Faecalibacillus intestinalis gen. nov., sp. nov. and Faecalibacillus faecis sp. nov., isolated from human faeces

Seo, Boram; Jeon, Kyungchan; Baek, Inwoo; Lee, Yung Mi; Baek, Kiwoon; Ko, GwangPyo

doi:10.1099/ijsem.0.003443

Cited by 23 publications

(11 citation statements)

References 31 publications

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“…Consistent with a potentially beneficial role, Erysipelotrichaceae CCMM was associated with increased motor and cognitive function and decreased EDSS and fatigue. The sequence of the V4 region of the 16S rRNA from Erysipelotrichaceae CCMM in our study was identical to 2 recently described bacteria, Faecalibacillus intestinalis and Faecalibacillus faecis 49 . Little is known about the functions of these bacteria in neurologic or autoimmune disease.…”

Section: Discussionsupporting

confidence: 73%

“…The sequence of the V4 region of the 16S rRNA from Erysipelotrichaceae CCMM in our study was identical to 2 recently described bacteria, Faecalibacillus intestinalis and Faecalibacillus faecis. 49 Little is known about the functions of these bacteria in neurologic or autoimmune disease. R lactatiformans was increased in RRMS versus HC and increased even further in progressive MS versus both RRMS and HCs.…”

Section: Discussionmentioning

confidence: 99%

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Gut Microbiome in Progressive Multiple Sclerosis

Cox

Maghzi

Liu

et al. 2021

Annals of Neurology

167

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Objective This study was undertaken to investigate the gut microbiome in progressive multiple sclerosis (MS) and how it relates to clinical disease. Methods We sequenced the microbiota from healthy controls and relapsing–remitting MS (RRMS) and progressive MS patients and correlated the levels of bacteria with clinical features of disease, including Expanded Disability Status Scale (EDSS), quality of life, and brain magnetic resonance imaging lesions/atrophy. We colonized mice with MS‐derived Akkermansia and induced experimental autoimmune encephalomyelitis (EAE). Results Microbiota β‐diversity differed between MS patients and controls but did not differ between RRMS and progressive MS or differ based on disease‐modifying therapies. Disease status had the greatest effect on the microbiome β‐diversity, followed by body mass index, race, and sex. In both progressive MS and RRMS, we found increased Clostridium bolteae, Ruthenibacterium lactatiformans, and Akkermansia and decreased Blautia wexlerae, Dorea formicigenerans, and Erysipelotrichaceae CCMM. Unique to progressive MS, we found elevated Enterobacteriaceae and Clostridium g24 FCEY and decreased Blautia and Agathobaculum. Several Clostridium species were associated with higher EDSS and fatigue scores. Contrary to the view that elevated Akkermansia in MS has a detrimental role, we found that Akkermansia was linked to lower disability, suggesting a beneficial role. Consistent with this, we found that Akkermansia isolated from MS patients ameliorated EAE, which was linked to a reduction in RORγt+ and IL‐17–producing γδ T cells. Interpretation Whereas some microbiota alterations are shared in relapsing and progressive MS, we identified unique bacteria associated with progressive MS and clinical measures of disease. Furthermore, elevated Akkermansia in MS may be a compensatory beneficial response in the MS microbiome. ANN NEUROL 2021;89:1195–1211

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Gut Microbiome in Progressive Multiple Sclerosis

Cox

Maghzi

Liu

et al. 2021

Annals of Neurology

167

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“…Faecalibacillus is a Gram-positive genus [ 44 ], first isolated from healthy South Korean subjects[ 45 ]. Due to the novelty of this genus and lack of phenotypic characterisation it was not included in the latest SILVA database, from which we assigned taxonomic ranks [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome diversity and composition is associated with hypertension in women

