Factors associated with potentially harmful drug–drug interactions in older Korean people: A population‐based study

Yoon, Seok Jun; Kim, Jong Sung; Jung, Jin‐Gyu; Ahn, Soon-Ki; Song, Young-Su; Bae, Nam-Kyou; Seon, Jeong Yeon; Kim, Jeonghyun

doi:10.1111/ggi.13495

Cited by 6 publications

(9 citation statements)

References 18 publications

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“…As a study from Korea, co-prescriptions prone to potentially harmful drug-drug interactions specified in the Beers Criteria 2015 were found NSAID, and corticosteroids use was 20.64% in cases. 21 In our study, ıt was only 0.9% of cases.…”

Section: Discussioncontrasting

confidence: 51%

Evaluation of the Rational Analgesic use in elderly adults: A cross-sectional study

Başpınar

Basat

2020

Pak J Med Sci

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Objectives: To assess inappropriate analgesic use (IAU) by comparison of STOPP/START Version-2 and Beers 2019 criteria. Methods: This is a cross-sectional study of 331 elderly patients admitted to family medicine clinics at a tertiary hospital between February and July 2018. Data were collected from face-to-face surveys, including informed patient consent and electronic drug monitoring databases. Results: The presence of IAU by STOPP version2 was higher than the Beers criteria (19.6%, 14.5%, respectively; P<0.04; Z= –2.5) with a moderate agreement (Kappa= 0.458). The number of drugs and pain score were predictors of IAU. The most commonly caused IAU was diclofenac, although naproxen was the most used analgesic. Almost 39% of diclofenac use, 18.5% of naproxen use, and 33% of etodolac use were IAU. Most commonly, IAU reasons were; (i) NSAID use in hearth failure (Beers) (ii) NSAID use with an antiplatelet agent(s) without PPI (STOPP). Conclusions: The difference between criteria in terms of IAU was significant in favor of STOPP V2. doi: https://doi.org/10.12669/pjms.36.5.2331 How to cite this:Baspınar MM, Basat O. Evaluation of the Rational Analgesic use in elderly adults: A cross-sectional study. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.2331 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussioncontrasting

confidence: 51%

Evaluation of the Rational Analgesic use in elderly adults: A cross-sectional study

Başpınar

Basat

2020

Pak J Med Sci

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“…Meanwhile, the majority of DDI prescriptions were co-prescriptions of corticosteroids and NSAIDs. This is consistent with the result of Yoon et al (2018), who also reported that corticosteroid and NSAID co-prescriptions were the most common DDI prescriptions [ 39 ]. However, the study of Yoon et al (2018) did not consider prescriber factors affecting occurrence of DDIs [ 39 ].…”

Section: Discussionsupporting

confidence: 93%

“…This is consistent with the result of Yoon et al (2018), who also reported that corticosteroid and NSAID co-prescriptions were the most common DDI prescriptions [ 39 ]. However, the study of Yoon et al (2018) did not consider prescriber factors affecting occurrence of DDIs [ 39 ]. Among ambulatory care visits by patients aged ≥65 years in 2009 from the Taiwanese National Health Insurance Database, psychotropic drugs and first-generation antihistamines accounted for most of the top 10 PIMs [ 30 ].…”

Section: Discussionsupporting

confidence: 93%

Patient- and Prescriber-Related Factors Associated with Potentially Inappropriate Medications and Drug–Drug Interactions in Older Adults

Jang

Jeong

2021

JCM

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We aimed to evaluate the prevalence of potentially inappropriate medication (PIM) use and drug–drug interactions (DDIs) in older adults and their associated factors. This cross-sectional study used National Health Insurance data of older adults in South Korea. The 2015 AGS Beers Criteria were used to classify PIM use and DDIs. The associations of PIM use and DDIs with patient- and prescriber-related factors were evaluated using multiple logistic regression. Of the older adults who received at least one outpatient prescription (N = 1,277,289), 73.0% and 13.3% received one or more prescriptions associated with PIM use or DDIs, respectively. Chlorphenamine was most commonly associated with PIM, followed by diazepam. Co-prescriptions of corticosteroids and NSAIDs accounted for 82.8% of DDIs. Polypharmacy and mainly visiting surgeons or neurologists/psychiatrists were associated with a higher likelihood of prescriptions associated with PIM use or DDIs. Older age, high continuity of care (COC), and mainly visiting a hospital were associated with a lower likelihood of PIM use or DDIs. Prescriptions associated with PIM use and DDIS were more frequent for low COC patients or those who mainly visited clinics; therefore, patients with these characteristics are preferred intervention targets for reducing prescriptions associated with PIM use and DDIs.

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“…The prevalences of all three were higher in women who were medical aid beneficiaries, visited multiple healthcare centers during the year, visited healthcare centers as outpatients frequently during the year and who were co-prescribed six or more drugs in a single prescription. 9 Common factors influencing the risk of PHDI include female sex, medical aid beneficiary, use of multiple healthcare institutions during the year, frequent outpatient visits during the year and co-prescription of six or more drugs in a single prescription.…”

Section: Factors Associated With Potentially Harmful Drug-drug Interamentioning

confidence: 99%