Factors that Impact Susceptibility to Fiber-Induced Health Effects

Below, Jennifer E.; Cox, Nancy J.; Fukagawa, Naomi K.; Hirvonen, Ari; Testa, Joseph R.

doi:10.1080/10937404.2011.556052

Cited by 20 publications

(12 citation statements)

References 148 publications

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“…Although asbestos has been banned in many Western countries, it is still used in several parts of the world, and some developing countries are actually increasing the industrial use of asbestos, as well as its production and importation [5], [6], [7]. In Western Europe, over 5,000 people with MPM die each year [8], [9], [10], [11].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

et al. 2013

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Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, only 5–17% of those exposed to asbestos develop MPM, suggesting the involvement of other environmental and genetic risk factors.To identify the genetic risk factors that may contribute to the development of MPM, we conducted a genome-wide association study (GWAS; 370,000 genotyped SNPs, 5 million imputed SNPs) in Italy, among 407 MPM cases and 389 controls with a complete history of asbestos exposure. A replication study was also undertaken and included 428 MPM cases and 1269 controls from Australia.Although no single marker reached the genome-wide significance threshold, several associations were supported by haplotype-, chromosomal region-, gene- and gene-ontology process-based analyses. Most of these SNPs were located in regions reported to harbor aberrant alterations in mesothelioma (SLC7A14, THRB, CEBP350, ADAMTS2, ETV1, PVT1 and MMP14 genes), causing at most a 2–3-fold increase in MPM risk. The Australian replication study showed significant associations in five of these chromosomal regions (3q26.2, 4q32.1, 7p22.2, 14q11.2, 15q14).Multivariate analysis suggested an independent contribution of 10 genetic variants, with an Area Under the ROC Curve (AUC) of 0.76 when only exposure and covariates were included in the model, and of 0.86 when the genetic component was also included, with a substantial increase of asbestos exposure risk estimation (odds ratio, OR: 45.28, 95% confidence interval, CI: 21.52–95.28).These results showed that genetic risk factors may play an additional role in the development of MPM, and that these should be taken into account to better estimate individual MPM risk in individuals who have been exposed to asbestos.

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Section: Introductionmentioning

confidence: 99%

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

et al. 2013

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“…In addition, there has also been research on the difference of susceptibility to fiber-induced health effects based on sex, although the majority has focused on mesothelioma and there is no published data available on the possible role of gender in the development of asbestos-related non-malignant disorders. 20 The non-worker female COPD SMRs were also elevated while non-worker male COPD SMRs were not. This is a new finding since the 2002 Health Consultation by ATSDR, which did not report on any sex-specific SMR elevations for COPD.…”

Section: Discussionmentioning

confidence: 96%

Mortality from asbestos-associated disease in Libby, Montana 1979–2011

Naik

Lewin

Young

et al. 2016

J Expo Sci Environ Epidemiol

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Research on asbestos exposure in Libby, MT, has focused on occupational exposure in vermiculite mining and processing, but less attention has been paid to asbestos-related mortality among community members without vermiculite mining occupational history. Our study reports on asbestos-related mortality in Libby over 33 years (1979–2011) while controlling for occupational exposure. We calculated sex-specific 33-year standardized mortality ratios (SMRs) for Libby residents who died from 1979 to 2011 with an asbestos-related cause of death. Decedent address at time of death was geocoded to confirm inclusion in the Libby County Division. We controlled for past W.R. Grace employment by including and then removing them from the SMR analysis. Six hundred and ninety-four decedents were identified as having at least one asbestos-related cause of death and residing in our study area boundary. Statistically significant (P<0.05) 33-year SMRs, both before and after controlling for W.R. Grace employment, were found for: male and female non-malignant respiratory diseases, female COPD, and asbestosis for both sexes combined. Eighty-five men and two women were matched to employment records. We observed elevated asbestos-related mortality rates among males and females. SMR results for asbestosis were high for both sexes, even after controlling for past W.R. Grace employment. These results suggest that the general population may be experiencing asbestos-related effects, not just former vermiculite workers. Additional research is needed to determine whether SMRs remain elevated after controlling for secondary exposure, such as living with vermiculite workers.

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“…Other suspected factors have also been investigated such as man-made vitreous fibers [Pintos et al, 2009;Rodelsperger et al, 2001], ionizing radiation [Neugut et al, 1997;De Bruin et al, 2009;Goodman et al, 2009;Tubiana, 2009], genetic susceptibility in familial malignant mesothelioma [Dogan et al, 2006;Ascoli et al, 2007;Ugolini et al, 2008;Sahin et al, 2009;Below et al, 2011], and history of non-malignant respiratory disease [Nagai and Toyokuni, 2010] but none of them has yet been established as risk factors. Indeed, assessment of the potential effects of other factors is very difficult owing to the strong effect of and potential confounding from asbestos exposure.…”

Section: Introductionmentioning

confidence: 99%