Factors Predicting Survival of Patients with Gastric Cancer

Lin, Wen-Li; Sun, Jialing; Su, Chang; Wu, Peng; Huang, Wen-Tsung; Tsao, Chao‐Jung

doi:10.7314/apjcp.2014.15.14.5835

Cited by 13 publications

(9 citation statements)

References 14 publications

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“…Moreover, the prognosis of affected patients is usually poor due to the fact that most cases are diagnosed after age 50 and presented at advanced stage (Lin et al, 2014, Rahman et al, 2014. Therefore, several efforts have focused on how to prevent the development of gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Improved Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement for Helicobacter pylori Treatment in Thailand

Srinarong¹,

Siramolpiwat²,

Wongcha-um³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Helicobacter pylori (H. pylori) remains an important cause of gastric cancer and peptic ulcer disease worldwide. Treatment of H. pylori infection is one of the effective ways to prevent gastric cancer. However, standard triple therapy for H. pylori eradication is no longer effective in many countries, including Thailand. This study was designed to evaluate the efficacy of adding bismuth and probiotic to standard triple therapy for H. pylori eradication. Materials and Methods: In this prospective single center study, H. pylori infected gastritis patients were randomized to receive 7-or 14-day standard triple therapy plus bismuth with probiotic or placebo. Treatment regimen consisted of 30 mg lansoprazole twice daily, 1 g amoxicillin twice daily, 1 g clarithromycin MR once daily and 1,048mg bismuth subsalicylate twice daily. Probiotic bacteria composed of Bifidobacterium lactis, Lactobacillus acidophilus and Lactobacillus paracasei. Placebo was conventional drinking yogurt without probiotic. CYP2C19 genotyping and antibiotic susceptibility tests were also done. H pylori eradication was defined as a negative 13 C-urea breath test at least 2 weeks after completion of treatment. Results: One hundred subjects were enrolled (25 each to 7-and 14-day regimens with probiotic or placebo). Antibiotic susceptibility tests showed 36.7% metronidazole and 1.1% clarithromycin resistance. CYP2C19 genotyping revealed 40.8%, 49% and 10.2% were rapid, intermediate and poor metabolizers, respectively. The eradication rates of 7-or 14 regimens with probiotics were 100%. Regarding adverse events, the incidence of bitter taste was significantly lower in the 7-day regimen with the probiotic group compared with 7-day regimen with placebo (40% vs. 64%; p=0.04). Conclusions: The 7-day standard triple therapy plus bismuth and probiotic can provide an excellent cure rate of H. pylori (100%) in areas with low clarithromycin resistance such as Thailand, regardless of CYP2C19 genotype. Adding a probiotic also reduced treatment-related adverse events.

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Section: Discussionmentioning

confidence: 99%

Improved Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement for Helicobacter pylori Treatment in Thailand

Srinarong¹,

Siramolpiwat²,

Wongcha-um³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Due to the high incidence of gastric cancer, Japan developed the effective gastric cancer screening and H. pylori eradication program for prevention and early detection of this cancer (Asaka et al, 2014;Lin et al, 2014;Sano et al, 2014). In Thailand, gastric cancer is the sixth most common cancer in males and ninth in females.…”

Section: Clinical Characteristics and Helicobacter Pylori Status Of Gmentioning

confidence: 99%

Clinical Characteristics and Helicobacter pylori Status of Gastric Cancer in Thailand

Vilaichone

Panarat²,

Aekpongpaisit³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The association of nutritional status and mortality has been reported by others, who have used objective and subjective parameters in patients with different types of cancer (32)(33)(34). However, to our knowledge, this is the first study to assess the relationship between weight loss, HGS, and PA and mortality, using regression models, which help control for potential bias.…”

Section: Discussionmentioning

confidence: 89%

Nutritional Status Parameters as Risk Factors for Mortality in Cancer Patients

Maurício

Ribeiro

Correia

2016

Nutrition and Cancer

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The aim of this study was to verify the relationship between weight loss, handgrip strength (HGS) and phase angle (PA) before the beginning of chemotherapy with overall survival in cancer patients. Patients diagnosed with gastrointestinal and breast cancer who were over 18 years old and were scheduled to undergo adjuvant treatment at Hospital Borges da Costa/Brazil were evaluated. The exclusion criteria were neoadjuvant treatment, patients with kidney and liver disease and using diuretics. Weight, HGS and PA tests were performed by trained dietitians. The Kaplan-Meier survival method and the log-rank test, cox regression and ROC curve were used and p < 0.05 was considered significant. Two-hundred and twenty-eight patients were evaluated.The median survival time was higher among the patients who showed weight loss of less than 10% of usual body weight (p < 0.05). Regarding HGS, patients with decreased HGS had a 22.0 month survival versus 34.2 months for those with normal values (p < 0.05). 146 patients had normal PA values, and these patients had increased survival time compared to those with inappropriate values (p < 0.05). In the Cox regression, weight loss and PA were predictors of mortality, HGS wasn't significantly associated with mortality. ROC analysis revealed that weight loss was the nutritional status parameter with the most predictive power.

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Factors Predicting Survival of Patients with Gastric Cancer

Cited by 13 publications

References 14 publications

Improved Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement for Helicobacter pylori Treatment in Thailand

Improved Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement for Helicobacter pylori Treatment in Thailand

Clinical Characteristics and Helicobacter pylori Status of Gastric Cancer in Thailand

Nutritional Status Parameters as Risk Factors for Mortality in Cancer Patients

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