Factors Influencing Adverse Perinatal Outcomes in Pregnancies Achieved Through Use of Assisted Reproductive Technology (ART)

Chung, Karine; Coutifaris, Christos; Chalian, Raffi; Lin, Kat; Castlebaum, A.; Barnhart, Kurt T.

doi:10.1016/j.fertnstert.2005.07.263

Cited by 3 publications

(3 citation statements)

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“…A second case control study by Chung et al attempted to investigate risk factors for adverse outcome in IVF conceptions. 19 These authors found that ovarian hyperstimulation syndrome was associated with an increased risk of adverse outcome, and a thicker endometrial stripe at the time of embryo transfer was protective. They found no effect of etiology of infertility, dose or type of medication used for stimulation, use of embryo-manipulation techniques, or embryo quality on perinatal outcome.…”

Section: Etiology Of Risk In Ivf Conceptionsmentioning

confidence: 99%

The Association of In Vitro Fertilization and Perinatal Morbidity

Kalra

Molinaro

2008

Semin Reprod Med

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In recent years, there has been increasing concern regarding the safety of in vitro fertilization (IVF) because of the potential health impact on these infants. Multiple pregnancy contributes the vast majority of morbidity associated with IVF and, initially, many thought that adverse outcomes after IVF were solely attributable to the high incidence of twin pregnancies. More recently, multiple studies have suggested that IVF singleton pregnancies may be at increased risk for preterm birth, low birth weight, congenital anomalies, perinatal mortality, and several other pregnancy-related complications compared with unassisted singleton pregnancies. We have focused this review on the increased risk of adverse outcomes in IVF singleton conceptions compared with that of unassisted conceptions. The available evidence evaluating the association between IVF and low birth weight, preterm delivery, placental abruption, preeclampsia, congenital anomalies, and perinatal mortality in singleton pregnancies is summarized. In addition, data reporting an increased risk of congenital and chromosomal anomalies after IVF are presented.

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Section: Etiology Of Risk In Ivf Conceptionsmentioning

confidence: 99%

The Association of In Vitro Fertilization and Perinatal Morbidity

Kalra

Molinaro

2008

Semin Reprod Med

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“…In a registry study, singletons conceived spontaneously by subfertile patients were more likely to experience PTB, LBW, and small for gestational age when compared with infants born to fertile patients (23). In addition to the underlying infertility diagnosis, differences in perinatal outcomes have also been associated with increased maternal age and multiple gestations (24,25).…”

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confidence: 99%

Obstetric outcomes in pregnancies resulting from in vitro fertilization are not different in fertile, sterilized women compared to infertile women: A Society for Assisted Reproductive Technology database analysis

Libby

DeVilbiss

Chung

et al. 2021

Fertility and Sterility

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Objective: To compare obstetric and neonatal outcomes resulting from assisted reproductive technology in couples with a history of female sterilization to couples with other infertility diagnoses. Design: Retrospective cohort study. Setting: Not applicable. Patient(s): Fresh, nondonor cycles excluding gestational surrogacy from 2004 to 2013 in the United States. Intervention(s): None. Main Outcome Measure(s): Preterm birth rates and low birth weight rates from in vitro fertilization (IVF) pregnancies in couples with infertility and in couples with prior tubal ligation as their sole indication for IVF. Result(s):The mean ages of fertile women (N ¼ 8,478) and infertile women (N ¼ 371,488) were 35.3 and 34.6 years, respectively. Of the singletons born to parous women (N ¼ 26,463), the incidence of preterm birth was not significantly different in fertile, sterilized couples compared to infertile couples (13.7% vs. 12.0%). The incidence of low birth weight among term singletons was also not significantly different between fertile couples compared to infertile couples (3.5% vs. 3.2%). Conclusion(s):Fertile couples have similar preterm birth and low birth weight rates after IVF compared to infertile couples. This suggests that differences in perinatal outcomes may be due to assisted reproductive technology procedures rather than infertility itself. (Fertil Steril Ò 2021;115:617-26. Ó2020 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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“…Although twin and higher order multiple pregnancies are the main contributors to the morbidities associated with IVF conceptions, studies have indicated that even singleton pregnancies are at increased risk for a number of adverse perinatal outcomes such as preterm birth, low birth weight, congenital anomalies, preeclampsia, placental abruption, perinatal mortality, and several other pregnancy related complications (Wang et al 2000;Ericson and Kallen 2001;Hansen et al 2002;Schieve et al 2002Schieve et al , 2004Jackson et al 2004;Shevell et al 2005;Chung et al 2006;Van Voorhis 2006;Kalra and Molinaro 2008;Kalra et al 2011Kalra et al , 2012Henningsen 2014). The contributing factors underlying these associations are not known, but the observations, particularly in singleton pregnancies, suggest a relationship of adverse outcomes to some aspects of IVF.…”

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confidence: 99%

A Molecular Perspective on Procedures and Outcomes with Assisted Reproductive Technologies

Mainigi

Sapienza

Butts

et al. 2016

Cold Spring Harb Perspect Med

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The emerging association of assisted reproductive technologies with adverse perinatal outcomes has prompted the in-depth examination of clinical and laboratory protocols and procedures and their possible effects on epigenetic regulatory mechanism(s). The application of various approaches to study epigenetic regulation to problems in reproductive medicine has the potential to identify relative risk indicators for particular conditions, diagnostic biomarkers of disease state, and prognostic indicators of outcome. Moreover, when applied genome-wide, these techniques are likely to find novel pathways of disease pathogenesis and identify new targets for intervention. The analysis of DNA methylation, histone modifications, transcription factors, enhancer binding and other chromatin proteins, DNasehypersensitivity and, micro-and other noncoding RNAs all provide overlapping and often complementary snapshots of chromatin structure and resultant "gene activity." In terms of clinical application, the predictive power and utility of epigenetic information will depend on the power of individual techniques to discriminate normal levels of interindividual variation from variation linked to a disease state. At present, quantitative analysis of DNA methylation at multiple loci seems likely to hold the greatest promise for achieving the level of precision, reproducibility, and throughput demanded in a clinical setting.

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Factors Influencing Adverse Perinatal Outcomes in Pregnancies Achieved Through Use of Assisted Reproductive Technology (ART)

Cited by 3 publications

References 0 publications

The Association of In Vitro Fertilization and Perinatal Morbidity

The Association of In Vitro Fertilization and Perinatal Morbidity

Obstetric outcomes in pregnancies resulting from in vitro fertilization are not different in fertile, sterilized women compared to infertile women: A Society for Assisted Reproductive Technology database analysis

A Molecular Perspective on Procedures and Outcomes with Assisted Reproductive Technologies

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