Failure of Active Immunization Against Trichophyton Gypseum Infection in Guinea Pigs*†

Reiss, Frederick; Leonard, Louise

doi:10.1038/jid.1956.60

Cited by 8 publications

(4 citation statements)

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“…Apart from the nature of the antigens, the route of administration may have substantial importance on the type or degree of immunity conferred. Intramuscular, subcutaneous and intradermal routes were reported and all were shown to induce some degree of immunity 34–37 . The intradermal route is empirically considered more appropriate by some authors.…”

Section: Discussionmentioning

confidence: 99%

“…Intramuscular, subcutaneous and intradermal routes were reported and all were shown to induce some degree of immunity. [34][35][36][37] The intradermal route is empirically considered more appropriate by some authors. 12,38 They argue that this route might represent an exposure to fungal antigens mimicking that produced during a natural infection.…”

Section: Discussionmentioning

confidence: 99%

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A recombinant 31.5 kDa keratinase and a crude exo‐antigen fromMicrosporum canisfail to protect against a homologous experimental infection in guinea pigs

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Brouta

Vermout

et al. 2003

Veterinary Dermatology

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A Microsporum canis recombinant 31.5 kDa keratinase and a M. canis crude exo-antigen were tested as vaccines in an experimental infection model in guinea pigs. Animals were vaccinated subcutaneously three times at two-week intervals with either the keratinase, the exo-antigen or the adjuvant alone. Cutaneous challenge was performed blindly. Both humoral and cellular-specific immune responses to M. canis antigens were evaluated every 14 days, while a blind evaluation of clinical lesion development and fungal persistency in skin were monitored weekly. Vaccination induced very high and significant (P < 0.01) antibody responses towards both antigens. High cell-mediated immune responses to both immunogens were also induced by vaccination. After challenge, however, scores reflecting the severity of dermatophytic lesions did not differ significantly between vaccinated and control groups at any time after challenge. These results suggest that, in the guinea pig, the induction of specific immune responses against the M. canis-secreted antigens used in this study are not protective against challenge exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A recombinant 31.5 kDa keratinase and a crude exo‐antigen fromMicrosporum canisfail to protect against a homologous experimental infection in guinea pigs

Descamps

Brouta

Vermout

et al. 2003

Veterinary Dermatology

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show abstract

“…It is possible that the route of administration of a dermatophyte vaccine may have substantial influence on the type or degree of immunity conferred. Intramuscular (15,31), subcutaneous (25,32,33), and intradermal (26,32) routes of vaccine administration have been reported, and all routes have been shown to induce some degree of immunity. A review of the literature reveals that there has been little systematic comparison of the immune response produced by different routes of inoculation.…”

Section: Discussionmentioning

confidence: 99%

The Immune Response toMicrosporum canisInduced by a Fungal Cell Wall Vaccine*

DeBoer

Moriello

1994

Veterinary Dermatology

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An experimental infection model was used to assess induction of specific immunity against Microsporum canis in cats with an M . canis cell wall vaccine preparation. Kittens 8-9 weeks old (n = 12) received five doses of either vaccine or placebo at biweekly intervals. Specific immunity was monitored via plasma anti-dermatophyte antibody titers and lymphocyte blastogenesis (LB) to dermatophyte antigens. After vaccination, cats were chauenged with viable M . canis spores, and lesion development was monitored. Vaccinated cats developed higher anti-dermatophyte IgG, but not IgM, titers than controls, beginning after the second dose of vaccine (P < 0.001). During the vaccination period, specific cellular immunity as measured by LB was absent in control cats, but developed to a limited degree in vaccinated cats (P < 0.05).After challenge with lo5 fungal spores per cat, both control and vaccinated cats developed active infections.The vaccine appeared to induce an antibody titer quantitatively similar to that produced by infection, but less measured cellular immunity than was seen with infection and recovery. These results suggest that induction of high titers of serum IgG or IgM antibody against Microsporum canis is not protective against challenge exposure.

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“…Hypersensitivity and partial protection were also induced by topical application of killed mycelia (Sutter, 1917;Keeney and Huppert, 1959). Culture filtrates, even if incorporated in Freund's adjuvant, induced cutaneous hypersensitivity but no immunity to infection (Reiss and Leonard, 1956;Wharton et al, 1950).…”

Section: For Prophylaxismentioning

confidence: 95%

Immunology of Surface Fungi Dermatophytes

Grappel

1981

Immunology of Human Infection

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Failure of Active Immunization Against Trichophyton Gypseum Infection in Guinea Pigs*†

Cited by 8 publications

References 1 publication

A recombinant 31.5 kDa keratinase and a crude exo‐antigen fromMicrosporum canisfail to protect against a homologous experimental infection in guinea pigs

A recombinant 31.5 kDa keratinase and a crude exo‐antigen fromMicrosporum canisfail to protect against a homologous experimental infection in guinea pigs

The Immune Response toMicrosporum canisInduced by a Fungal Cell Wall Vaccine*

Immunology of Surface Fungi Dermatophytes

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