia

Rezende¹,

Pedras²,

Ramos³

et al. 2008

J. vasc. bras.

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ResumoO sistema linfático é um componente do corpo humano intimamente relacionado ao sistema venoso. Entretanto, o conhecimento científico a seu respeito é limitado. A etiologia e os fatores de risco para o desenvolvimento do linfedema no pós-operatório de câncer de mama são multifatoriais e ainda não foram completamente esclarecidos. O objetivo desta revisão da literatura foi descrever o padrão linfocintilográfico e avaliar as compensações linfáticas do membro superior no pós-operatório de câncer de mama com dissecção axilar. Palavras-chave:Sistema linfático, drenagem linfática, dissecção axilar, linfocintilografia, câncer de mama. AbstractThe lymphatic system is a component of the human body that is closely related to the venous system. However, scientific knowledge of this system is limited. The etiology and risk factors for the development of postoperative lymphedema in patients with breast cancer seem to be multifactorial and have not been fully understood yet. The objective of this review of the literature was to describe lymphoscintigraphic pattern and to evaluate upper limb lymphatic compensation following breast cancer surgery with axillary dissection.Keywords: Lymphatic system, lymphatic drainage, axillary dissection, lymphoscintigraphy, breast cancer. IntroduçãoO câncer de mama apresenta grandes e significativos índices de mortalidade entre as mulheres, sendo o segundo tipo de câncer mais freqüente no mundo e o mais comum entre a população feminina. No Brasil, para o ano de 2008, são esperados 49.400 novos casos, com uma taxa bruta estimada de 51 casos para cada 100.000 mulheres 1 .De acordo com a American Cancer Society, existem hoje nos Estados Unidos entre 1 e 2 milhões de sobreviventes ao câncer de mama, e cerca de 15 a 20% delas convivem diariamente com algum desconforto ou incapacidade em seus membros superiores. Estima-se que entre 120.000 e 600.000 pacientes sofram de alguma complicação pós-operatória 2 .O linfedema de membro superior ipsilateral à mama operada, complicação com tempo de instalação variá-vel entre 2 e 92 meses, com média de 14 meses 3,4 , apresenta incidência entre 24 e 49% após mastectomia, entre 4 e 28% após tumorectomia com dissecção axilar 5 e 34% após cirurgia combinada à radioterapia 6 , promovendo um substancial prejuízo funcional e psicológico para a paciente.O linfedema é a complicação pós-operatória mais comum, e seus efeitos adversos afetam diretamente a qualidade de vida das pacientes. Embora sua incidência esteja diminuindo devido ao diagnóstico precoce e ao

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Factors associated with increased breast cancer-related lymphedema volume

Abstract: Early diagnosis and management of lymphedema, weight control and advices to avoid cellulitis are the main controllable parameters in women to prevent severity of breast cancer-related lymphedema.

Cited by 83 publications

References 16 publications

Arm and shoulder morbidity in breast cancer patients after breast-conserving therapy versus mastectomy

Arm and shoulder morbidity in breast cancer patients after breast-conserving therapy versus mastectomy

Risk Factors of Breast Cancer-Related Lymphedema

Avaliação das compensações linfáticas no pós-operatório de câncer de mama com dissecção axilar através da linfocintilografia

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