Factors Responsible for Asthma and Rhinitis among Kuwaiti Schoolchildren

Abal, A.T.; Ayed, Adil Ali; Nair, Prithi; Mosawi, M.; Behbehani, Nasser

doi:10.1159/000312716

Cited by 18 publications

(9 citation statements)

References 30 publications

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“…This is surprising given the high frequency of asthma in the general pediatric population [17,18]. On the other hand, almost 30% of patients in the study had at least 1 episode of ACS, but it tended to be mild and had no influence on PFTs.…”

Section: Discussionmentioning

confidence: 90%

“…However, other genetic and environmental factors associated with pulmonary function were not investigated. The reported prevalence rates of wheeze ever, current wheeze, and physician-diagnosed asthma among otherwise normal 13- and 14-year-old Kuwaiti schoolchildren were 13.4, 7.6, and 15.6%, respectively [17,18]. However, there are no reports among younger children or patients with SCD.…”

Section: Introductionmentioning

confidence: 99%

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Correlates of Pulmonary Function in Children with Sickle Cell Disease and Elevated Fetal Hemoglobin

Adekile¹,

Azab²,

Owayed³

et al. 2017

Med Princ Pract

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Objective: The current study was carried out to compare pulmonary function tests (PFTs) in pediatric Kuwaiti sickle cell disease (SCD) patients to age-matched normal controls and to investigate the association of PFTs with selected clinical and laboratory parameters. Subjects andMethods: There were 38 patients with SCD and 36 controls in the study. The patients were recruited from the Pediatric Hematology Clinics of Mubarak Al-Kabeer and Al-Amiri Hospitals, Kuwait, and were studied in steady state. The controls were healthy, non-sickle cell siblings of the patients. Forced expiratory volume in 1 s (FEV₁), forced vital capacity (FVC), total lung capacity, and other PFT parameters were obtained using a constant-volume, variable-pressure, body plethysmograph. Hemoglobin, fetal hemoglobin, serum bilirubin, and lactate dehydrogenase were determined using standard methods. Results: The mean ages of the patients and controls were 10.5 ± 3.2 and 10.5 ± 3.5 years, respectively. The FEV₁% predicted of 84.1 ± 15.4% among the patients was significantly lower than the 92.1 ± 11.8% in the controls (p = 0.003). The FVC% predicted was also significantly lower (p = 0.022) in the patients than in the controls, although the values were generally within the normal range. There was no association of FEV₁ with pain phenotype, acute chest syndrome (ACS), or blood transfusions. Also, there was no significant correlation with reticulocytes, bilirubin, or lactate dehydrogenase. Conclusions: In this study, changes in PFT, especially FEV₁, developed early in the SCD patients. There was no demonstrable association with frequent vaso-occlusive crisis, ACS, and other variables. Hence, there is a need for follow-up studies with serial PFTs to identify vulnerable patients, who might need intervention to prevent early mortality.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Correlates of Pulmonary Function in Children with Sickle Cell Disease and Elevated Fetal Hemoglobin

Adekile¹,

Azab²,

Owayed³

et al. 2017

Med Princ Pract

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“…Two studies (Abal et al 2010;Al-Dawood 2000) reported that many countries in MEA that were impacted by desert dust storms such as Kuwait and Saudi Arabia have a higher prevalence of asthma, particularly in the paediatric population, compared with European countries. Further, a total of 8,157 and 1,131 morbidity and mortality cases were attributed to high PM 10 and PM 2.5 concentrations, respectively, during dust events in Ahvaz (Iran), indicating once more the importance of dust events and their adverse health impacts .…”

Section: Health Assessmentmentioning

confidence: 99%

Concentrations, sources and exposure risks associated with particulate matter in the Middle East Area—a review