Louca

Nogal

Wells

et al. 2021

Journal of Hypertension

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Objectives Animal studies support a role for the gut microbiota in hypertension development, but large human studies are lacking. Here we investigated the relationship between hypertension prevalence and gut microbial composition in two cohorts. Methods We included 871 unrelated TwinsUK females with faecal microbiome data (16s rRNA gene sequencing). Multivariable linear models adjusted for age, age 2 and BMI as well as MiRKAT models, were used to estimate the association of hypertension with alpha- and beta-diversity metrics. To identify taxa associated with hypertension, a generalized additive model for location scale and shape was computed adjusting for covariates and multiple testing. Results were replicated in 448 women from PREDICT-1 Results We found that measures of alpha diversity are significantly lower in hypertensive cases (Beta[95%CI] = -0.05[-0.095, -0.004], p=0.03) and a significant association between beta diversity and hypertension (FDR < 0.05). We identified and replicated 2 genera associated with hypertension. The genus, Ruminiclostridium 6 was less abundant in hypertension cases (meta-analysis[95%CI] = -0.31[-0.5; -0.13], p = 1x10 -3 ). The uncultured microbe Erysipelotrichacea-UCG003 was more abundant in hypertensive cases (meta-analysis[95%CI] = 0.46[0.3, 0.62], p=1x10 -4 ). We genomically analysed the 16s rRNA sequence and established a 100% identity match with the 16s rRNA sequence of the genus Faecalibacillus . We functionally annotated Ruminiclostridium , identifying 83 metabolic pathways, including pathways previously linked to blood pressure regulation. Conclusion In this large human observation, we show that gut microbiome diversity and composition are associated with hypertension. Our results suggest that targeting the microbiome may be a novel means to prevent or treat hypertension.

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“…The family Erysipelotrichaceae, proposed by Verbarg et al [1], now comprises 25 genera (https://lpsn.dsmz.de/family/erysipelotrichaceae). The species listed in the family Erysipelotrichaceae are generally characterized to be Gram-stain-variable, non-sporeforming, rod-shaped, straight or slightly curved, or irregularly shaped, facultatively anaerobic, anaerobic or microaerophilic, and catalase-negative [2][3][4][5][6][7][8][9][10][11][12][13][14]. Most of the species in the family Erysipelotrichaceae can be isolated from human and animal intestine, such as canine faeces [2,3], pig intestine [4][5][6], murine intestine [7][8][9], chicken caecum [10] and human excrement [11][12][13][14].…”

mentioning

confidence: 99%

Copranaerobaculum intestinale gen. nov., sp. nov., a novel anaerobic bacterium isolated from human faeces

Feng

Chang

et al. 2022

International Journal of Systematic and Evolutionary Microbiology

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A novel obligate anaerobic organism, designated DONG20-135T, was isolated from human faeces collected in Beijing, PR China. Cells were Gram-stain-negative, rod-shaped, non-motile and non-spore-forming. Growth occurred at 25‒45 °C (optimum, 30‒35 °C), a pH range of 6–9 (optimum, pH 8) and in the presence of 0‒3.5 % (w/v) NaCl (optimum, 0.5‒1.5 %). The major fatty acids were C16 : 0, C18 : 1 ω9c and C10 : 0, the polar lipid profile consisted of diphosphatidylglycerol, phosphatidylglycerol, four glycolipids, six aminolipids, three aminophospholipids and four unidentified lipids. No respiratory quinones were detected. The cell-wall peptidoglycan of the strain was A1γ type, containing meso-diaminopimelic acid. The 16S rRNA gene sequences shared a lower identity (<92.7 % similarity) with the described species. The phylogenetic tree based on 16S rRNA gene sequences and the protein-concatamer tree showed that strain DONG20-135T formed a distinct lineage within the family Erysipelotrichaceae . The genomic DNA G + C content was 42.2 mol%. Based on the results of phenotypic, chemotaxonomic and genomic analyses, strain DONG20-135T represents a novel genus of the family Erysipelotrichaceae , for which the name Copranaerobaculum intestinale gen. nov., sp. nov. is proposed (=KCTC 15868T=CGMCC 1.17357T).

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Faecalibacillus intestinalis gen. nov., sp. nov. and Faecalibacillus faecis sp. nov., isolated from human faeces

Cited by 23 publications

References 31 publications

Gut Microbiome in Progressive Multiple Sclerosis

Gut Microbiome in Progressive Multiple Sclerosis

Gut microbiome diversity and composition is associated with hypertension in women

Copranaerobaculum intestinale gen. nov., sp. nov., a novel anaerobic bacterium isolated from human faeces

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