Factors Associated With Recurrence of Squamous Cell Carcinoma Involving the Temporal Bone

McRackan, Theodore R.; Fang, Te-Yung; Pelosi, Stanley; Rivas, Alejandro; Dietrich, Mary S.; Wanna, George B.; Labadie, Robert F.; Haynes, David S.; Bennett, Marc

doi:10.1177/0003489414524169

Cited by 23 publications

(22 citation statements)

References 16 publications

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“…However, in an 11‐year cohort study, multivariate analysis did not find a robust relationship between large‐caliber PNI and prognosis . Despite these contradictory findings, PNI has been confirmed as a route for invasion of the temporal bone, a rare complication of cutaneous SCC with a poor prognosis . One study reported an incidence of PNI of 84.4% in patients with stages III and IV cutaneous SCC of the auricle who underwent temporal bone resection …”

Section: High‐risk Factors In Cutaneous Squamous Cell Carcinomamentioning

confidence: 98%

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Review of high‐risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines In Oncology

et al. 2016

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Cutaneous squamous cell carcinoma (SCC) is a malignancy that arises from epidermal keratinocytes. Although the majority of cutaneous SCC cases are easily treated without further complication, some behave more aggressively and carry a poor prognosis. These "high-risk" cutaneous SCCs commonly originate in the head and neck and have an increased tendency toward recurrence, local invasion, and distant metastasis. Factors for high-risk cutaneous SCC include large size (>2 cm), a deeply invasive lesion (>2 mm), incomplete excision, high-grade/desmoplastic lesions, perineural invasion (PNI), lymphovascular invasion, immunosuppression, and high-risk anatomic locations. Both the National Comprehensive Cancer Network (NCCN ) and the American Joint Committee on Cancer (AJCC) identify several of these high-risk features of cutaneous SCC. The purpose of this article was to review the high-risk features included in these guidelines, as well as their notable discrepancies and omissions. We also provide a brief overview of current prophylactic measures, surgical options, and adjuvant therapies for high-risk cutaneous SCC. © 2016 Wiley Periodicals, Inc. Head Neck 39: 578-594, 2017.

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Section: High‐risk Factors In Cutaneous Squamous Cell Carcinomamentioning

confidence: 98%

“…In particular, these regions show increased metastatic potential to the parotid and cervical lymph nodes . Additionally, cutaneous SCC in the high‐risk periauricular region is particularly associated with locoregional invasion of the temporal bone …”

Section: High‐risk Factors In Cutaneous Squamous Cell Carcinomamentioning

confidence: 99%

Review of high‐risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines In Oncology

et al. 2016

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“…6,8 Although PFN involvement by lymphatic metastases is documented in the literature, the AFV is not always well dissected in its cranial course, owing to the presence of the marginal mandibular nerve (MMN) in this area, which crosses the vein laterally. 8,9 Iatrogenic injury to the MMN is in fact an aesthetic issue for the patient and a potential cause of medicolegal action. 10 For this reason, in clinical practice, the AFV is often interrupted and ligated, and the cranial portion of the vein is lifted to protect the MMN in a flap consisting of the trunk of the vein and the superficial cervical fascia, which is elevated and reflected superiorly (Hayes Martin maneuver; Figure 2 ).…”

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confidence: 99%

“…Metastases to PFNs from squamous cell cancer have been reported in 3% of temporal bone cancers, 5.5% of tongue cancers, 7% of head and neck skin cancers, 8% of oropharynx cancers, and 7.5% to 35% of oral cavity primaries. 2,8,12…”

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confidence: 99%

Lymph Nodes of the Perimandibular Area and the Hazard of the Hayes Martin Maneuver in Neck Dissection

Tirelli

Marcuzzo

2018

Otolaryngol.--head neck surg.

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Objective To provide an anatomic description of submandibular nodes at risk of being left undissected during neck dissection (ND) and to assess whether the Hayes Martin maneuver is a safe procedure in oncologic surgery of level IB nodes. Study Design Prospective study. Setting Academic medical center. Subjects and Methods We recruited 62 patients who were candidates for level IB ND. Perifacial nodes (PFNs) were identified and their characteristics noted. The Hayes Martin maneuver was simulated, and its oncologic safety was tested. Results The study included 63 NDs. PFNs were identified in 84% of cases: their number ranged from 0 to 5, and their mean greatest diameter was 12.45 mm. Anterior PFNs were found to be in direct contact with the marginal mandibular nerve. In 59% of NDs, the Hayes Martin maneuver would have failed to remove all PFNs. Conclusions The PFNs were identified in 84% of cases and ranged in number from 0 to 5. In some cases, the distinction between retro- and preglandular nodes and PFNs is not useful. The Hayes Martin maneuver may not be oncologically sound for complete treatment of level IB nodes.

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“…Varying recurrence rates for SCC have been reported based on the site of involvement, metastasis, and grade. In a retrospective study, 30% SCCs involving temporal bone were found to recur within an average of 5.8 months [11]. Others have reported lower SCC recurrence rates of 9–15% [12, 13].…”

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confidence: 99%

Cutaneous Human Papillomavirus Infection and Development of Subsequent Squamous Cell Carcinoma of the Skin

Hampras

Reed

Bezalel

et al. 2016

Journal of Skin Cancer

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The role of cutaneous human papillomavirus (HPV) infection in the development of subsequent cutaneous squamous cell carcinoma (SCC) is unknown. Pathologically confirmed cases of SCC (n = 150) enrolled in a previously conducted case-control study were included in a retrospective cohort study to examine the association of cutaneous HPV at the time of SCC diagnosis with the risk of subsequent SCC development. Data on HPV seropositivity, HPV DNA in eyebrow hairs (EB) and SCC tumors were available from the parent study. Incidence of subsequent SCC was estimated using person-years of follow up. Cox Proportional Hazards ratios were estimated to evaluate the associations of both, HPV seropositivity and HPV DNA positivity with subsequent SCC. The five year cumulative incidence of subsequent SCC was 72%. Seropositivity to cutaneous HPV was not associated with the risk of subsequent SCC (HR = 0.83, 95% CI = 0.41–1.67). Any beta HPV infection in EB was associated with reduced risk (HR = 0.30, 95% CI = 0.11–0.78) of subsequent SCC among cases who were positive for beta HPV DNA in tumor tissue. Infection with beta HPV type 2 (HR = 0.32, 95% CI = 0.12–0.86) in EB was associated with reduced risk of subsequent SCC among HPV DNA positive SCCs. In conclusion, beta HPV infection was inversely associated with the risk of subsequent SCC.

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Factors Associated With Recurrence of Squamous Cell Carcinoma Involving the Temporal Bone

Abstract: We have identified multiple factors that are associated with increased recurrence of SCC involving the temporal bone.

Cited by 23 publications

References 16 publications

Review of high‐risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines In Oncology

Review of high‐risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines In Oncology

Lymph Nodes of the Perimandibular Area and the Hazard of the Hayes Martin Maneuver in Neck Dissection

Cutaneous Human Papillomavirus Infection and Development of Subsequent Squamous Cell Carcinoma of the Skin

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