Factors associated with low immunity to rubella infection on antenatal screening

Sathanandan, Deshanie; Gupta, Leena; Liu, Bette; Rutherford, Alison; Lane, J. G.

doi:10.1111/j.1479-828x.2005.00467.x

Cited by 24 publications

(25 citation statements)

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“…However, it is difficult to compare prevalences obtained in different seroprevalence studies due to differences in sampling methods, populations studied and serological tests used. The prevalence of protective antirubella IgG titres found in this study in pregnant women (95 %) was similar to the prevalence found in pregnant women in the United States of America (98 %) [37], Colombia (93 %) [33], Brazil (92 %) [34], Iran (96 %) [30], Turkey (94-100 %) [36,39] and Australia (93 %) [31], while it was higher than the prevalence found in Taiwan (89 %) [40], Germany (87 %) [41], Sudan (72 %) [42] and Poland (89 %) [35]. The prevalence of protective anti-measles titres found in this study in pregnant women (89 %) was similar to the prevalence found in pregnant women or neonates in the United States of America (88 %) [37], Argentina (87 %) [28], Japan (80-90 %) [29] and China (90 %) [43], while it was higher than the prevalence found in Germany (79 %) [41] and Iran (82 %) [30].…”

Section: Discussionsupporting

confidence: 89%

“…On the other hand, the study showed a null correlation between anti-rubella IgG titres and maternal age. Seroprevalence studies carried out in other countries found positive correlations between the anti-measles IgG titres in neonates/pregnant women and maternal age [14,[28][29][30], and positive [28], negative [31][32][33][34][35] or null [36,37] correlations between the anti-rubella IgG titres in neonates/ pregnant women and maternal age. The present study found the prevalence of protective antirubella IgG titres to be similar in the neonates of autochthonous and immigrant women (96.9 vs. 95.2 %).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of anti-rubella, anti-measles and anti-mumps IgG antibodies in neonates and pregnant women in Catalonia (Spain) in 2013: susceptibility to measles increased from 2003 to 2013

Plans

Ory

Campins

et al. 2015

Eur J Clin Microbiol Infect Dis

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Non-immune neonates and non-immune pregnant women are at risk of developing rubella, measles and mumps infections, including congenital rubella syndrome. We describe the seroepidemiology of measles, mumps and rubella (MMR) in neonates and pregnant women in Catalonia (Spain). Anti-rubella, anti-measles and anti-mumps serum IgG titres were assessed using enzyme-linked immunosorbent assay (ELISA) tests in 353 cord blood samples from neonates of a representative sample of pregnant women obtained in 2013. The prevalence of protective antibody titres in neonates was 96 % for rubella IgG (≥8 IU/ml), 90 % for measles IgG (>300 IU/ml) and 84 % for mumps IgG (>460 EU/ml). Slightly lower prevalences of protective IgG titres, as estimated from the cord blood titres, were found in pregnant women: 95 % for rubella IgG, 89 % for measles IgG and 81 % for mumps IgG. The anti-measles and anti-mumps IgG titres and the prevalences of protective IgG titres against measles and mumps increased significantly (p < 0.001) with maternal age. The prevalence of protective anti-measles IgG titres decreased by 7 % [odds ratio (OR) = 0.15, p < 0.001), the prevalence of protective anti-rubella IgG titres increased by 3 % (OR = 1.80, p < 0.05) and the MMR vaccination coverage (during childhood) in pregnant women increased by 54 % (OR = 2.09, p < 0.001) from 2003 to 2013. We recommend to develop an MMR prevention programme in women of childbearing age based on mass MMR vaccination or MMR screening and vaccination of susceptible women to increase immunity levels against MMR.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Prevalence of anti-rubella, anti-measles and anti-mumps IgG antibodies in neonates and pregnant women in Catalonia (Spain) in 2013: susceptibility to measles increased from 2003 to 2013

Plans

Ory

Campins

et al. 2015

Eur J Clin Microbiol Infect Dis

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“…17 Measurements of rubella antibodies during antenatal visits at the Royal London Hospital in 2000 showed that 9% of Asian immigrants were seronegative compared with 2% of whites. 18 Another study found that 10.0% of pregnant Asian immigrants in Catalonia, Spain, were susceptible to rubella, compared with 5.4% of pregnant women born indigenously.…”

Section: Discussionmentioning

confidence: 99%

Rubella Seroepidemiology and Catch-up Immunization among Pregnant Women in Taiwan: Comparison between Women Born in Taiwan and Immigrants from Six Countries in Asia

Lin¹,

Yang²,

Shih³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. Rubella vaccination in Taiwan started in 1986; mass vaccination was introduced into the national immunization program in 1992. In recent years, 17-31% of all marriages in Taiwan have been between Taiwanese men and foreign women. The aim of this study was to analyze rubella seroepidemiology and the rate of catch-up immunization in women. We recruited 10,089 pregnant women, including 1,920 immigrants, who had received prenatal examinations during 1999-2006. The rates of seronegativity among global, Taiwan-born, and non-Taiwan-born pregnant women were 14.0%, 11.9%, and 23.1%, respectively. The seronegativity of rubella antibodies decreased from 28.2% for Taiwan-born women born before September 1971 to 8.0% for those born thereafter. The rates of rubella catch-up immunization among global, Taiwan-born, and non-Taiwan-born pregnant women were 28.6%, 20.5%, and 42.2%, respectively. Our results suggest that substantial numbers of older Taiwan-born women and immigrant women remain susceptible to rubella infection.

