Health-Related Quality of Life in Chronic Pruritus: An Analysis Related to Disease Etiology, Clinical Skin Conditions and Itch Intensity

Warlich, Benjamin; Fritz, Fleur; Osada, Nani; Bruland, Philipp; Stumpf, Astrid; Schneider, Gudrun; Dugas, Martin; Pfleiderer, Bettina; Ständer, Sonja

doi:10.1159/000437206

Cited by 55 publications

(50 citation statements)

References 35 publications

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“…In addition, and according to our results, the duration of the skin disease was more than a year in the majority of participants, a finding that could explain higher Skindex‐29 scores in patients with more chronic diseases. This is consistent with previously published studies, which have demonstrated a higher QoL impairment in chronic diseases …”

Section: Discussionsupporting

confidence: 94%

Construct validity and responsiveness of the Colombian version of Skindex‐29

Vásquez

Aguirre

Sanclemente³

2019

Br J Dermatol

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Summary Background In recent years, the need for international, objective, patient‐reported outcomes measures has grown as international collaboration has increased. As most quality‐of‐life scales have been developed in English, there is a growing need to adapt them transculturally to obtain equivalence between the original instrument and the adapted scale. Objectives To assess the construct and convergent–discriminant validity and responsiveness of the Colombian version of Skindex‐29. Methods The cross‐sectional and longitudinal validity and responsiveness were tested in both healthy and dermatology patients. Construct validity was tested through a confirmatory factor analysis. The convergent–discriminant validity was assessed by examining the Spearman correlation coefficient. Change sensitivity was tested by means of the standardized response mean. The effect size and the minimum detectable change were also assessed. Results A total of 265 participants were included; 21·1% were healthy individuals, and 78·9% patients had either inflammatory or noninflammatory skin diseases. Confirmatory factor analysis showed an adequate comparative fit index and Tucker–Lewis index adjustment for the root mean square error of approximation. Convergent validity showed moderate correlations between the emotions, functioning and physical function or physical role domains. Discriminant validity showed low correlations between overall domains for both scales. Sensitivity to change at the first and third month showed effect sizes in global Skindex scores of 0·92 and 0·82, respectively. Conclusions The Colombian version of Skindex‐29 is a valid and clinically sensitive instrument, which can be used for clinical practice and for research to measure the impact of skin diseases on the quality of life of dermatology patients.

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Section: Discussionsupporting

confidence: 94%

Construct validity and responsiveness of the Colombian version of Skindex‐29

Vásquez

Aguirre

Sanclemente³

2019

Br J Dermatol

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“…OR for pain/discomfort and depression/anxiety was 3–8‐fold. Other studies confirm the large impact on HRQoL in patients with chronic pruritus and urticaria …”

Section: Discussionmentioning

confidence: 69%

The burden of common skin diseases assessed with the EQ5D™: a European multicentre study in 13 countries

et al. 2017

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This study confirms the large impact skin conditions have on patients' well-being, differentiating between aspects of HRQoL. Patients with HS, blistering diseases, leg ulcers, infections and most chronic skin diseases reported reduced HRQoL compared with patients with chronic obstructive lung disease, diabetes mellitus, cardiovascular disease and cancers. These findings are important in the prioritization of resource allocation between medical fields and within dermatological subspecialities.

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“…The original validation study of the DLQI included nearly 5% patients with pruritus (nine out of 200) . As all DLQI items refer to impairments due to the skin, it should be used only with care in patients with CP without any skin lesions …”

Section: Methodsmentioning

confidence: 99%