Factors Associated with Operative Recurrence Early After Resection for Crohn’s Disease

Abstract

Earlier recurrence of CD requiring reoperation is associated with specific disease and potentially modifiable operation-related factors such as postoperative complications, i.e., anastomotic leak or intraabdominal abscess. Strategies to reduce recurrence in such patients include the identification of factors that may reduce postoperative complications.

CT Enterography in Evaluating Postoperative Recurrence of Crohn’s Disease after Ileocolic Resection

“…The indications for reoperation in our study were penetrating disease, strictures and anastomotic perforation, and bleeding. These were similar to previous studies 15,23 .…”

“…On the other hand, risk factors for reoperation including fistulizing disease, stricture, and operation-related complications can be better visualized at CTE than at IC. 15 Certainly, the small sample size of the present study may not ensure adequate power to compare Rutgeerts score and CTE score in predicting reoperation. Our study has certain limitations.…”

“…Perianal procedures, and early laparotomy for complications related to the index surgery (e.g., anastomotic leak, bleeding, evisceration, intra-abdominal abscess), or lysis of adhesions were not considered as reoperation for CD. 15 …”

Risk Factors for Repeat Abdominal Surgery in Korean Patients with Crohn's Disease: A Multi-Center Study of a Korean Inflammatory Bowel Disease Study Group

“…In other studies, penetrating behavior was a risk factor for postsurgical recurrence [8, 18-20]. However, Khoury et al [21] reported that stricturing behavior was a risk factor for early reoperation. Concerning disease location, several studies demonstrated that the risk of recurrence was highest in ileocolonic CD and lowest in colonic CD [22-24].…”

Fistula Output Microorganism-Susceptible Antimicrobial Prophylaxis Is Associated with a Lower Risk of Surgical Site Infection in Gastrointestinal Fistula Patients Undergoing One-Stage Definitive Surgery

“…The U.S. Centers for Disease Control and Prevention (CDC) Guideline for the Prevention of Surgical Site Infection is the standard of practice for selecting an optimal anti-microbial prophylaxis (AMP) regimen [8]. Empiric broad-spectrum AMP, mainly with first-or secondgeneration cephalosporins, is administered in most cases, in the hope of targeting the most likely pathogens involved in a specific operative procedure.…”