Factors associated with multidrug-resistant tuberculosis (MDR-TB) in Bhutan: A nationwide case-control study

Tenzin, Chador; Chansatitporn, Natkamol; Dendup, Tashi; Lhazeen, Karma; Dorji, Tandin; Pelzang, Thinley

doi:10.1371/journal.pone.0236250

Cited by 12 publications

(14 citation statements)

References 20 publications

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“…6 However, a study conducted in Bhutan showed that having more than 2 rooms in the house also emerged to be marginally associated with having MDR-TB. 17 This could be due to differences in the classification of variables and differences in the housing conditions. The occurrence of MDR-TB was strongly associated with the previous treatment with anti-TB drugs.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Multidrug-Resistant Mycobacterium tuberculosis Infection: A Multicenter Study from Southern Ethiopia

Badgeba¹,

Shimbre²,

Gebremichael³

et al. 2022

IDR

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Background: Multidrug-resistant tuberculosis (MDR-TB) continues to be a public health problem. Globally in 2019, a total of 465,000 people developed rifampicin-resistant TB (RR-TB), of which 78% had MDR-TB. There is a paucity of evidence on the determinants of MDR-TB in southern Ethiopia. Hence, this study aimed to assess the determinants of MDR-TB in southern Ethiopia. Methods: A hospital-based case-control study was conducted in southern Ethiopia. The cases were all MDR-TB patients attending TB clinics, and controls were all patients who were declared as cured or treatment completed. The cases were selected by consecutive sampling, and a simple random sampling technique was used for controls. Multivariable logistic regression analysis was done to identify determinants of MDR-TB. Adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were computed, and statistical significance was declared at a P-value less than 5%.

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Section: Discussionmentioning

confidence: 99%

Determinants of Multidrug-Resistant Mycobacterium tuberculosis Infection: A Multicenter Study from Southern Ethiopia

Badgeba¹,

Shimbre²,

Gebremichael³

et al. 2022

IDR

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“…It can be seen that the failure of a history of treatment has a risk of 2.9 times the incidence of MDR TB (aOR= 2.95; 95% CI= 27.3 to 30.1). In addition, it is also relevant to the study conducted by Tenzin (Tenzin et al, 2020) that past history of TB treatment had a 5.9 times risk of MDR TB incidence (aOR= 5.90; 95% CI= 2.55 to 13.64).…”

Section: Discussionmentioning

confidence: 99%

“…In a study conducted in Bhutan, it was shown that previous TB treatment, inadequate sleep duration, and traveling by public transport were risk factors associated with MDR-TB in Bhutan. Strengthening early case detection, strengthening treatment strategies, improving treatment adherence, and raising awareness can help control the growing MDR-TB epidemic (Tenzin et al, 2020). Several of these studies have been carried out in various parts of the world including South Asian countries to determine risk factors for MDR-TB.…”

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confidence: 99%

Meta-Analysis: Risk Factors Associated with Multidrugs-Resistant Tuberculosis (MDR-TB) in Tuberculosis Patients

