Factors influencing the outcome of spontaneous intracerebral haematoma in a Neurosurgical Hospital in South-East Nigeria

Ndubuisi, Chika Anele; Okhueleigbe, Mark; Mbadugha, Tobechi; Ndukuba, Kelechi Onyenekeya; Inojie, Moses Osaodion; Ohaegbulam, Samuel C.

doi:10.4103/npmj.npmj_22_19

Cited by 3 publications

(4 citation statements)

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“…11 , 21 , 24 , 34 The sample size of the included studies was ranged from 36 to 1054. 13 , 36 Of the total studies, most of them (15 studies) were conducted in Eastern Africa 15 , 16 , 19 , 20 , 22 – 24 , 26 – 29 , 31 , 32 , 34 , 37 and eight of them were in Western Africa 12 – 14 , 21 , 30 , 33 , 35 , 36 and the remaining four studies were conducted in Southern Africa 11 , 17 , 18 , 25 ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In this meta-analysis, we performed sensitivity analyses by excluding outliers. 33,36 Hence, the analysis showed that they did not significantly change the extent of pooled outcome measures and heterogeneity (PP = 0.21, 95% CI = 0.17-0.26, I 2 = 96.16%). As a result, we included all the studies for the meta-analysis.…”

Section: Sensitivity and Subgroup Analysesmentioning

confidence: 97%

“… 8 , 10 Several studies were conducted to evaluate the in-hospital mortality rate from acute stroke in sub-Saharan Africa. 11 – 37 However, the mortality rate has not been summarized to reflect the overall in-hospital mortality rate in the region. Hence, this systematic review and meta-analysis aimed to obtain more robust evidence on stroke treatment outcomes from the existing literature in sub-Saharan Africa countries.…”

Section: Introductionmentioning

confidence: 99%

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In-hospital mortality and its predictors among stroke patients in sub-Saharan Africa: A systemic review and meta-analysis

et al. 2021

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Objective: To assess the in-hospital mortality from acute stroke and its predictors in sub-Saharan Africa. Method: The literature search was conducted in the databases of PubMed/Medline, Embase, CINAHL, and Google Scholar. The retrieved studies were screened by titles and abstracts, and then full texts were assessed for eligibility. The methodological quality of the included studies was assessed using the Joanna Briggs Institute’s critical appraisal checklist. The publication bias was assessed using the funnel plot asymmetry and the Egger tests. Data were analyzed using Stata software version 15.0 in a random-effect model. Result: A total of 27 studies with a total sample size of 6331 were included in this systematic review and meta-analysis. The pooled estimated prevalence of in-hospital mortality due to stroke was 22% (95% confidence interval = 0.17–0.27). Stroke mortality in Western Africa (37%, 95% confidence interval = 0.24–0.50) was higher than in Eastern Africa (15%, 95% confidence interval = 0.12–0.19) and Southern Africa (18%, 95% confidence interval = 0.06–0.19). In three studies, mortality was higher in hemorrhagic stroke (25%) than ischemic stroke (14%). Risk factors associated with higher mortality were admission Glasgow Coma Scale, stroke severity, age, sex, presence of hypertension, and declined renal function. Conclusion: The in-patient mortality of stroke in sub-Saharan Africa was high. Therefore, there is an urgent need for further stroke epidemiology studies in stroke subtypes and the performance of patient-level meta-analysis to understand the risk factors associated with mortality and herald appropriate intervention to curb the high mortality rate in the region.

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Section: Resultsmentioning

confidence: 99%

Section: Sensitivity and Subgroup Analysesmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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In-hospital mortality and its predictors among stroke patients in sub-Saharan Africa: A systemic review and meta-analysis

et al. 2021

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“…The frequency of operated patients was 5.8%. Ndubuisi et al [22] reported a significantly higher frequency of about 40.9%. This could be explained by the fact that their study population mainly included patients with severe sICH who were candidates for surgery.…”

Section: Discussionmentioning

confidence: 91%

Management of Spontaneous Intracerebral Haemorrhage (sICH) at the University Hospital of Brazzaville (CONGO)

Hugues Brieux,

Léocia Exaucée,

Josué Euberma

et al. 2024

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Spontaneous intracerebral haemorrhage (sICH) is characterised by bleeding within the brain parenchyma, without any accompanying vascular malformation, parenchymal abnormality or coagulation disorder. The study aimed to depict the management of sICH at the University Hospital of Brazzaville (UHB). It was an observational, descriptive, and cross-sectional analysis. Data collection was conducted retrospectively, covering the period from January 1, 2020 to August 31, 2022, spanning two years and eight months. The study examined socio-demographic, diagnostic, therapeutic, and evolutionary variables. We included 274 cases. We observed 160 men (58.4%) and 114 women (41.6%), resulting in a sex ratio of 1.4. The mean age was 55.3 ± 11.4 years, with ages ranging from 31 to 93 years. The detection of sICH was typically a result of experiencing motor deficits (59.5%) or disorders of consciousness (37.2%). The weightiness of one half of the body was the most common reason for seeking medical advice. Hematoma was capsulo-lenticular in 159 cases (58%) and capsulo-thalamic in 63 cases (23%). Hematomas were <30 ml in 162 cases (59.1%) and >30 ml in 112 cases (40.9%), and associated with hydrocephalus in 11.7% of cases. Conservative medical treatment was administered in 257 cases (94.2%) while surgical treatment was performed in 16 cases (5.8%). The surgical techniques used were external ventricular drainage (EVD) in 2 cases, ventriculo-peritoneal shunt in 5 cases, and hematoma evacuation in 10 cases. Death occurred before the 7th day of hospitalisation in 73 cases (57.8%) and after in 46 cases (42.2%). The median time to death was four days (Q1 = 2 days; Q3 = 7 days

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High Serum Levels of Caspase-3 and Early Mortality in Patients with Severe Spontaneous Intracerebral Hemorrhage

et al. 2020

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Factors influencing the outcome of spontaneous intracerebral haematoma in a Neurosurgical Hospital in South-East Nigeria

Cited by 3 publications

References 1 publication

In-hospital mortality and its predictors among stroke patients in sub-Saharan Africa: A systemic review and meta-analysis

In-hospital mortality and its predictors among stroke patients in sub-Saharan Africa: A systemic review and meta-analysis

Management of Spontaneous Intracerebral Haemorrhage (sICH) at the University Hospital of Brazzaville (CONGO)

High Serum Levels of Caspase-3 and Early Mortality in Patients with Severe Spontaneous Intracerebral Hemorrhage

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