Factors That Predict the Development of Hypertension in Women With Pregnancy-Induced Hypertension

Shopen, Noa; Schiff, Eyal; Koren‐Morag, Nira; Grossman, Ehud

doi:10.1093/ajh/hpv073

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…Pregnant women aged 35 years and more were at risk of persisting hypertension than those aged below 35 years (aRR=1.14,95% CI:1.131–4.847, p =0.022). This finding was consistent with that of Nakimuli et al 22 and Ndayambagye et al 4 all conducted in Uganda, Shopen et al 23 in Israel as well as the one of Behrens et al 24 in Denmark. Consistently also was the findings of Amougou et al 18 in Cameroon where old age of more than 40 years was independently associated with progression to persistent arterial hypertension in women with preeclampsia.…”

Section: Discussionsupporting

confidence: 91%

<p>Predictors of Postpartum Persisting Hypertension Among Women with Preeclampsia Admitted at Carlos Manuel de Cèspedes Teaching Hospital, Cuba</p>

Tornés

Méndez²,

Aliaga

et al. 2020

IJWH

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so as to guide the health-care providers in early identification of the patients at risk for timely intervention. Patients and Methods: A three-year prospective cohort study was conducted between March 2017 and March 2020. A cohort of 178 women diagnosed with preeclampsia at the hypertension unit of Carlos Manuel de Cèspedes Teaching Hospital were recruited. Interviewer administered questionnaires and laboratory and ultrasound scan result forms were used to collect the data. Binary logistic regression was conducted to determine the predictors. All data analyses were conducted using STATA version 14.2. Results: Forty-five (27.8%) of the studied 162 patients were still hypertensive at 12 weeks postpartum. Maternal age of 35 years or more (aRR=1.14,95% CI:1.131-4.847, p=0.022), early onset preeclampsia (before 34 weeks of gestation) (aRR=7.93, 95% CI:1.812-34.684, p=0.006), and elevated serum creatinine levels of more than 0.8mg/dl (aRR=1.35, 95% CI:1.241-3.606, p=0.032) were the independent predictors of persisting hypertension at 12 weeks postpartum. Conclusion: Recognition of these predictors and close follow-up of patients with preeclampsia will improve the ability to diagnose and monitor women likely to develop persisting hypertension before its onset for timely interventions.

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Section: Discussionsupporting

confidence: 91%

<p>Predictors of Postpartum Persisting Hypertension Among Women with Preeclampsia Admitted at Carlos Manuel de Cèspedes Teaching Hospital, Cuba</p>

Tornés

Méndez²,

Aliaga

et al. 2020

IJWH

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“…Women with pregnancy-induced hypertension had a higher BMI compared with women with a normotensive pregnancy [32]. However, the mechanisms linking obesity to this maternal hypertension are far from understood and thus require studies in animal models.…”

Section: Discussionmentioning

confidence: 99%

Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats

Spradley

Palei²,

Granger³

2016

Journal of Hypertension

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Objectives Although obesity increases the risk for hypertensive disorders of pregnancy, the mechanisms remain unclear. Neural melanocortin-4 receptor (MC4R) deficiency causes hyperphagia and obesity. Effects of MC4R deficiency on body weight, blood pressure (BP) and placental inflammatory responses to high-fat diet (HFD) are unknown. We tested two hypotheses: MC4R deficiency results in higher body weight, BP and placental inflammation under normal-fat diet (NFD) conditions and HFD exaggerates these responses in MC4R-deficient pregnant rats. Methods MC4R+/+ and MC4R+/− rats were maintained on NFD (13% kcal fat) or HFD (40% kcal fat) for ~15 weeks, then measurements made on gestational day 19. Results MC4R+/− pregnant rats had greater body mass and total body fat and visceral adipose tissue weights along with greater circulating total cholesterol (TC) and leptin levels than MC4R+/+ rats regardless of diet. On NFD, circulating adiponectin levels were lower and placental TNFα levels and BP (conscious with carotid catheter) were higher in these heavier rats. Circulating adiponectin levels were lower and placental TNFα levels and BP were higher in MC4R+/+ rats compared with NFD controls. These parameters were not affected by HFD in the already heavier and hypertensive MC4R+/− pregnant rats. Conclusion Obesity in MC4R deficiency and HFD in MC4R+/+ rats result in higher BP and placental inflammation during pregnancy. However, HFD did not exaggerate these responses in already obese MC4R+/− pregnant rats. These data suggest that obesity and HFD are independently related to hypertension and placental inflammation in pregnancy.

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“…We recognize that the requirement might have led to exclusion of women with PIH who later developed chronic hypertension as PIH women have a much increased risk of developing chronic hypertension. 13 In total, 131 (18.6%) of the 703 women studied met the criteria for PIH. For participants who had been examined more than once, we used data in the last survey; the overall agreement for the responses at different occasions was 95.2%.…”

Section: Definition Of Pihmentioning

confidence: 99%

Childhood Risk Factors and Pregnancy-Induced Hypertension: The Bogalusa Heart Study

Xiong

Harville

et al. 2016

AJHYPE

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Factors That Predict the Development of Hypertension in Women With Pregnancy-Induced Hypertension

Abstract: Our findings confirm the association between PIH and chronic HTN. In women with PIH, high BMI and more previous pregnancies are risk factors for developing HTN. Thus, obese women with multiple pregnancies who develop PIH should be more closely followed for the development of HTN.

Cited by 15 publications

References 14 publications

<p>Predictors of Postpartum Persisting Hypertension Among Women with Preeclampsia Admitted at Carlos Manuel de Cèspedes Teaching Hospital, Cuba</p>

<p>Predictors of Postpartum Persisting Hypertension Among Women with Preeclampsia Admitted at Carlos Manuel de Cèspedes Teaching Hospital, Cuba</p>

Differential body weight, blood pressure and placental inflammatory responses to normal versus high-fat diet in melanocortin-4 receptor-deficient pregnant rats

Childhood Risk Factors and Pregnancy-Induced Hypertension: The Bogalusa Heart Study

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