Purpose: This study aimed to identify the impact of self-efficacy, a health-promoting lifestyle, and social support on, resilience of patients with percutaneous coronary intervention (PCI). Methods: The participants were 146 patients with PCI in a university hospital located in B Metropolitan City. Data were collected from August to October 2023 using a questionnaire on self-efficacy, health-promoting lifestyle, social support, and resilience. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression. Results: The subjects’ average age was 65.73±10.82 years, and men accounted for 76.5%. Resilience showed a statistically significant positive correlation with self-efficacy(r=.82, p<.001), health promoting lifestyle(r=.63, p<.001) and social support (r=.70, p<.001). Total explanatory power was 75% of the total variance in resilience (F=44.70, p<.001). The related factors of resilience were self-efficacy (β=.55, p<.001), social support (β=.27, p<.001), health-promoting lifestyle(β=.17, p=.003), and LDL(β=.10, p=.026). Conclusion: These results should be used as basic data for the development of patient education protocols to improve the resilience of patients with PCI.