Factors Influencing Adherence to Antiretroviral Therapy among People Living with HIV in Coastal South India

Yathiraj, Arjun Banagi; Unnikrishnan, Bhaskaran; Ramapuram, John T; Kumar, Nithin; Mithra, Prasanna; Kulkarni, Vaman; Holla, Ramesh; Bhagawan, Darshan; Thapar, Rekha

doi:10.1177/2325957416661424

Cited by 21 publications

(12 citation statements)

References 24 publications

(50 reference statements)

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“…9 , 12 , 26 , 27 Similarly at-risk alcohol use has been reported to affect HIV antiretroviral adherence in South India. 28 Notably, having household contacts who drank or had at-risk alcohol use did not predict LTFU, suggesting household alcohol use does not drive adherence. Our findings suggest that in this region of India, high rates of at-risk alcohol use are driving outcomes and may subsequently impact transmission and development of drug resistance.…”

Section: Discussionmentioning

confidence: 98%

Predictors of Loss to Follow-Up among Men with Tuberculosis in Puducherry and Tamil Nadu, India

Zhou

Lakshminarayanan

Sarkar

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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Identifying predictors of loss to follow-up (LTFU; treatment lapse ³ 2 months) among people with tuberculosis (TB) may assist programmatic efforts in controlling the spread of TB. Newly diagnosed smear-positive TB patients were enrolled in the Regional Prospective Observational Research for TB study in Puducherry and Tamil Nadu, India. Treatment records were used to identify LTFU of those who were enrolled from May 2014 through December 2017. This nested case-control study evaluated male TB patients. Predictors were assessed using multivariable logistic regression. Of 425 men with TB, 82 (19%) were LTFU. In the adjusted analyses of males, divorced/separated marital status (adjusted odds ratio [aOR] 3.80; 95% CI: 1.39-10.38) and at-risk alcohol use (aOR 1.92; 95% CI: 1.12-3.27) were significant predictors for increased risk of LTFU, and diabetes was a significant predictor for decreased risk of LTFU (aOR 0.52; 95% CI: 0.29-0.92). Of 53 men with recorded date of last treatment visit, 23 (43%) and 43 (81%) had LTFU within the first 2 and first 4 months of treatment, respectively. Addressing at-risk alcohol use and providing more intensive follow-up could lead to improved treatment completion.

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Section: Discussionmentioning

confidence: 98%

Predictors of Loss to Follow-Up among Men with Tuberculosis in Puducherry and Tamil Nadu, India

Zhou

Lakshminarayanan

Sarkar

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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“…A study done by Banagi et al, showed that patients with the absence of opportunistic infection had shown good adherence to ART. 16 Another study by Joshi et al, also showed that participants without opportunistic infections had good medication adherence. 17 In this study, behaviour, trust and confidentiality among health care workers were significantly associated with medication adherence.…”

Section: Discussionmentioning

confidence: 98%

Level of Medication Adherence and its Associated Factors among Patients Receiving Antiretroviral Therapy at a Tertiary Care Hospital in South India

2020

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Introduction: Anti-retro viral drugs are the corner stone of management of human immunodeficiency virus (HIV) infection. Anti-retro viral drugs have been consistently proven to reduce mortality due to HIV. The aim of this study was to identify the level of drug adherence and related challenges for adherence. Methods: A cross- sectional study was conducted in the antiretroviral therapy (ART) clinic of a tertiary care teaching hospital. Patients who were above 18 years of age, on ART for at least six months and underwent counselling before starting ART were included in the study (n = 143). Demographic variables and clinical profile were noted and level of drug adherence and associated factors were assessed using Morisky Green Levine test and check list respectively. Data was analysed in SPSS version 22. Results: Most of the study subjects (89.5%) had high level of medication adherence and 10.5% had medium level adherence. Factors contributing to high adherence level were confidentiality and trust among health workers, concerned about their own health, understanding about the prescribed drugs, idea about disease progression, effectiveness and knowledge of anti-retro viral drugs. Conclusion: Drug adherence was found to be high among HIV- infected patients in this study and various reasons contributed for the high adherence among the study subjects.

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“…According to a meta-analysis, participants from cohesive families have 1.74 times higher adherence ( 28 ). Yathiraj et al ( 30 ) discovered that participants with a strong family support (74%; OR = 3.0, CI = 1.2, 5.2) were more likely to adhere to ART ( p < 0.05) ( 30 ). According to Joseph et al ( 31 ), family support was statistically associated with high ART adherence ( p < 0.01) ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Factors associated with anti-retroviral therapy adherence among patients living with HIV during the COVID-19 pandemic: A cross-sectional study

et al. 2022

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BackgroundThe coronavirus disease (COVID-19) pandemic causes fear and anxiety symptoms on some vulnerable populations such as patients living with human immunodeficiency virus (HIV) (PLWH). Physical distancing (during consultation in the clinic) and isolation restrictions will likely have a negative impact on/disruption to all care continuum services of HIV diseases although healthcare services and access to anti-retroviral therapy (ART) have continued to operate.ObjectiveTo investigate the factors associated with ART adherence among PLWH during the COVID-19 pandemic.MethodologyA cross-sectional study was conducted on 324 PLWH who had been on ART for at least 6 months between June 2020 and January 2021. A semi-structured questionnaire was used to interview participants to collect data on sociodemographic characteristics and other factors.ResultsOf 324 PLWH taking ART, 264 (81.48%) had high adherence (≥95%) and 60 (18.52%) had low adherence (< 95%). Factors independently associated with high ART adherence were employment status (adjusted odds ratio (AOR): 0.030, 95% confidence interval (CI): 0.010–0.088; p < 0.001), type of antiretroviral (ARV) (AOR: 3.101, 95% CI: 1.137–8.456; p = 0.027), family support (AOR: 0.157, 95% CI: 0.052–0.475; p = 0.001), the perception that the COVID-19 pandemic negatively impacts the ability to attend clinics (AOR: 7.339, 95% CI: 1.46–36.79; p = 0.015), and the perception that the COVID-19 pandemic negatively impacts the ability to take ART (AOR: 10.611, 95% CI: 2.98–37.72; p < 0.001).ConclusionsDuring the COVID-19 pandemic, factors associated with high ART adherence among PLWH attending the Hospital of Wangaya in Denpasar, Bali, Indonesia were employment status, ART type [non-fixed dose combination (FDC)], family support, and the perception that the COVID-19 pandemic negatively impacts the ability to attend clinics and to take ART.

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Factors Influencing Adherence to Antiretroviral Therapy among People Living with HIV in Coastal South India

Cited by 21 publications

References 24 publications

Predictors of Loss to Follow-Up among Men with Tuberculosis in Puducherry and Tamil Nadu, India

Predictors of Loss to Follow-Up among Men with Tuberculosis in Puducherry and Tamil Nadu, India

Level of Medication Adherence and its Associated Factors among Patients Receiving Antiretroviral Therapy at a Tertiary Care Hospital in South India

Factors associated with anti-retroviral therapy adherence among patients living with HIV during the COVID-19 pandemic: A cross-sectional study

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