Factors Associated With Ovarian Preservation in Children and Adolescents With Primary Tumors of Ovary

Pogorelić, Zenon; Jukić, Doroteja Pavan; Jukić, Miro; Mrklić, Ivana

doi:10.1007/s13312-020-1847-1

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…It is well known that acute appendicitis is one of the most common causes of right lower abdominal pain in pediatric patients, but not every pain in that area is caused by acute appendicitis [ 1 ]. Numerous conditions can simulate the clinical presentation of acute appendicitis, like acute gastroenteritis, mesenteric lymphadenitis, torsion of intra-abdominal organs, Meckel’s diverticulitis, Crohn’s disease, enterobiasis, etc [ 1 , 2 , 3 ]. Typical clinical appearance of acute appendicitis is present only in 30–40% of pediatric patients [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Validity of Appendicitis Inflammatory Response Score in Distinguishing Perforated from Non-Perforated Appendicitis in Children

et al. 2021

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Background: This prospective observational study aimed to evaluate the validity of appendicitis inflammatory response (AIR) score in differentiating advanced (perforated) from simple (non-perforated) appendicitis in pediatric patients. Methods: A single-center prospective cross-sectional study was conducted between 1 January 2019 until 1 May 2020 including 184 pediatric patients who underwent appendectomy. Based on the intraoperative finding of advanced (n = 38) or simple (n = 146) appendicitis the patients were divided into two groups. Recipient-operator curve (ROC), with calculation of sensitivity and specificity of best cutoff and the area under the curve (AUC), were used to measure the diagnostic value and the potential for risk stratification of the AIR score, among the patients with simple or advanced acute appendicitis. Results: The median value of the AIR score in the perforated and non-perforated groups was 10 (interquartile range, IQR 9, 11), and was 7 (IQR 6, 9), respectively (p < 0.001). Based on the calculated value of AIR score, the patients were classified with a high precision into low, indeterminate and high risk groups for acute appendicitis (p < 0.001). A cutoff value of ≥9 was demonstrated to serve as a reliable indicator of perforated appendicitis with a sensitivity and a specificity of 89.5% and 71.9%, respectively (AUC = 0.80; 95% CI: 0.719–0.871; p < 0.001). Conclusions: Acute appendicitis can be detected with a high level of sensitivity and specificity using the AIR score. Also, the AIR score may differentiate perforated from non-perforated appendicitis in pediatric patients with a high level of accuracy.

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Section: Introductionmentioning

confidence: 99%

Validity of Appendicitis Inflammatory Response Score in Distinguishing Perforated from Non-Perforated Appendicitis in Children

et al. 2021

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“…Abdominal pain was the most common symptom, which is consistent with Pogorelic et al.’s study. 13 Therefore, adolescent women with abdominal pain should be examined in detail, considered comprehensively and treated promptly.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of 52 adolescent patients with ovarian masses ≥10 cm in diameter

Zhang

Meng

2021

J Int Med Res

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Objective To investigate the clinical characteristics and treatment of large ovarian masses in adolescents. Methods Adolescents with large ovarian masses (≥10 cm in diameter) who were treated in Beijing Obstetrics and Gynecology Hospital from March 2010 to December 2018 were retrospectively assessed. Results Fifty-two female patients (mean age: 16.17±2.04 years [11–19 years]) were included and 19 (36.5%) presented with abdominal pain. The blood flow signal rate in ultrasonography was significantly different among benign, borderline and malignant ovarian masses, unlike strong echo, dotted echo and septation rates. Carbohydrate antigen 125 positivity rates were significantly different among pathological types and the endometriotic cyst group showed the highest value (75.0%). Alpha-fetoprotein positivity rates were also different among pathological types. For ovarian cystectomy, 14 and 32 patients underwent laparotomy and laparoscopy, respectively. Mass diameters were significantly higher in the laparotomy group and the operative duration was significantly shorter in the laparoscopy group. There were no significant differences in intraoperative blood loss or postoperative recurrence rates between the two groups. Conclusion Teratomas constitute the greatest group of large ovarian masses in adolescents. Benign tumors should be treated by laparoscopic resection, while borderline or malignant tumors require individualized treatment of tumors and fertility-sparing treatments.

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“…Строк від 12 годин до 24 годин з початку захворювання залишає лише 20% шансів на збереження статевої гонади. Після 24 годин після початку захворювання шансів на збереження життєздатності органу не залишається [4][5][6]. Перекрут яєчка викликає пошкодження тканини та сперматогенезу через різні гіпотетичні механізми; однак існує спільна думка, що наслідки ішемії, ішемічно-реперфузійного пошкодження та окислювального стресу викликають найбільш руйнівні наслідки [7].…”

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Pathomorphological and immunohistochemical characteristics of the testicle in children with critical ischemia during acute torsion

Volos,

Gorbatyuk,

Veselyi

et al. 2024

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Background. The occurrence of acute torsion of the testicle in children leads to ischemia of the testicle, and in the absence of timely medical assistance - to the loss of the organ. The period from 12 hours to 24 hours from the onset of the disease leaves only a 20% chance of saving the genital gonad. There are still no exact signs of viability of the affected gonad in case of critical ischemia of the testicle due to its torsion. Therefore, the study of the dynamics of changes in morphological structures in the course of acute testicular torsion, morphological and functional disorders resulting from torsion, is of great practical interest, because there is no consensus on the nature and degree of these changes in the affected gonad. Objective: study of the nature and severity of pathomorphological changes and immunohistochemical features of the acute torsion testicle in children within 12.1-24 hours or more from the onset of the disease. Methods. A histological, histochemical, and immunohistochemical study of testicular tissue biopsies taken during the operation of detorsion and orchiopexy, and orchidectomy within 12.1–24 hours or more from the onset of clinical symptoms of acute unilateral torsion in 16 patients was conducted. Results. The morphological study of the gonads showed that the duration of acute torsion of 12.1–24 hours or more is characterized by severe pathological changes found in the testicles. After 18 hours of acute ischemia, tubules were visualized in many fields of view in the form of shadows with the impossibility of identifying the structures due to hemorrhagic or ischemic infarcts. Immunohistochemical typing demonstrated the absence of expression of vimentin and calretinin, which indicated the death of sustentocytes (Sertoli cells) and Leydig cells. With a duration of acute torsion of 12.1-18 hours, a histochemical study of glycogen in the cytoplasm of spermatogonia, spermatocytes, and sustentocytes using the PAS-reaction showed that some cells of the spermatogenic epithelium were characterized by irreversible changes preceding necrosis, although giant multinucleated spermatids with relatively preserved glycogen, which meant there was a minimal chance for saving the gonad. Conclusion. Total duration of symptoms and degree of male gonadal torsion are the main prognostic factors for testicular preservation or necrosis in episodes of torsion. The duration of an acute torsion of 12.1-18 hours, according to morphological research, leaves in 42,9% of cases the presence of a minimal chance of saving the genital gonad. After 18 hours from the onset of acute complete testicular torsion in children, the operation of choice is orchidectomy.

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Factors Associated With Ovarian Preservation in Children and Adolescents With Primary Tumors of Ovary

Cited by 7 publications

References 11 publications

Validity of Appendicitis Inflammatory Response Score in Distinguishing Perforated from Non-Perforated Appendicitis in Children

Validity of Appendicitis Inflammatory Response Score in Distinguishing Perforated from Non-Perforated Appendicitis in Children

Clinical analysis of 52 adolescent patients with ovarian masses ≥10 cm in diameter

Pathomorphological and immunohistochemical characteristics of the testicle in children with critical ischemia during acute torsion

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