Tsiouri

Kakosimos

Kumar

2014

Air Qual Atmos Health

121

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Rapid economic expansion, industrialization, urbanisation and construction in the Middle East Area (MEA) have led to an increase in the levels of air pollution, resulting in serious effects on human health. For the first time, this article provides a comprehensive synthesis of the currently available published information which deals with atmospheric particulate matter (PM) in MEA. The focus of the article remains on the PM sources, monitoring, health impacts and source apportionment.The key objectives are to identify the levels of PM pollution and the associated exposure risks, to highlight research gaps and to discuss future research directions. The limited number of monitoring studies available for MEA indicates that dust storms augmented by the rapid increase in urban population are the key reasons for the high PM concentration levels. The findings of reviewed monitoring studies suggest that the levels of both annual mean PM 10 (20 μg/m 3 ) and PM 2.5 (10 μg/m 3 ) concentrations exceed the World Health Organization (WHO) guidelines during most of the non-dust storm episodes, and as expected, the PM pollution levels become even higher during dust storm episodes. For example, 24-h mean PM 10 concentrations of over 1,000 μg/m 3 were noted during a severe dust storm episode in Kuwait. The findings of the epidemiological and toxicological studies in MEA have shown that dust storm events have a significant impact on respiratory admissions and the adverse health effects of PM are particularly in the form of asthma and respiratory and cardiovascular diseases. It is concluded that PM pollution in MEA is a significant problem and quantification of PM emissions and the design of control measures to abate their impacts on public health are of primary importance. Besides, there is a need for more systematic PM data collection for source apportionment and assessment of PM levels that would enable air pollution-related health impact assessments of MEA. Furthermore, this review highlights that the release of airborne PM from major building activities such as building construction is largely unknown and emission inventories for different situations are needed.

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“…Studies related to dust and health issues were carried out recently by Abdal et al (2010) and Thalib and Al-Taiar (2012). It was found from these studies that dust storms have some impacts on respiratory and asthma admissions in hospitals in Kuwait.…”

Section: Introductionmentioning

confidence: 99%

Probability distribution and extreme value analysis of total suspended particulate matter in Kuwait

et al. 2015

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Probability distribution and extreme value analysis were carried out on total suspended particulate matter (TSP) in Kuwait. The measured TSP data, available for about 10 years from three different locations in Kuwait, viz., Managhesh, Shuwaikh, and Kuwait City were used. For probability distribution analysis, four theoretical distributions were considered, namely Rayleigh, exponential, Gumbel, and log-normal distribution. Based on the study, it was found that log-normal distribution represented the measured daily average TSP value in Kuwait. The expected extreme daily average TSP values for 10-, 25-, 50-, and 100-year return periods were estimated based on Gumbel, exponential, and Weibull extreme value distributions for these three locations. For 100-year return period, the expected TSP values in Managhesh were 5270, 5920, and 4584 μg/m 3 , based on Gumbel, exponential, and Weibull extreme value distributions, respectively. For the same return period, the expected TSP values in Shuwaikh were 11,255, 12, 592, and 8771 μg/m 3 , and in Kuwait City, 7109, 8136, and 6494 μg/m 3 , based on Gumbel, exponential, and Weibull extreme value distributions, respectively. During an extreme dust storm in Kuwait, an extreme TSP of 9619 μg/m 3 was recorded on 25 March 2011. The results of this study are an important input to understand the probability distribution of TSP and also for the analysis on the impact of TSP on the socioeconomic development and on the respiratory health issues in Kuwait.

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Factors Responsible for Asthma and Rhinitis among Kuwaiti Schoolchildren

Cited by 18 publications

References 30 publications

Correlates of Pulmonary Function in Children with Sickle Cell Disease and Elevated Fetal Hemoglobin

Correlates of Pulmonary Function in Children with Sickle Cell Disease and Elevated Fetal Hemoglobin

Concentrations, sources and exposure risks associated with particulate matter in the Middle East Area—a review

Probability distribution and extreme value analysis of total suspended particulate matter in Kuwait

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