Factors influencing hospital stay duration for patients with mild ischemic colitis: a retrospective study

Huang, Huichao; Wang, Hanyue; Long, Zhe; Wang, Meng; Ding, Junjie; Peng, Jie

doi:10.1186/s40001-022-00665-4

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…The triad of abdominal pain, diarrhea, and rectal bleeding are the classic clinical presentation of ischemic colitis. However, an emphasis on rectal bleeding over abdominal pain, particularly in elderly patients, complicates early diagnosis [25]. In this study, safety signals were detected for ischemic colitis (lower limit of ROR = 32.89, IC-2SD = 4.06).…”

Section: Discussionmentioning

confidence: 65%

A real-world pharmacovigilance analysis of FDA adverse event reporting system database for baloxavir marboxil

Hai,

Wu,

Pan

et al. 2024

Preprint

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Baloxavir marboxil represents a groundbreak drug as the premiere agent targeting influenza with an innovative mechanism of action. The study was to investigate the adverse events and provide reference for clinical safety. The adverse events data were collected from the U.S. FDA Adverse Event Reporting System (FAERS) database covering the first quarter of 2018 to the third quarter of 2023. Two methods, reporting odd ration (ROR) and bayesian confidence propagation neural network (BCPNN) were used to detect the adverse events risk signal. A total of 1671 adverse events reports with baloxavir marboxil as the main suspected drug were collected. More women and patients under 18 years of age were reported. It was found that the adverse events signals involved multiple systems, among which the high-risk signals included melena, altered state of consciousness, delirium, abnormal behavior, rapid severe anaphylaxis, anaphylactic shock and erythema multiforme. Safety warning signs of ischemic colitis and rhabdomyolysis, which were high risk and not mentioned in the instructions, were also detected. In addition to the adverse events recorded in the manual, ischemic colitis, neuropsychiatric symptoms, allergic reactions, severe skin adverse reactions and rhabdomyolysis in the clinical application of baloxavir marboxil also should be paid attention to ensure the safety of patients.

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Section: Discussionmentioning

confidence: 65%

A real-world pharmacovigilance analysis of FDA adverse event reporting system database for baloxavir marboxil

Hai,

Wu,

Pan

et al. 2024

Preprint

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A novel model for predicting prolonged stay of patients with type-2 diabetes mellitus: a 13-year (2010–2022) multicenter retrospective case–control study

Tan

Zhang

et al. 2023

J Transl Med

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Background Length of stay (LOS) is an important metric for evaluating the management of inpatients. This study aimed to explore the factors impacting the LOS of inpatients with type-2 diabetes mellitus (T2DM) and develop a predictive model for the early identification of inpatients with prolonged LOS. Methods A 13-year multicenter retrospective study was conducted on 83,776 patients with T2DM to develop and validate a clinical predictive tool for prolonged LOS. Least absolute shrinkage and selection operator regression model and multivariable logistic regression analysis were adopted to build the risk model for prolonged LOS, and a nomogram was taken to visualize the model. Furthermore, receiver operating characteristic curves, calibration curves, and decision curve analysis and clinical impact curves were used to respectively validate the discrimination, calibration, and clinical applicability of the model. Results The result showed that age, cerebral infarction, antihypertensive drug use, antiplatelet and anticoagulant use, past surgical history, past medical history, smoking, drinking, and neutrophil percentage-to-albumin ratio were closely related to the prolonged LOS. Area under the curve values of the nomogram in the training, internal validation, external validation set 1, and external validation set 2 were 0.803 (95% CI [confidence interval] 0.799–0.808), 0.794 (95% CI 0.788–0.800), 0.754 (95% CI 0.739–0.770), and 0.743 (95% CI 0.722–0.763), respectively. The calibration curves indicated that the nomogram had a strong calibration. Besides, decision curve analysis, and clinical impact curves exhibited that the nomogram had favorable clinical practical value. Besides, an online interface (https://cytjt007.shinyapps.io/prolonged_los/) was developed to provide convenient access for users. Conclusion In sum, the proposed model could predict the possible prolonged LOS of inpatients with T2DM and help the clinicians to improve efficiency in bed management.

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Thirty‑Day Readmission Rates and Outcomes after hospitalization for Ischemic Colitis. A National Analysis

Narvaez,

Martinez,

Kinnucan

et al. 2024

Preprint

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Background/Aim Limited data exists on 30-day readmission rates, readmission causes and predictors following Ischemic Colitis (IC). The aim is to identify etiologies for the above using a national database. Methods A retrospective cohort study using the 2019 National Readmission Database (NRD) of adult patients with an index admission (IA) for IC from January to November and were readmitted within 30 days of discharge was performed. The primary outcome was readmission of any cause. Secondary outcomes were mortality and resource utilization associated with readmission. Independent risk factors for all-cause readmission were identified using Cox regression analysis. Results A total of 6,853 IC patients were identified. Readmission within 30 days occurred in 762 (11%). The primary readmission cause was sepsis. A total of 325 patients died during the IA and additional 30 patients died within 30 days of discharge. Independent predictors of readmission were discharge to short term hospital, a Charlson comorbidity index score ≥ 2 and admission at large size hospital. Having private insurance and undergoing colonoscopy were associated with lower readmission odds. Economic burden of readmission was $12 million in total costs and $51.4 million in total charges. Conclusion Among admitted IC patients, 30-day readmission rate was 11% with half of those secondary to sepsis. Undergoing colonoscopy during the IA is associated with 34% less risk of readmission and disposition to other facilities appears associated with increased early readmission risk. Prospective evaluation to confirm these findings along with development of optimal care strategies to reduce readmission post IC episodes are needed.

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Factors influencing hospital stay duration for patients with mild ischemic colitis: a retrospective study

Cited by 3 publications

References 31 publications

A real-world pharmacovigilance analysis of FDA adverse event reporting system database for baloxavir marboxil

A real-world pharmacovigilance analysis of FDA adverse event reporting system database for baloxavir marboxil

A novel model for predicting prolonged stay of patients with type-2 diabetes mellitus: a 13-year (2010–2022) multicenter retrospective case–control study

Thirty‑Day Readmission Rates and Outcomes after hospitalization for Ischemic Colitis. A National Analysis

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