Factors Mediating the Impact of Chronic Pruritus on Quality of Life

Carr, C. W.; Veledar, Emir; Chen, Shuo

doi:10.1001/jamadermatol.2013.7696

Cited by 57 publications

(47 citation statements)

References 38 publications

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“…Recent research has been directed at assessing the incidence and prevalence of pruritus (Carr et al 2013;Matterne et al 2013;Shive et al 2013). Pruritus is a symptom of a multitude of diseases, both dermatologic and systemic (Cassano et al 2010).…”

Section: Resultsmentioning

confidence: 99%

“…Other recent studies have utilized QoL instruments to assess the burden of pruritus in various diseases (Chen 2012). Factors shown to mediate the impact of chronic pruritus on QoL include demographic, personality, and pruritus characteristics as well as etiology, gender, and marital status (Desai et al 2008;Kini et al 2011;Ständer et al 2013;Carr et al 2013).…”

Section: Resultsmentioning

confidence: 99%

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Pruritus Epidemiology and Quality of Life

Leader¹,

Carr²,

Chen³

2015

Handbook of Experimental Pharmacology

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The burden of chronic pruritus is increasingly recognized as significant worldwide. As wet-laboratory researchers investigate the pathophysiology of chronic pruritus, epidemiologists and health services researchers are quantifying the impact of pruritus by incidence, prevalence, and quality of life measures. Outcomes researchers are also investigating factors that may predict chronic pruritus incidence and severity. Such efforts will direct resources for research, public health intervention, and clinical care.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Pruritus Epidemiology and Quality of Life

Leader¹,

Carr²,

Chen³

2015

Handbook of Experimental Pharmacology

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“…CP is widely accepted as an important factor influencing HRQoL [2,3,4,5,6,7,9,10,11,12,13,16,19,20,21]. However, factors modifying the respective impact of CP are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies refer to specific pruritic diseases or specific patient groups. Their comparability is limited by heterogeneous methodology and terminology, a lack of widely accepted definitions and varying study end points [10,11,12,13,14,15]. Gender seems to be another relevant aspect for CP-related HRQoL.…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity

Warlich¹,

Fritz

Osada

et al. 2015

Dermatology

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Background: It is unknown if health-related quality of life (HRQoL) differs between diseases associated with chronic pruritus (CP). Objective: To analyze HRQoL in relation to age, gender, skin lesions (primary vs. scratch-induced secondary) and itch intensity. Methods: Consecutive patients of our itch clinic were assessed with the Dermatology Life Quality Index (DLQI) and visual analogue scale (VAS). Results: In 510 CP patients (282 females; median age, 61.4 years), DLQI scores and VAS values were highly correlated, irrespective of the type of skin lesion. Overall, women had a lower HRQoL compared to men (females: 10.7 ± 6.7, males: 8.9 ± 6.7), but female gender was only associated with worse quality of life in patients <65 years old. Conclusion: HRQoL impairment in CP is highly influenced by pruritus intensity but not to the visible skin lesion or underlying cause. With limitations to item bias, DLQI is a suitable instrument for estimating quality of life impairment by CP.

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“…Previous work by Ständer et al (6) and Matterne et al (7) demonstrated that the greater the age, the greater the risk of pruritus. More recently, Carr et al (8) found a negative correlation between age and the effect of chronic pruritus on quality of life in a phone survey population of US veterans. These divergent findings warrant a more detailed characterization of chronic itch in the elderly.…”

mentioning

confidence: 99%

Itch Prevalence and Characteristics in a Hispanic Geriatric Population: A Comprehensive Study Using a Standardized Itch Questionnaire

Valdés‐Rodríguez¹,

Mollanazar²,

González-Muro³

et al. 2015

Acta Derm Venerol

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A cross-sectional study of geriatric patients was performed to provide a comprehensive description of the prevalence and clinical characteristics of chronic itch affecting Hispanic geriatric subjects in Mexico. Participants were recruited from both nursing homes and geriatric ambulatory care centers. Patients without dementia were evaluated using an itch intensity and characteristic questionnaire and were assessed for itch-related dermatoses (n = 302). Data on medications and underlying systemic diseases were obtained from medical records. The prevalence of chronic itch was 25% in this population. Of those with chronic itch, 69% had xerosis, 28% had itch-related dermatoses, and 96% had documented comorbidities. The most common comorbidities were diabetes mellitus (OR = 2.3, 95% CI 1.3-3.9, p = 0.003) and chronic venous insufficiency (OR = 4.4, 95% CI 1.6-12.2, p = 0.002). The most common areas where patients experienced itch were legs (54%), back (45%), scalp (28%) and arms (27%). Patients experienced the greatest amount of itch in the winter (77%) and during the night (65%). Chronic itch is a common problem in the studied Hispanic geriatric population, and its presence significantly correlates with xerosis, diabetes, and venous insufficiency.

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Factors Mediating the Impact of Chronic Pruritus on Quality of Life

Abstract: The multitude of factors that significantly influence the impact of chronic pruritus on quality of life demonstrates the complex nature of this relationship. A better appreciation of these factors will improve the clinical evaluation and treatment of chronic pruritus.

Cited by 57 publications

References 38 publications

Pruritus Epidemiology and Quality of Life

Pruritus Epidemiology and Quality of Life

Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity

Itch Prevalence and Characteristics in a Hispanic Geriatric Population: A Comprehensive Study Using a Standardized Itch Questionnaire

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