Factors Predicting Long-Term Survival Following Pancreatic Resection for Ductal Adenocarcinoma of the Pancreas: 40 Years of Experience

Abstract

Nearly 20% of patients with pancreas carcinoma who undergo surgical resection have a chance of long-term survival. Survival beyond 5 years is predicted by clinical and tumour-specific factors. Adjuvant chemotherapy might prolong overall survival but is, according to these results, unable to contribute to long-term survival. There is still a risk of recurrence after a 5- or even a 12-year mark. Survival beyond 5 or even 12 years, therefore, does not assure cure.

Pathological tumor size is an independent prognostic factor in pancreatic cancer patients undergoing curative resection followed by adjuvant chemotherapy with S-1

“…There were significant differences (p= 0.0002). Similar results were observed in previous reports 22,23) . In the present study, nodal metastasis was found to be a marginally significant factor according to a univariate analysis, although it did not reach statistical significance in the multivariate analysis.…”

Perioperative Blood Transfusion and the Prognosis of Pancreatic Cancer Surgery: Systematic Review and Meta-analysis

“…Furthermore, three studies reporting on a similar study population as other eligible studies were included in the systematic review but excluded from the subsequent meta-analysis. [18][19][20] Additionally, one study that analyzed patients using the Surveillance, Epidemiology, and End Results (SEER) national cancer database was excluded from the meta-analysis, as it likely included patients from other eligible studies. 18 Therefore, after the exclusion of ineligible studies, 23 original studies (4339 patients) were included in the systematic review.…”

Characteristics of 10-Year Survivors of Pancreatic Ductal Adenocarcinoma

“…First, the intrinsic nature of a population-based study does not allow reevaluation of histologic specimens. However, other authors 3 have noticed that histologic misclassification is identified in less Abbreviation: NOS, not otherwise specified. a The model-based score was derived from the β coefficient • 10/3 and rounded down to the nearest integer.…”

“…5,6 Long-term survivors (LTSs) represent a particular subgroup of patients with PADC that remains poorly understood. In recent years, several studies 3,[7][8][9] have focused on LTSs (surviving ≥10 years) of PADC to characterize a subgroup of patients for whom definitive cure is possible. These studies are often single-institution reports analyzing a limited number of LTSs, often insufficient to reach definitive conclusions.…”