Factors predicting the time until atrial fibrillation recurrence after concomitant left atrial ablation

Grubitzsch, Herko; Grabow, Christian; Orawa, Helmut; Konertz, Wolfgang

doi:10.1016/j.ejcts.2008.03.054

Cited by 18 publications

(14 citation statements)

References 20 publications

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“…Previous investigators have identified that duration of preoperative AF was a significant predictor of late recurrence of AF . We also found that duration of AF >24 months is an independent predictor of recurrence of AF at 24 and 60 months.…”

Section: Discussionsupporting

confidence: 77%

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Active Ganglionated Plexi Is a Predictor of Atrial Fibrillation Recurrence After Minimally Invasive Surgical Ablation

Zheng

Zeng

et al. 2014

J Card Surg

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Section: Discussionsupporting

confidence: 77%

“…Though persistent AF and long‐standing persistent AF are more difficult to treat, in our study the type of AF was not a predictor of recurrence of AF. Many studies also demonstrated that the type of AF did not predict AF recurrence …”

Section: Discussionmentioning

confidence: 99%

Active Ganglionated Plexi Is a Predictor of Atrial Fibrillation Recurrence After Minimally Invasive Surgical Ablation

Zheng

Zeng

et al. 2014

J Card Surg

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“…Some studies have shown that the duration of preoperative AF is associated with postoperative AF recurrence [30,31]. In our study, the duration of AF was not associated with SR maintenance.…”

Section: Discussionsupporting

confidence: 53%

The Role of Matrix Metalloproteinase-2 in the Treatment of Atrial Fibrillation Recurrence after a Radiofrequency Modified Maze Procedure

Wang

Li²,

Liu³

et al. 2013

Cardiology

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Background and Objective: Our study aimed to elucidate the potential clinical and molecular issues in recurrent atrial fibrillation (AF) following a radiofrequency modified maze procedure in patients with rheumatic valvular disease and persistent AF. Methods and Results: Eighty patients with rheumatic valvular disease and persistent AF (lasting more than 6 months) who had undergone a radiofrequency modified maze procedure and mitral valve replacement were enrolled into this single-center pilot study and were followed up for another 6 months. Their clinical characteristics were analyzed and the expression of matrix metalloproteinase (MMP)-2 including its specific inhibitor and collagen volume fraction (CVF) was also assessed. During the 6-month follow-up, 24 subjects had recurrent AF. Among them, the left atrial diameter was larger compared to that achieved in sinus rhythm (SR). The mRNA and protein expression of MMP-2 was significantly increased in recurrent AF patients, while its specific inhibitor did not show a significant difference (p > 0.05). The CVF of type I collagen increased significantly in the recurrent AF patients compared to SR patients (18.16 ± 3.22 vs. 11.66 ± 3.38, p < 0.001), whereas the CVF of type III collagen showed no significant difference (8.33 ± 3.44 vs. 9.55 ± 3.67, p > 0.05). Conclusion: This study suggests that the overexpression of MMP-2 is associated with CVF-I in the left atrial appendage which potentially leads to the recurrence of AF following a radiofrequency modified maze procedure in patients with rheumatic valve disease.

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“…Patients with persistent AF of long duration do not respond as well to medical therapy, or surgical 16 , or catheter ablation. 17 The results of the current study suggest that patients with a longer duration of continuous AF tend to have a higher AF frequency, consistent with more extensive electrical remodeling.…”

Section: Discussionmentioning

confidence: 99%

Left atrial pressure and dominant frequency of atrial fibrillation in humans

et al. 2011

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Background Atrial stretch is thought to play a role in the development of atrial fibrillation (AF). However, the precise mechanism by which stretch contributes to AF maintenance in humans is unknown. Methods The subjects of this study were 58 consecutive patients with persistent AF (n=40) or paroxysmal AF (n=18) undergoing left atrial (LA) ablation. LA pressure was measured before ablation. Both atria and the coronary sinus were mapped, and regional dominant frequency (DF) was determined. Results The mean LA pressure in the persistent AF group was significantly higher than in the paroxysmal AF group (18±5 vs. 10±4 mm Hg, p<0.0001). The mean DF in the persistent AF group was also higher than in the paroxysmal AF group (6.36±0.51 and 5.83±0.54 Hz, p=0.0006). In patients with persistent AF, there was a significant correlation between LA pressure and the DF at the LA appendage (r=0.55, p=0.0002). DFmax was found at the LA appendage region in 24 of the 40 patients (60%) with persistent AF (p=0.0006). In multivariate analysis, LA pressure was the only independent predictor of DFmax in the LA appendage (p=0.04, OR 1.41, 95% CI, 1.02 to 1.94). Conclusions Higher LA pressure in patients with persistent AF implies that these patients are more vulnerable to stretch-related remodeling than patients with paroxysmal AF. The DF of AF was directly related to LA pressure in patients with persistent AF. This suggests that atrial stretch may contribute to the maintenance of AF in humans by stabilizing high frequency sources.

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Factors predicting the time until atrial fibrillation recurrence after concomitant left atrial ablation

Abstract: Preoperative atrial fibrillation duration and left atrial diameter predict the time until atrial fibrillation recurrence after concomitant left atrial ablation, whereas age, type of primary cardiac surgery, ablation technology and antiarrhythmic therapy do not.

Cited by 18 publications

References 20 publications

Active Ganglionated Plexi Is a Predictor of Atrial Fibrillation Recurrence After Minimally Invasive Surgical Ablation

Active Ganglionated Plexi Is a Predictor of Atrial Fibrillation Recurrence After Minimally Invasive Surgical Ablation

The Role of Matrix Metalloproteinase-2 in the Treatment of Atrial Fibrillation Recurrence after a Radiofrequency Modified Maze Procedure

Left atrial pressure and dominant frequency of atrial fibrillation in humans

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