Factors related to compliance to anti-malarial drug combination: example of amodiaquine/sulphadoxine-pyrimethamine among children in rural Senegal

Souares, Aurélia; Lalou, Richard; Sene, Ibra; Sow, Diarietou; Hesran, Jean-Yves Le

doi:10.1186/1475-2875-8-118

Cited by 27 publications

(27 citation statements)

References 14 publications

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“…A similar association was reported in Senegal, where it was concluded that older caregivers spent more time at home, could better attend to younger patients and knew more with regards to administering ACT [14]. It is likely that older respondents may have had prior experience administering or taking AL, which is supported by evidence from this study that indicates respondents who had seen AL before, had the odds 1.46 of adhering fully.…”

Section: Discussionsupporting

confidence: 81%

Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya

Lawford¹,

Zurovac

O'Reilly³

et al. 2011

Malar J

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BackgroundFollowing the development of resistance to anti-malarial mono-therapies, malaria endemic countries in Africa now use artemisinin-based combination therapy (ACT) as recommended first-line treatment for uncomplicated malaria. Patients' adherence to ACT is an important factor to ensure treatment efficacy, as well as to reduce the likelihood of parasite resistance to these drugs. This study reports adherence to a specific ACT, artemether-lumefantrine (AL), under conditions of routine clinical practice in Kenya.MethodThe study was undertaken in Garissa and Bunyala districts among outpatients of five government health facilities. Patients treated with AL were visited at home four days after having been prescribed the drug. Respondents (patients ≥ 15 years and caregivers of patients < 15 years) were interviewed using a standardized questionnaire, AL blister packs were physically inspected and the adherence status of patients was then recorded. Multivariate logistic regression modelling was used to determine predictors of adherence.ResultsOf the 918 patients included in the study, 588 (64.1%) were 'probably adherent', 291 (31.7%) were 'definitely non-adherent' and 39 (4.2%) were 'probably non-adherent'. Six factors were found to be significant predictors of adherence: patient knowledge of the ACT dosing regimen (odds ratio (OR) = 1.76; 95% CI = 1.32-2.35), patient age (OR = 1.65; 95% CI = 1.02-1.85), respondent age (OR = 1.37; 95% CI = 1.10-2.48), whether a respondent had seen AL before (OR = 1.46; 95% CI = 1.08-1.98), whether a patient had reported dislikes to AL (OR = 0.62 95% CI = 0.47-0.82) and whether a respondent had waited more than 24 hours to seek treatment (OR = 0.73; 95% CI = 0.54-0.99).ConclusionOverall, adherence to AL was found to be low in both Garissa and Bunyala districts, with patient knowledge of the AL dosing regimen found to be the strongest predictor of adherence. Interventions aimed at increasing community awareness of the AL dosing regimen, use of child friendly formulations and improving health workers' prescribing practices are likely to ensure higher adherence to AL and eventual treatment success.

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Section: Discussionsupporting

confidence: 81%

Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya

Lawford¹,

Zurovac

O'Reilly³

et al. 2011

Malar J

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“…Souares et al, revealed that, taste, cost and complexity were some of the most considered perspectives of patients in choosing a malaria drug during self-medication in their study in Senegal. 33 This can probably be the case in Ho.…”

Section: Discussionmentioning

confidence: 94%

Patients’ adherence to antimalarial medication; self-report of patients at the Volta regional hospital of Ho, Ghana

et al. 2017

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Background: Despite the advancement in malaria treatments and management; malaria morbidity and mortality is still on the increase. This phenomenon has been mostly attributed to the emergence and transmission resistance of the plasmodium parasite to drugs; which is as a result of non-adherence to anti-malaria medication. Therefore, the purpose of this study was to assess patients’ adherence to anti-malarial medications and the factors influencing their adherence in the Volta regional hospital.Methods: A descriptive cross-sectional study was employed. Convenience sampling technique was used in recruiting respondents. Data were collected within a period of 8 weeks from April to May 2017. Data were analyzed using descriptive statistics in the form of frequencies, percentages, mean and standard deviations which was generated by the use of IBM statistical package for social sciences version 23.Results: The average age of respondents surveyed for this study was 32.27±11.09 ranging from of 19 to 68 years. Majority (51.7%) of respondents were females and 76.7% of them being Christians. The study findings revealed that 36.6% of patient were completely adherent to anti-malarial medication. Over 90% of respondents agreed that the malarial medication had bad taste and it was an unpleasant feeling for them taking it.Conclusions: Poor adherence to antimalaria medications could play a role in the future development of drug resistance. As such, identifying ways to improve anti-malarial compliance will help mitigate drug resistance. Therefore, further studies should be carried out on ways to improve patients’ adherence to antimalarial medication.

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“…Studies have shown that non-prescribed anti-malaria drugs used by the majority of caregivers include chloroquine, amodiaquine, sulphadoxine-pyrimethamine and artemisinin-based combination therapy (ACT) and the dosage regimen taken are incorrect in most cases [4,5]. …”

Section: Introductionmentioning

confidence: 99%

The use of non-prescribed anti-malarial drugs for the treatment of malaria in the Bolgatanga municipality, northern Ghana

Aborah

Akweongo

Adjuik

et al. 2013

Malar J

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BackgroundThe use of non-prescribed anti-malarial drugs can lead to treatment failure and development of drug-resistant parasites. This study investigated the use of non-prescribed anti-malarial drugs for the treatment of malaria in the Bolgatanga Municipality of northern Ghana.MethodsThis was a cross-sectional survey of a random sample of 392 adults and children with episodes of malaria in the last four weeks prior to the study.ResultsMajority of survey respondents 96.9% (380) knew the symptoms of malaria, 75% (294) knew the causes of malaria and 93.1% (365) were aware of mode of transmission of malaria. The use of non-prescribed anti-malarial drugs was 16.8% (95% CI: 13.3-21.0) among the respondents. About 56% (95% CI: 43.3-68.3) of the respondents who took non-prescribed anti-malaria drugs took non-artemisinin-based combination therapy (chloroquine, artemether, amodiaquine and sulphadoxine-pyrimethamine). Respondents above five years of age were more likely to use non-prescribed anti-malarial drugs than those below five years of age [P < 0.001]; respondents who knew the right source of malaria treatment were less likely to use non-prescribed anti-malarial drugs than those who did not [P = 0.002]. Respondents using non-prescribed anti-malarials were influenced by people around them who used non-prescribed anti-malarials. Thus, these respondents were more likely to use non-prescribed anti-malarials than those who were not influenced [P = 0.004].ConclusionsRespondents’ knowledge of malaria treatment and the influence of people using non-prescribed anti-malarials are factors affecting use of non-prescribed anti-malarials. The study concludes that there is high use of non-prescribed anti-malarial drugs in the municipality and most of the non-prescribed anti-malarias were non-artemisinin-based combination therapy. The study recommends education of the general public and chemical sellers to reduce the use of non-prescribe anti-malaria drugs.

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Factors related to compliance to anti-malarial drug combination: example of amodiaquine/sulphadoxine-pyrimethamine among children in rural Senegal

Cited by 27 publications

References 14 publications

Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya

Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya

Patients’ adherence to antimalarial medication; self-report of patients at the Volta regional hospital of Ho, Ghana

The use of non-prescribed anti-malarial drugs for the treatment of malaria in the Bolgatanga municipality, northern Ghana

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