Factors influencing alopecia areata treatment decisions: A qualitative assessment

Han, Jaehee; Faletsky, Adam; Ghatnekar, Shilpa; Lee, Karen J.; Pérez-Chada, Lourdes M.; Li, Sara J.; Manjalay, Priya; Senna, Maryanne M.; Huang, Kathie P.; Mostaghimi, Arash

doi:10.1016/j.jdin.2022.10.007

Cited by 5 publications

(1 citation statement)

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“…In cases of limited or no clinical efficacy of the above treatments, surgical procedures, hair transplantation, and hair follicle cell transplantation may be considered [15]. The treatment approach for alopecia areata should be tailored by physicians based on the specific circumstances of each patient to achieve optimal therapeutic outcomes [16]. However, a complete cure for alopecia areata is not yet available.…”

Section: Introductionmentioning

confidence: 99%

MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata

Wang,

Ma,

et al. 2023

IJMS

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Alopecia areata is an autoimmune disease characterized by the immune system attacking self hair follicles, mainly in the scalp. There is no complete cure, and the pathogenesis is still not fully understood. Here, sequencing of skin tissues collected from 1-month-old coarse- and fine-wool lambs identified miR-199a-3p as the only small RNA significantly overexpressed in the fine-wool group, suggesting a role in hair follicle development. MiR-199a-3p expression was concentrated in the dermal papillae cells of sheep hair follicles, along with enhanced β-catenin expression and the inhibition of PTPRF protein expression. We also successfully constructed a mouse model of alopecia areata by intracutaneous injection with an miR-199a-3p antagomir. Injection of the miR-199a-3p agomir resulted in hair growth and earlier anagen entry. Conversely, local injection with the miR-199a-3p antagomir resulted in suppressed hair growth at the injection site, upregulation of immune system-related genes, and downregulation of hair follicle development-related genes. In vivo and in vitro analyses demonstrated that miR-199a-3p regulates hair follicle development through the PTPRF/β-catenin axis. In conclusion, a mouse model of alopecia areata was successfully established by downregulation of a small RNA, suggesting the potential value of miR-199a-3p in the study of alopecia diseases. The regulatory role of miR-199a-3p in the PTPRF/β-catenin axis was confirmed, further demonstrating the link between alopecia areata and the Wnt-signaling pathway.

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Section: Introductionmentioning

confidence: 99%