Four Years Prospective Study of Natural History of Atopic Dermatitis Aged 7~8 Years at an Individual Level: A Community-Based Survey by Dermatologists' Skin Examination in Childhood

Kim, Young Jee; Yun, Sook Jung; Lee, Jee-Bum; Kim, Seong‐Jin; Won, Young Ho; Lee, Seung−Chul

doi:10.5021/ad.2016.28.6.684

Cited by 3 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most AD patients are diagnosed with mild disease during childhood ( 2 ). In a 4-year prospective study, Kim et al ( 20 ) found mild severity in 70% of the children with AD.…”

Section: Discussionmentioning

confidence: 98%

Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study

et al. 2022

View full text Add to dashboard Cite

ObjectiveTo evaluate the clinical efficacy of a mixture of probiotics (Lactobacillus and Bifidobacterium) in children and adolescents with atopic dermatitis (AD) and the effects on sensitization, inflammation, and immunological tolerance.MethodsIn this double-blind, randomized, placebo-controlled clinical trial, we enrolled 60 patients aged between 6 months and 19 years with mild, moderate, or severe AD, according to the criteria proposed by Hanifin and Rajka. Patients were stratified to receive one gram per day of probiotics or placebo for 6 months. The primary outcome was a decrease in SCORing Atopic Dermatitis (SCORAD). Secondary outcomes were to assess the role of probiotics on the use of topical and oral medicines (standard treatment), serum IgE levels, skin prick test (SPT), and tolerogenic and inflammatory cytokines. Background therapy was maintained.ResultsForty patients completed the study (24 probiotics, 16 placebo). After treatment for six months, the clinical response was significantly better in the probiotics group; the SCORAD decreased [mean difference (MD) 27.69 percentage points; 95% confidence interval (CI), 2.44–52.94], even after adjustment for co-variables (MD 32.33 percentage points; 95%CI, 5.52–59.13), especially from the third month of treatment on. The reduction of the SCORAD in probiotic group persisted for three more months after the treatment had been discontinued, even after adjustment for co-variables (MD 14.24 percentage points; 95%CI, 0.78–27.70). Patients in the probiotics group required topical immunosuppressant less frequently at 6 and 9 months. No significant changes were found for IgE levels, SPT and cytokines.ConclusionsChildren and adolescents with AD presented a significant clinical response after 6 months with a mixture of probiotics (Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus paracasei, and Bifidobacterium lactis. However, this clinical benefit is related to treatment duration. Probiotics should be considered as an adjuvant treatment for AD.

show abstract

“…Most AD patients are diagnosed with mild disease during childhood ( 2 ). In a 4-year prospective study, Kim et al ( 20 ) found mild severity in 70% of the children with AD.…”

Section: Discussionmentioning

confidence: 98%

Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study

et al. 2022

View full text Add to dashboard Cite

show abstract

A nonlinear transient-dynamics approach to atopic dermatitis: Role of spontaneous remission

Kang,

Hwang,

Lai

et al. 2024

Chaos, Solitons & Fractals

View full text Add to dashboard Cite

DNA methylation profile and expression of the phyllagrin gene in patients with atopic dermatitis: case-control study

Antonova,

Ufimtseva,

Makeev

et al. 2024

Vestnik dermatologii i venerologii

View full text Add to dashboard Cite

Background: Atopic dermatitis (AtD) is one of the most common inflammatory skin diseases, affecting up to 20,0% of children and 2,0–8,0% of adults worldwide. Patients with atopic dermatitis usually have dry skin and itching, they are at higher risk of developing asthma, as well as allergic rhinitis. Features of the clinical course of AtD are associated with both interaction of genes and influence of environmental factors. Studying epigenetic mechanisms could provide understanding of the most likely mechanisms by which environmental factors influence gene expression and contribute to the development of AtD. The aim of the study is to conduct a comprehensive molecular genetic analysis (assessment of the level of global DNA methylation and expression of the filaggrin gene (FLG)) in patients with moderate to severe AtD. Material and methods: The case-control study was conducted from January, 2022, through June 2022. A total of 32 patients with AtD and 6 healthy volunteers were recruited. The level of global DNA methylation in blood samples of patients with AtD and healthy individuals was assessed. The filaggrin gene (FLG) expression was measured by polymerase chain reaction in blood samples. Results: A hypermethylation of the genome in patients with AtD is 2.3 times higher than the methylation of genome in controls (p=0,003). FLG gene (exon 3 position 7-8 and exon 1) expression in patients with AtD is decreased compared to control group. Conclusion: Interaction between genomic changes which are associated with mutations in key barrier and immune genes and environmental factors plays a fundamental role in the AtD pathogenesis. The current study found that the epigenome of AtD patients differs from healthy individuals. The study of pathogenetic mechanisms is the basis for the development of new methods of targeted therapy for this socially significant dermatosis.

show abstract

Four Years Prospective Study of Natural History of Atopic Dermatitis Aged 7~8 Years at an Individual Level: A Community-Based Survey by Dermatologists' Skin Examination in Childhood

Cited by 3 publications

References 25 publications

Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study

Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study

A nonlinear transient-dynamics approach to atopic dermatitis: Role of spontaneous remission

DNA methylation profile and expression of the phyllagrin gene in patients with atopic dermatitis: case-control study

Contact Info

Product

Resources

About