Factors Associated with Remission of Eczema in Children: A Population-based Follow-up Study

Abstract

The aim of this study was to analyse factors associated with remission of atopic dermatitis (AD) in childhood. A population-based AD cohort of 894 children aged 1-3 years from a cross-sectional baseline study in 2000 was followed up in 2005. The association between remission, background, health, lifestyle, and environmental variables was estimated with crude and multivariable logistic regression. At follow-up, 52% of the children had remission. Independent factors at baseline predicting remission were: milder eczema (adjusted odds ratio (aOR), 1.43; 95% confidence interval (95% CI) 1.16-1.77); later onset of eczema (aOR 1.40; 95% CI 1.08-1.80); non-flexural eczema (aOR 2.57; 95% CI 1.62-4.09); no food allergy (aOR 1.51; 95% CI 1.11-2.04), and rural living (aOR 1.48; 95% CI 1.07-2.05). Certain aspects of AD and rural living were important for remission, but despite the initial hypotheses to the contrary, the environmental factors examined in this paper were not substantial predictors of remission.

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

“…6,23,28,31,44,45,48 The duration of AD persistence was significantly higher in females (median: 9.0 years; mean ± SE: 12.7 ± 0.2 years) compared with males (median: 7.0 years; mean±SE: 11.7 ± 0.2 years) (HR 1.15; 95% CI 1.04-1.27; P = .006) (Fig 2, E).…”

“…After review of the titles and abstracts, 9326 were excluded; an additional 634 articles were excluded after full-text review. In total, 46 studies were included in the review, of which 44 had valid frequency data that could be pooled, 7 had valid data to assess the effects of gender, 6,23,28,31,44,45,48 6 for allergen sensitization, 6,17,23,36,40,45 and 3 for baseline AD severity 17,28,40 on disease persistence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is presented in Fig 1. …”

“…40 Finally, a study found that children with AD onset within the first 3 years of life who had less than or equal to 1 or more than 1 night compared with 0 nights per week of being kept awake by their rash had higher rates of persistent AD 5 years later (52.9% and 66.7% vs 42.0%). 28 …”

Clinical practice guidelines for the management of atopic dermatitis 2018

“…They reported that remission was achieved in 52% of children. The authors also reported mild AD, older onset age, no eruption on flexion sides, no food allergies, and living in suburban areas as factors of high remission rate …”

Four Years Prospective Study of Natural History of Atopic Dermatitis Aged 7~8 Years at an Individual Level: A Community-Based Survey by Dermatologists' Skin Examination in Childhood

“…Most of the AD patients are diagnosed before childhood especially in the first year of life2627. One questionnaire-based survey of 7~8 years old Korean children reported the following findings: onset age: <2 years in 43.7% and ≥5 years in 26% of children21.…”