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“…De ser cierto lo anterior, las características étnicas de estas comunidades pueden tener alguna relevancia en la protección contra la infección por el virus de la rubéola. Los estudios muestran diferencias significativas entre grupos étnicamente diferentes (38,39). La realización de este estudio antes de la vacunación, aclararía estas dudas.…”

Section: Discussionunclassified

Prevalencia de agentes ToRCH en mujeres indígenas en edad fértil, estado Zulia, Venezuela

et al. 2012

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Contribución de los autores:Francisca M. Monsalve-Castillo: concepción y diseño del trabajo, y redacción del manuscrito. Luciana Costa-León: asesoría técnica. Francisca M. Monsalve-Castillo, Luciana Costa-León y Anais Suárez: analizaron e interpretaron los resultados. María Elena Castellano, Anais Suárez y Ricardo Atencio: recolectaron y obtuvieron los datos. Todos los autores participaron en la revisión crítica y aprobación de la versión final del manuscrito. ARTÍCULO ORIGINAL Resultados.El 85,5 % presentó anticuerpos contra T. gondii, el 95,4 % para rubéola, el 75,2 % para citomegalovirus y el 97,2 % para el virus herpes simple 1 y 2. Se observa que el 21,1 % y el 30,2 % presentaron relación entre la variable aborto y las infecciones por citomegalovirus y virus herpes simple 1 y 2, respectivamente. Conclusiones. Existe alta seroprevalencia de infecciones por los agentes causantes del síndrome ToRCH en mujeres en edad fértil de la etnia indígena yukpa. Las condiciones sanitarias precarias y el consumo de agua contaminada con ooquistes, favorecen la adquisición de la infección por T. gondii. El hacinamiento, el inicio a temprana de edad de la actividad sexual y el número de parejas, pueden incidir en la presencia de citomegalovirus y virus herpes simple 1 y 2.Palabras clave: Toxoplasma, rubéola, citomegalovirus, herpesvirus humano 1, herpesvirus humano 2, estudios seroepidemiológicos, mujer, periodo fértil, población indígena, epidemiología. doi: http://dx.doi.org/10.7705/biomedica.v32i4.749 Prevalence of infectious agents in indigenous women of childbearing age in VenezuelaIntroduction. The ToRCH syndrome includes the following infectious pathogens: Toxoplasma gondii, rubella, cytomegalovirus and herpes simplex virus 1 and 2. In susceptible pregnant women, these pathogens can cause abortions and congenital malformation in the newborn babies. Objective. The seroprevalence of infection by ToRCH agents was determined in women of childbearing age in several Venezuelan Yukpa indigenous communities. Material and methods. In 2007, 109 samples were selected from 151 women with an age range of 14 to 40 years old. The determination of antibodies against ToRCH agents was carried out through the indirect enzyme immunoassay technique by ELISA's technique of Smartest Diagnostics. Results. Of the 109 samples, 85.5% presented antibodies against T. gondii, 95.4% for rubella, 75.2% for cytomegalovirus and 97.2% for and herpes simplex virus 1 and 2. A relationship between abortion and infection by cytomegalovirus and herpes simplex virus 1and 2 was noted in 21.1% and 30.2% of women presented, respectively. Conclusions. The findings show a high prevalence of ToRCH agents in women in childbearing age in Yukpa indigenous communities in Venezuela. Poor sanitary conditions and consumption of water contaminated with oocysts may be an important way of transmission of T. gondii. Overcrowding in the communities, sexual activity at an early age and number of partners and may be related to the presence of cytomegalovirus and herpes simplex...

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Factors associated with low immunity to rubella infection on antenatal screening

Abstract: Programs targeting underimmunised populations for rubella vaccination should focus on overseas-born women, particularly those born in Asia, nulliparous women and also women > 35 years of age.

Cited by 24 publications

References 10 publications

Prevalence of anti-rubella, anti-measles and anti-mumps IgG antibodies in neonates and pregnant women in Catalonia (Spain) in 2013: susceptibility to measles increased from 2003 to 2013

Prevalence of anti-rubella, anti-measles and anti-mumps IgG antibodies in neonates and pregnant women in Catalonia (Spain) in 2013: susceptibility to measles increased from 2003 to 2013

Rubella Seroepidemiology and Catch-up Immunization among Pregnant Women in Taiwan: Comparison between Women Born in Taiwan and Immigrants from Six Countries in Asia

Prevalencia de agentes ToRCH en mujeres indígenas en edad fértil, estado Zulia, Venezuela

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