Factors for cognitive impairment in adult epileptic patients

Wang, Lei; Chen, Shenggen; Liu, Changyun; Lin, Wanhui; Huang, Huapin

doi:10.1002/brb3.1475

Cited by 49 publications

(53 citation statements)

References 42 publications

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“…For example, 70% of control group reported having had seizures in the past 2 years, whereas 90% of intervention group reported seizures during the same period. Although the impact of seizure frequency on cognitive function is well known, 50 no difference was observed in baseline values between groups in all cognitive tests performed.…”

Section: Discussionmentioning

confidence: 82%

Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

et al. 2020

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Objective: To examine the effect of 12-week exercise program on cognitive function in people with epilepsy. Methods: Twenty-one physically inactive subjects were randomized into two groups: the exercise group (EG) or the control group (CG). EG performed 12 weeks of combined physical training. CG was advised to maintain usual daily activities. EG received a structured, individually supervised exercise program with two 60-minute sessions per week. Each session included warmup (5-minutes), aerobic (15-20 minutes at 14-17 on Borg scale), strength (2-3 sets, 10-15 repetitions), and 5-minute active stretches. Sociodemographic characteristics, clinical information, memory (Digit Span Test [DST]), executive function (Trail Making Test [TMT] A and B), Stroop Color and Word Test, a verbal fluency task, global cognitive function (Montreal Cognitive Assessment [MoCA]), anthropometric measurements (weight, height, and hip and waist circumferences), cardiorespiratory fitness (maximal oxygen consumption [VO 2 max]), and strength (dynamometer) were measured at baseline and after the 12-week intervention.

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Section: Discussionmentioning

confidence: 82%

Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

et al. 2020

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“…Due to the complexity of the disease, the previous studies assessing cognitive status using MoCA instrument and identifying variables associated with the prevalence of cognitive decline in different population of epilepsy patients also revealed varied results. Wang et al analyzed variables for cognitive decline in epilepsy patients using multiple linear regression analysis and showed that high level of education, good control of seizure, receiving monotherapy of AEDs, and absent of depression were protective variables against cognitive decline in these subjects 21 . Gavrilovic et al examined correlation between demographic and clinical characteristics and cognitive decline among drug-resistant and drugsensitive epilepsy patients in a cohort study and showed that duration of epilepsy, control of seizure, and EEG findings are significant predictors for cognitive decline in these subjects 34 .…”

Section: Discussionmentioning

confidence: 99%

“…The present study employed an unpaired categorical analytical case-control study, hence the sample calculation formula (n 1 =n 2 = {(Z α √2PQ + Z β √(P 1 Q 1 + P 2 Q 2 )):(P 1 -P 2 )} 2 ) was applied to determine the sample size. The lowest prevalence of cognitive impairment in epilepsy patients (P 2 ) was about 30% 21 . If α=0.05, Z α =1.96, β=0.2, Z β =0.84, P 2 =0.3, P 1 -P 2 =0.2, P=(P 1 + P 2 ):2, and Q=1 -P, the sample size required for each group was about 93 using the sample calculation formula mentioned above.…”

Section: Subjectsmentioning

confidence: 92%

Characteristics of Cognitive Status of Epilepsy Patients Treated With Monotherapy of First-Generation Antiepileptic Drugs

Harahap

Rizki

Nurfadia

et al. 2020

MJPHM

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Epilepsy is one of the main health problems in neurology that can lead to cognitive decline. Generally, the epilepsy-associated cognitive decline is influenced by demographic, clinical, and treatment characteristics. This study aimed to determine the characteristics of cognitive status of epilepsy patients who received monotherapy using first-generation antiepileptic drugs (AEDs), namely phenytoin, carbamazepine, and valproic acid. It involved 93 epilepsy patients of Mutiara Sukma Mental Hospital (n=38) and Mataram General Hospital (n=55). Besides, 93 healthy patients were assigned as healthy control group (HC) subjects (n=93). Demographic characteristics collected from epilepsy and HC groups were age, gender, and years of education. Clinical characteristics taken from both groups were MoCA-Ina score. Clinical characteristics taken from epilepsy group were age at epilepsy onset, type of seizure (partial vs generalized), etiology (idiopathic vs structural), first-generation AED used, years of treatment, and cognitive status. The result of the study revealed that there were no significant different between the two groups in the means of age and years of education as well as the frequency of male gender (p>0.05). The mean of MoCA-Ina score of epilepsy group was significantly lower compared with HC group (p<0.05). The frequency of cognitive decline among epilepsy patients was 75.3%. The cognitive functions of epilepsy patients using monotherapy with carbamazepine, phenytoin, or valproic acid was significantly lower compared with healthy subjects. We conclude that there was high prevalence of epilepsy-associated cognitive impairment which was associated with male gender.

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“…Cognitive impairments (Wang, Chen, Liu, Lin & Huang, 2020) are typically associated with epileptic seizures with apparent impairment (Wang, Liu, Liu, Zhang & Wang et al, 2020) and frequent seizures (Hessen, Alfstad, Torgersen & Lossius, 2018). But not in all cases epilepsy is associated with cognitive impairments (Hermann, Loring & Wilson, 2017;Zhou, Chen, Peng & Ouyang, 2016;Galanopoulou, & Moshé, 2015).…”

Section: Introductionmentioning

confidence: 99%

Exploring the Psychological Risk Factors in Children with Epilepsy

Kuqi¹,

Elshani²,

Dervishi³

et al. 2020

OJPR

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There are many factors that aggravate the clinical picture of children diagnosed with epilepsy. Through this study we will explore risk factors related to disease characteristics, cognitive impairments, intelligence and behavioral problems in children with epilepsy. Methods: Based on the medical data of children diagnosed with epilepsy being treated at the Pediatric Neurology Unit, University Hospital of Pristina, and the “Hope” Psychological Outpatient Center in Kosovo, about 100 epileptic children, 55 female and 45 male, aged between 6 and 11 years of school age were administered the Montreal Cognitive Assessment scale (MoCA), Raven’s Standard Progressive Matrices (IQ), and Child Behavior Checklist (CBCL) tests. Results: Children participating in the study reveals a predomination of the generalized epilepsy, which continue to be treated with anti-epileptics for more than 3 years. From them 67% did not show the presence of another co-neurological deficit. Neurological tests show evidences of moderate EEG changes in some children and MRI registrations in 65% of children are unchanged and continue to be treated with 1 or 2 antiepileptic drugs for being under control. Intelligence, cognitive and behavioral problems in cases where they were associated with a number of neuropsychological characteristics increase the risk of a disease aggravation and compromise their overall development. Discussion: We can imply that based on the severity of these concomitant factors of the epileptic conditions, they will constitute a high-risk factor for cognitive problems, low intelligence and the emergence of a number of internalizing and externalizing problems of the child with epilepsy. Conclusions: As a risk factor that increases the level of difficulty of epileptic children in some contexts, including general functioning, school, family and social context, the presence of neurobiological and neuropsychological factors such as issues in internalizing and externalizing behaviors, problems in the cognitive field and the IQ are seen, which is also expected to affect the overall development of children’s quality of life.

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Factors for cognitive impairment in adult epileptic patients

Cited by 49 publications

References 42 publications

Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

Characteristics of Cognitive Status of Epilepsy Patients Treated With Monotherapy of First-Generation Antiepileptic Drugs

Exploring the Psychological Risk Factors in Children with Epilepsy

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