Obstetric outcomes in pregnancies resulting from in vitro fertilization are not different in fertile, sterilized women compared to infertile women: A Society for Assisted Reproductive Technology database analysis

Abstract

Objective: To compare obstetric and neonatal outcomes resulting from assisted reproductive technology in couples with a history of female sterilization to couples with other infertility diagnoses. Design: Retrospective cohort study. Setting: Not applicable. Patient(s): Fresh, nondonor cycles excluding gestational surrogacy from 2004 to 2013 in the United States. Intervention(s): None. Main Outcome Measure(s): Preterm birth rates and low birth weight rates from in vitro fertilization (IVF) pregnancies in couples with infertility and in couples with prior tubal ligation as their sole indication for IVF. Result(s):The mean ages of fertile women (N ¼ 8,478) and infertile women (N ¼ 371,488) were 35.3 and 34.6 years, respectively. Of the singletons born to parous women (N ¼ 26,463), the incidence of preterm birth was not significantly different in fertile, sterilized couples compared to infertile couples (13.7% vs. 12.0%). The incidence of low birth weight among term singletons was also not significantly different between fertile couples compared to infertile couples (3.5% vs. 3.2%). Conclusion(s):Fertile couples have similar preterm birth and low birth weight rates after IVF compared to infertile couples. This suggests that differences in perinatal outcomes may be due to assisted reproductive technology procedures rather than infertility itself. (Fertil Steril Ò 2021;115:617-26. Ó2020 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

Association of infertility cause with perinatal outcomes in a freeze-all policy: an analysis including 10,151 singleton newborns

“…Some researchers chose male factor infertility as a control 19 , 49 , whereas others selected unexplained infertility as a reference group 18 , 34 , and a quite recent study adopted women with previous tubal ligation as their control group. 50 The decision regarding the choice of unexplained infertility as a control group in the present study was not just based on previous literature but also on the studies showing that the overall perinatal outcomes among couples with unexplained infertility treated by IVF were good and with similar outcomes compared with spontaneous pregnancies. 51 …”