Factors influencing the results of radiotherapy in cases of inoperable endometrial cancer

Rustowski, J; Kupść, W

doi:10.1016/0090-8258(82)90088-9

Cited by 37 publications

(8 citation statements)

References 5 publications

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“…The ECOG performance lated to age [9]. However, Rustowski and Kupsc found that age did not have a statistical impact on survival [15]. In our status is based on strict guidelines and enables the physician to quantitate the patients in a uniform manner.…”

Section: Introductionmentioning

confidence: 97%

“…Fifty-four patients deemed medically inoperable 2 To whom correspondence and reprint requests should be addressed at with clinical Stage I (39 patients) or Stage II (15 Heyman's or Simon's capsule placements were followed by a tandem and Morris plaque or Fletcher-Suit-Delcos applicator (each delivering 2000-4200 mgh) [20][21][22][23][24]. Patients with small uterine cavities which could not accept more than Medical Center.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Radiation Therapy as Exclusive Treatment for Medically Inoperable Patients with Stage I and II Endometrioid Carcinoma of the Endometrium

Fishman¹,

Roberts²,

Chambers³

et al. 1996

Gynecologic Oncology

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Radiation Therapy as Exclusive Treatment for Medically Inoperable Patients with Stage I and II Endometrioid Carcinoma of the Endometrium

Fishman¹,

Roberts²,

Chambers³

et al. 1996

Gynecologic Oncology

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“…advanced endometrial cancer at stage 111 or stage IVa (25)(26)(27). According to the Annual Report, 5-year survival in Sweden is 21'XI for stage 111 and 2Q%) for stage IV.…”

Section: Treatment Of Advanced Endometrial Carcinomamentioning

confidence: 99%

“…Intracavitary and/or external radiotherapy can be used as the only treatment method for patients who, due to age or poor general health, are found to be inoperable (24)(25)(26)(27)(28)(29)(30)(31)(32)(33). Curettage is often used to check treatment results.…”

Section: Inoperable Patients Clinical Stages 1-11mentioning

confidence: 99%

Uterine Cancer (Corpus Uteri)

Einhorn¹

1996

Acta Oncologica

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“…The effect of hemoglobin on the outcome in patients with endometrial [57], prostate [58] and bladder cancer ]59] has also been described. In a study of 488 patients with inoperable endometrial cancer [57], 5-year survival rates were compared within stages I, II or III based upon red blood cell counts (<3.5xl06 versus (3.5-4.0)x 1()6 versus >4.0x 106 [58] reported the influence of hemoglobin and blood pressure levels on the outcome in 914 patients with carcinoma of the prostate at Stanford University. The overall survival of the 146 patients with hemoglobin levels less than 13.5 g/dl was worse (p = 0.02) than that in 505 patients with hemoglobin >13.5 g/dl.…”

Section: Other Cancer Sitesmentioning

confidence: 99%

Blood Transfusion in Patients Receiving Radical Radiotherapy: A Reappraisal

Levine

Vijayakumar

1993

Oncol Res Treat

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Blood transfusion has been widely touted as a useful adjunct to radiation therapy. This is based on the premise that higher hemoglobin levels will increase tissue oxygenation thereby improving the efficacy of therapeutic radiation. Consequently, it has become common clinical practice to transfuse patients undergoing radiotherapy to arbitrary hemoglobin levels. There has been extensive research evaluating the use of transfusion with radiotherapy. Animal data are divided regarding the radiobiologic benefits of transfusion. Clinical experience has established that anemia is a poor prognostic indicator in patients receiving radiotherapy. However, clinical trials have not clearly shown that correction of anemia by transfusion improves the outcomes. This may be explained by adverse effects of transfusion on tumor immunobiology. In addition to the well-known risks of infectious disease, alloimmunization, and allergic reactions, homologous blood has been shown to be immunosuppressive. This immunosuppression has been associated with decreased survival as well as increased rates of recurrence in the treatment of a variety of malignancies, thus making homologous transfusion particularly hazardous for the tumor-bearing patient. This suggests that routine use of transfusion to support patients receiving radiotherapy must be reappraised, and alternative methods of increasing hemoglobin, such as recombinant human erythropoietin (r-HuEPO), need to be considered. r-HuEPO represents a unique opportunity to assess the value of increasing hemoglobin mass without the confounding variable of immunosuppression. Consequently, a prospective clinical trial utilizing r-HuEPO in patients undergoing radiotherapy seems warranted.

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Factors influencing the results of radiotherapy in cases of inoperable endometrial cancer

Cited by 37 publications

References 5 publications

Radiation Therapy as Exclusive Treatment for Medically Inoperable Patients with Stage I and II Endometrioid Carcinoma of the Endometrium

Radiation Therapy as Exclusive Treatment for Medically Inoperable Patients with Stage I and II Endometrioid Carcinoma of the Endometrium

Uterine Cancer (Corpus Uteri)

Blood Transfusion in Patients Receiving Radical Radiotherapy: A Reappraisal

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