Factors Influencing Fetal Growth

Lubchenco, Lula O.; Hansman, Charlotte; Bäckström, Leena

doi:10.1007/978-94-010-3428-9_10

Cited by 18 publications

(14 citation statements)

References 17 publications

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“…The mean time of delivery was 39.4 + 1.1 (SD) weeks after the first day of the last menstrual period. Mean birthweight of the newborn was 3,300 + 422 (SD) g. This corresponded to the 60th percentile for fetal age and weight, according to Lubchenco [21].…”

Section: Methodsmentioning

confidence: 79%

“…The last four started after the 20th week and received up to 16 Units per day. The mean time of delivery was 38.8 + 1.5 weeks, and the mean birthweight of the newborn was 3,400 + 480 g (75th percentile of Lubchenco [21]). …”

Section: Methodsmentioning

confidence: 99%

“…Delivery was induced at 36.9 +__ 1.5 weeks. The mean birthweight of the newborn was 3,360 + 530 g (90th percentile of Lubchenco [21]). All the babies were born alive.…”

Section: Methodsmentioning

confidence: 99%

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Plasma concentrations of unconjugated estrone, estradiol-17β and estriol, and HCS throughout pregnancy in diabetics and gestational diabetics

Hertogh¹,

Thomas²,

Hoet³

et al. 1976

Diabetologia

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Summary. Plasma unconjugated estrone (E~), estradiol-17/3 (E2) and estriol (E3) , and HCS were measured in the same plasma samples collected throughout pregnancy in 19 gestational diabetics (GD) and 21 diabetics (D). When compared to the results obtained in 22 normal subjects, plasma levels of E 1 and E 2 were significantly elevated in D in the second half of gestation. The results were intermediate although closer to the normals, in GD. E 3 values were not different from the normals in both D and GD. HCS values were lower than normal in early pregnancy in both D and GD. In late pregnancy HCS levels were not different from normal in either D or GD, although some individual values were much above the upper limit in some diabetic patients. The hormonal ratios in D and GD parallel those in normals, although E3/E 2 and HCS/E 2 were lower in D. These results are discussed with respect to the different behaviour of E 2 and E3, taking into accotmt the difference in their respective biosynthetic pathways. Besides a possible quantitative modification of the placental function in D, the results could tentatively be explained by a qualitative change in the fetal estrogen precursors to placental aromatization, in favour of the 16-non-hydroxylated compound. However, maternal modifications in precursor production or in estrogen metabolism can be an alternative hypothesis. Finally, the present work does not support the hypothetical estrogen deficiency in diabetic pregnancy. Estrogen treatment appears to have no objective justification.* This work was presented at the 1 lth annual meeting of the E. A.S.D., Munich September 1975 (Abstract 46, Diabetologia 11, 337, 1975.Key words: Estrone, estradiol, estriol, estrogens, diabetes, pregnancy, HCS, gestational diabetes, plasma levels.The hormonal environment in diabetic pregnancy has been the subject of many investigations, which have been extensively reviewed recently [1,2]. These works were aimed at showing the possible occurrence of endocrine dysfunction of the placenta, induced by the maternal diabetic environment, or of the fetus where adaptative mechanisms might have been stimulated by the particular metabolic situation. Yet, estrogen administration has been advocated as a necessary part of the treatment in diabetic pregnancy [3], in view of inferred hormonal insufficiency based on urine analysis [1,4].Controversy has arisen concerning the significance of urinary measurements [5], and conflicting results were reported [6]. Plasma measurements of estrogens also gave inconclusive results depending on the technique used, or the selection of patients [1,4,7], regarding for instance their state of equilibrium or the degree of illness. Low [8], high [9][10], and normal [11][12][13][14][15] values were reported for plasma estrogens. High [16,17] and normal [18,19] values were found for plasma HCS (human chorionic somatomammotropin).In the present study, unconjugated estrogens (estrone, estradiol-17/3 and estriol) and HCS were measured in the same plasma samples of a group of well tr...

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Section: Methodsmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Plasma concentrations of unconjugated estrone, estradiol-17β and estriol, and HCS throughout pregnancy in diabetics and gestational diabetics

Hertogh¹,

Thomas²,

Hoet³

et al. 1976

Diabetologia

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“…From 24 to 41 weeks, intrauterine growth retardation was stated when the fetus weighed less than the 10th percentile of the curve of Lubchenco et al [10]. From 10 to 24 weeks, we used our own curve [unpublished].…”

Section: Subjects and M Eth O D Smentioning

confidence: 99%

Growth Velocity of Some Fetal Parameters

Guihard-Costa

Larroche

1992

Neonatology

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In this study, fetal growth velocities of the brain weight (whole brain and infratentorial part) and of the right and left fronto-occipital diameters were established from 420 normal fetuses and neonates. The age of the subjects ranged from 10 to 41 gestational weeks. Growth rates were computed by time intervals, and velocity curves were plotted with their 95% confidence intervals. The whole brain displays an accelerating pattern of growth until 35 weeks; thereafter, the growth rate breaks down. The growth velocity of the infratentorial part of the brain increases throughout fetal life, without a fall at 35 weeks. Moreover, it grows faster than the whole brain after 24 weeks. The lengths of the hemispheres present a steady decreasing pattern of growth velocity throughout pregnancy.

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“…There is a discussion in the literature o f the accuracy o f growth charts in assessing adequacy o f fetal growth. Studies by Arbuckle, Wilkins, and Sherman (1993) have questioned current norms of birth weight when used against the Colorado growth chart produced by Lubchenco, Hansman, Dressier, and Boyd (1963 1970-1972 and 1986-1988. Their findings for these time periods demonstrated that "...weight distributions for term deliveries have shifted to higher birth weights;...For preterm deliveries the 90th percentile birth weights have decreased, while the tenth percentile birth weights have remained almost unchanged" (Arbuckle et al, 1993, page 47).…”

Section: Low Birth Weight Infants Definitionmentioning

confidence: 99%

Teen pregnancy and low birthweight infants: An analysis of three regions in northern British Columbia.

Miskelly¹

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This manuscript has been reproduced from the microfilm master. UMl films the text directly from the original or copy submitted. Thus, som e thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.in the unlikely event that the author did not send UMl a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps.

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Factors Influencing Fetal Growth

Cited by 18 publications

References 17 publications

Plasma concentrations of unconjugated estrone, estradiol-17β and estriol, and HCS throughout pregnancy in diabetics and gestational diabetics

Plasma concentrations of unconjugated estrone, estradiol-17β and estriol, and HCS throughout pregnancy in diabetics and gestational diabetics

Growth Velocity of Some Fetal Parameters

Teen pregnancy and low birthweight infants: An analysis of three regions in northern British Columbia.

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