This study aims to determine the effect of the e-marketing mix (i.e., product, price, place, promotion, people, process) on the level of competitive positional advantage achieved by Micro, Small and Medium Enterprises (MSMEs) in the food sector in the e-marketplaces. The e-marketplaces chosen as the sample areas were e-marketplaces in Indonesia, i.e., Tokopedia, Shopee, and Bukalapak. Respondents involved as samples were food MSMEs that sold snack products in the e-marketplaces, with a total of 174 respondents. The analytical technique employed for this study was Structural Equation Modeling (SEM) analysis. The results of this study indicate that the combination of six e-marketing mix variables (i.e., price and process) did not increase the competitive positional advantage. Meanwhile, other e-marketing mix variables (i.e., product, place, promotion, and people) positively and significantly increased competitive positional advantage. The e-marketing mix variable with the most dominant influence on increasing the competitive positional advantage of food MSMEs in the e-marketplace was the product. Therefore, food MSMEs must pay attention to the product elements, such as optimizing product photos, product variations, product descriptions, and product update information to build a high level of competitive positional advantage in e-marketplaces.