This analysis aimed to examine the association between remission and quality of life (QOL) in schizophrenia. In post-hoc analyses of the 3-year, prospective, observational Schizophrenia Outpatients Health Outcomes (SOHO) study, we compared the QOL of patients who achieved symptomatic and clinical remission with those who did not, and the factors associated. Symptomatic remission was defined as achieving a score of ≤ 3 on the Clinical Global ImpressionsSchizophrenia (CGI-SCH) scale, maintained for at least 6 months and without hospitalization. QOL was patient self-rated using the European-QOL. Of the 6516 patients analysed, 38% were in symptomatic remission 12 months post-baseline and 52% at 36 months. Functional remission remained fairly constant from 12 months to 36 months (22.4% at both time points). At all visits from 12 to 36 months, patient QOL and social functioning were significantly higher for patients in symptomatic remission. QOL was higher in patients in functional remission compared to those not in functional remission at all time points. Patients with maintained symptomatic remission over the 3-year follow-up had a much greater improvement in QOL than patients with no symptomatic remission or symptomatic remission for part of the period. Factors associated with a better QOL included symptomatic remission, paid employment, socially active, having a higher CGI-SCH cognitive score, good compliance, and a better baseline QOL. Achieving symptomatic remission in schizophrenia is associated with an increase in patient self-perceived QOL, even when adjusting for confounding factors.