Andriani

Yuliani

2021

J HEALTH PROMOT BEHAV

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Background: Today, the world not only has to face a higher number of deaths from TB every year, but other challenges arise in the form of drug-resistant TB with risk factors that can affect the incidence of MDR TB, namely treatment-related factors (direct) and other factors (not direct). direct) such as biological, social, economic, and health system factors. The aim of this study was to estimate the risk of HIV infection, smoking and previous medication history on the incidence of MDR TB, with a meta-analysis of primary studies conducted by previous authors. Subjects and Method: This study was conducted using a systematic review and meta-analysis study design using PICO, population: Tuberculosis Patients. Intervention: Risk Factors for HIV Infection, Smoking, and History of Medication. Comparison: no HIV infection, no smoking and no history of medication, Outcome: MDR-TB incidence. The articles used in this study came from 4 databases, namely Pubmed, ScienceDirect, ProQuest and Google scholar. The article keywords are ("Risk factor" or "associated") AND ("Multidrug resistant Tuberculosis" or "MDR TB") AND "Case Control" AND (HIV or Smoke or treatment). The articles included in this study are full paper articles, case-control study designs, 2011-2021 and the size of the relationship between Adj Odds Ratio. Article selection is done using PRISMA. Articles were analyzed using the Review Manager 5.3 application. Results: A total of 20 case-control studies with 18,790 TB patients with details of 4,220 cases and 14,570 controls from 3 America, Africa, and Asia. HIV infection had a risk of 2.05 times in TB patients becoming MDR-TB (aOR = 2.05; 95% CI = 1.03 to 4.07; p= 0.040). Smoking had a 2.2 times risk in TB patients for MDR-TB (aOR= 2.20; 95% CI= 1.87 to 2.59; p<0.001). History of TB treatment had a 9.08 times risk in TB patients to become MDR-TB (aOR=9.08; 95% CI= 5.49 to 15.03; p<0.001). Conclusion: Risk factors for HIV infection, smoking and history of TB treatment increase the incidence of TB to MDR-TB.

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“…Among the most prevalent are poverty, overcrowding, HIV co-infection, diabetes, alcoholism, smoking, cavitary disease and even young age. Thus, in clinical practice, it is essential to assess general risk factors as well as ones speci c to the region of residence of the patients [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Factors Contributing to the High Prevalence of Multidrug- Resistant/Rifampicin-Resistant Tuberculosis: A Study From Russia

Ilia

Dyachenko

Ratmanov

et al. 2021

Preprint

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Background: Rapidly growing prevalence of multidrug-resistant/Rifampicin-resistant tuberculosis (MDR/RR-TB; resistance to Isoniazid and Rifampicin/Isolated resistance to Rifampicin) is putting in jeopardy the WHO End TB strategy. This study aimed to identify factors contributing to the high prevalence of MDR/RR-TB in Khabarovsk krai region of Russia.Methods: A cross-sectional retrospective study was conducted. Clinical, demographic and drug susceptibility testing data on 1440 patients were analyzed. Factors associated with MDR/RR-TB were identified through logistic regression analysis, along with in-depth interviews with eight patients, five healthcare managers and five doctors.Findings: 618 patients (42.9%) were identified with MDR/RR-TB. Patients with a history of imprisonment were 16.53 times (95% CI 5.37 to 50.88,) more likely to have MDR/RR-TB, whereas re-treatment patients were 2.82 times (95% CI 2.16 to 3.66) more likely to have MDR/RR-TB. Other influencing factors included presence of disability (AOR is 2.32, 95% CI 1.38 to 3.89) and cavitary disease (AOR is 1.76, 95% CI 1.37 to 2.25). Poor knowledge, progressive tiredness of prolonged TB treatment and inability to hospitalize infectious patients without their consent were perceived by the interviewees as major influencing factors. Conclusions: Incarceration and treatment history, regardless of outcome, were identified as major factors influencing MDR/RR-TB prevalence. It is essential for TB care system to eliminate legal loopholes, which deprive doctors of means to enforce quarantine procedures and epidemiological surveillance on infected patients, former and current inmates. In addition, increasing people’s awareness of TB, early detection and appropriate treatment of patients with TB are needed for successfully combating MDR/RR-TB.

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Factors associated with multidrug-resistant tuberculosis (MDR-TB) in Bhutan: A nationwide case-control study

Cited by 12 publications

References 20 publications

Determinants of Multidrug-Resistant Mycobacterium tuberculosis Infection: A Multicenter Study from Southern Ethiopia

Determinants of Multidrug-Resistant Mycobacterium tuberculosis Infection: A Multicenter Study from Southern Ethiopia

Meta-Analysis: Risk Factors Associated with Multidrugs-Resistant Tuberculosis (MDR-TB) in Tuberculosis Patients

Factors Contributing to the High Prevalence of Multidrug- Resistant/Rifampicin-Resistant Tuberculosis: A Study From Russia

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