Factors influencing adherence in long‐term use of statins

Warren, James R.; Falster, Michael O.; Fox, D M; Jorm, Louisa

doi:10.1002/pds.3526

Cited by 69 publications

(66 citation statements)

References 41 publications

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“…16 Also, obesity has been linked with good adherence to statin therapy. 10,14 However, results have been inconsistent, with some studies showing no association between adherence and obesity 12,17 or physical activity, 12,14 or even an association between adherence to statins and smoking history. 17 Furthermore, few studies have provided information on the association between lifestyle factors and statin adherence stratified by cardiovascular comorbidity, which may modify these associations.…”

mentioning

confidence: 97%

“…3−5 Patients who adhere to preventive drug treatment are often assumed to also have an otherwise healthier lifestyle than those with poor adherence. 6−8 Accordingly, some studies have found current smoking status 9−14 and high alcohol consumption 14,15 to be associated with nonadherence to lipid-lowering therapy. In a Canadian study involving patients in primary care practices, those who reported regular exercise or a healthy diet had high scores of self-reported statin adherence.…”

mentioning

confidence: 99%

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Lifestyle factors as predictors of nonadherence to statin therapy among patients with and without cardiovascular comorbidities

Halava

Korhonen

Huupponen

et al. 2014

CMAJ

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mentioning

confidence: 97%

mentioning

confidence: 99%

Lifestyle factors as predictors of nonadherence to statin therapy among patients with and without cardiovascular comorbidities

Halava

Korhonen

Huupponen

et al. 2014

CMAJ

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“…These data have been used extensively for health services and pharmacoepidemiological studies 20, 21…”

Section: Methodsmentioning

confidence: 99%

Using Large‐Scale Linkage Data to Evaluate the Effectiveness of a National Educational Program on Antithrombotic Prescribing and Associated Stroke Prevention in Primary Care

Liu¹,

Moorin

Worthington

et al. 2016

JAHA

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BackgroundThe National Prescribing Service (NPS) MedicineWise Stroke Prevention Program, which was implemented nationally in 2009–2010 in Australia, sought to improve antithrombotic prescribing in stroke prevention using dedicated interventions that target general practitioners. This study evaluated the impact of the NPS MedicineWise Stroke Prevention Program on antithrombotic prescribing and primary stroke hospitalizations.Method and ResultsThis population‐based time series study used administrative health data linked to 45 and Up Study participants with a high risk of cardiovascular disease (CVD) to assess the possible impact of the NPS MedicineWise program on first‐time aspirin prescriptions and primary stroke‐related hospitalizations. Time series analysis showed that the NPS MedicineWise program was significantly associated with increased first‐time prescribing of aspirin (P=0.03) and decreased hospitalizations for primary ischemic stroke (P=0.03) in the at‐risk study population (n=90 023). First‐time aspirin prescription was correlated with a reduction in the rate of hospitalization for primary stroke (P=0.02). Following intervention, the number of first‐time aspirin prescriptions increased by 19.8% (95% confidence interval, 1.6–38.0), while the number of first‐time stroke hospitalizations decreased by 17.3% (95% confidence interval, 1.8–30.0).ConclusionsConsistent with NPS MedicineWise program messages for the high‐risk CVD population, the NPS MedicineWise Stroke Prevention Program (2009) was associated with increased initiation of aspirin and a reduced rate of hospitalization for primary stroke. The findings suggest that the provision of evidence‐based multifaceted large‐scale educational programs in primary care can be effective in changing prescriber behavior and positively impacting patient health outcomes.

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“…There was no correlation with income or with the place of residence. 23 Despite the availability of statins in the pharmacy of the health institution, the drug was bought from commercial pharmacies by 83 (23.9%) of the 347 respondents, and bought as complement in the primary SUS network by 70 respondents (20.2%).…”

Section: Caregiver Supportmentioning

confidence: 99%

Patient adherence to ischemic heart disease treatment

Nobre

Domingues²

2017

Rev. Assoc. Med. Bras.

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Introduction:The effectiveness of the treatment of chronic diseases depends on the participation of the patient, influenced by different sociocultural factors, which are not fully recognized by the treatment routine. Objective: To search for some of these factors that hinder or facilitate adherence to treatment and use of healthcare resources, approaching patients with ischemic heart disease. Method: A cross-sectional study was conducted using face-to-face interviews. We applied semi-structured questionnaires to 347 individuals and recorded 141 interviews for qualitative analysis. Descriptors were selected to identify eight categories of analyses. The quantitative data were submitted to descriptive analysis of frequency. Results: Only 2% had good medication adherence according to score on Morisky questionnaire. About 23% bought statins; the others obtained statin in the public health institution. Thirty-six speeches were selected and classified according to the following categories: knowledge about disease and medication, difficulty of acquisition, self management of treatment, difficulties of access to health services, side effect of statins, caregiver support, transportation to health services and concerns about the disease progression. However, it was noticed that about 1/3 of the care outside the research institution can be characterized as an attempt to bring rationalization to the health system. Conclusion: The improved adherence to chronic treatment of ischemic heart disease depends on the establishment of effective flows for referral and counter-referral from one care unit to another, relevant information and clarification of the questions for the patients and the attention of health professionals to the many social and cultural factors involved in treatment adherence. New research should be focused on educational groups by integrated multidisciplinary teams in order to share treatment decisions, thereby increasing the patient's commitment to his own health.

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Factors influencing adherence in long‐term use of statins

Abstract: Poor adherence in long-term use of statins is commonplace, but a number of key predictors-including age, language other than English spoken at home, smoking status and psychological distress-are readily assessable by the prescribing practice.

Cited by 69 publications

References 41 publications

Lifestyle factors as predictors of nonadherence to statin therapy among patients with and without cardiovascular comorbidities

Lifestyle factors as predictors of nonadherence to statin therapy among patients with and without cardiovascular comorbidities

Using Large‐Scale Linkage Data to Evaluate the Effectiveness of a National Educational Program on Antithrombotic Prescribing and Associated Stroke Prevention in Primary Care

Patient adherence to ischemic heart disease treatment

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