Factors influencing bacteraemia in patients with isomerism and CHD: the effects of functional splenic status and antibiotic prophylaxis

Abstract

Specific factors such as splenic anatomy, atrial appendage isomerism, and antibiotic prophylaxis status are not significantly associated with the risk of bacteraemia in patients with CHD and isomerism. Nosocomial infections represent a majority of bacteraemia in these patients.

Practice variability in management of infectious issues in heterotaxy: A survey of pediatric cardiologists

“…For those with absence of a spleen and those who demonstrated functional asplenia and remained on prophylactic antibiotics after 2 years of age, prophylactic antibiotics should be continued until 5 years of age. Data from the sickle cell population as well as isomerism population demonstrates that it should be safe to discontinue prophylaxis at this age …”

“…Data from the sickle cell population as well as isomerism population demonstrates that it should be safe to discontinue prophylaxis at this age. 20,21,25 Our survey has limitations. The survey was specifically designed for this study and has not undergone previous validation.…”

Unravelling the complexity of heterotaxy syndrome

“…Both asplenia and polysplenia are thought to have functional asplenia which invariably results in an increased risk for infection by encapsulated organisms requiring antibiotic prophylaxis (usually penicillin or amoxycillin). They should additionally receive pneumococcal and meningococcal vaccines in addition to routine immunisation 8. Also, it is important to consider the comorbidity of PCD, a rare genetic disorder affecting ciliary function commonly associated with heterotaxy syndrome.…”

Atención odontopediátrica en niños con síndrome de Heterotaxia Visceral Asplénica (HVA). Una revisión narrativa

“…14 Es nuestra labor profesional asegurarnos de solicitar el cuadro de vacunación, en niños con asplenia, ya que estos pacientes son más susceptibles a infecciones graves causadas por bacterias encapsuladas tales como: por Neumococos, Meningococos y Haemophilus influenzae tipo B, responsables de la mayoría de los casos de sepsis en pacientes asplénicos, que pueden protegerse mediante inmunizaciones. [15][16][17][18] Los avances en las vacunas significan un éxito en la gran mayoría de las infecciones graves responsables de los casos de sepsis en pacientes asplénicos, debido a la creciente prevalencia de neumococos resistentes a los antibióticos, el uso apropiado de la vacuna antineumocócica e influenza se reduce el riesgo de infección bacteriana secundaria; como la sepsis posesplenectomía. [19][20][21][22][23]…”