2016
DOI: 10.1111/jvim.14562
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Factors Influencing the Relationship Between the Dose of Amlodipine Required for Blood Pressure Control and Change in Blood Pressure in Hypertensive Cats

Abstract: BackgroundHypertension is a common problem in elderly cats. In most cats, systolic blood pressure (SBP) of <160 mmHg is achieved in response to amlodipine besylate at either 0.625 or 1.25 mg q24h. The individual cat factors determining dose requirement dose have not been explored.AimsTo determine whether individual cat factors influence the dose of amlodipine required to achieve adequate blood pressure control and to determine whether factors other than the prescribed dose of drug alter the achieved plasma aml… Show more

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Cited by 25 publications
(29 citation statements)
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“…Cats requiring an increase in amlodipine dose were found to have significantly higher blood pressure at diagnosis in comparison to those that did not. This finding is in agreement with a recent study, even though not all cats had a follow‐up blood pressure measurement to ensure adequate blood pressure control in our study. Because of inadequate monitoring, it was not possible to investigate the association between blood pressure control and survival after hypertension diagnosis.…”
Section: Discussionsupporting
confidence: 94%
See 1 more Smart Citation
“…Cats requiring an increase in amlodipine dose were found to have significantly higher blood pressure at diagnosis in comparison to those that did not. This finding is in agreement with a recent study, even though not all cats had a follow‐up blood pressure measurement to ensure adequate blood pressure control in our study. Because of inadequate monitoring, it was not possible to investigate the association between blood pressure control and survival after hypertension diagnosis.…”
Section: Discussionsupporting
confidence: 94%
“…Target organ damage is associated with considerable morbidity, including blindness, ventricular hypertrophy, proteinuria, and hypertensive encephalopathy . Amlodipine, a calcium channel blocker, is recommended for the treatment of hypertension and has been found to be effective at decreasing blood pressure in hypertensive cats …”
Section: Introductionmentioning
confidence: 99%
“…Despite the potential role of either the systemic or intrarenal RAAS axis in the pathogenesis or maintenance of hypertension, CCB, specifically amlodipine besylate, have been the first choice for antihypertensive treatment because of established efficacy in cats with idiopathic hypertension or in those with CKD. A mean decrease in SBP of 28‐55 mm Hg typically is observed in cats in hypertensive to severely hypertensive cats .…”
Section: The Hypertensive Patient: Evaluation and Decision To Treatmentioning
confidence: 99%
“…A mean decrease in SBP of 28‐55 mm Hg typically is observed in cats in hypertensive to severely hypertensive cats . Recent data indicate that an initial starting dose of 0.625 mg per cat per day amlodipine besylate is effective in cats in which initial SBP is <200 mm Hg, but that those cats with SBP >200 mm Hg may benefit from a higher starting dosage of 1.25 mg per cat per day . Rarely, dosages of up to 2.5 mg per cat per day however may be required.…”
Section: The Hypertensive Patient: Evaluation and Decision To Treatmentioning
confidence: 99%
“…There are a number of studies assessing the effect of blood pressure on cardiac and renal disease, and survival time of cats with systemic hypertension, but there is very little information available on the rate of retinal reattachment, return of vision, or long‐term visual outcome in cats with hypertensive chorioretinopathy . Thus, the goal of this study was to investigate the factors associated with long‐term visual outcome in cats with retinal disease attributable to systemic hypertension presenting to specialty ophthalmology practices.…”
Section: Introductionmentioning
confidence: 99%