Failure of Beta-Adrenergic Blocking Agents to Antagonize the Hyperglycemic Effect of Epinephrine in Mice

Mennear, John H.; Spratto, George R.; Miya, Tom S.

doi:10.3181/00379727-137-35518

Cited by 6 publications

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“…Other workers found it could not be blocked by j3-adrenergic blockers (5) but was blocked by a-adrenergic blockers (2). In addition, the differences in mechanisms of hyperglycemia among different species might be significant (5,12). In fact, we have unreported data that the elevation of either plasma glucose or plasma cyclic AMP is caused mainly by the release of epinephrine from the adrenal medulla through the action of CPZ on the central nervous system.…”

Section: Resultsmentioning

confidence: 99%

“…Some workers stated that (3-adrenergic receptor might be involved in the hyperglycemia (10-12), while others reported that a-adrenergic receptor might be involved (13)(14)(15)(16)(17). These controversial results may be due to differences in experimental conditions (18,19) and in the animal species (5,12,20,21).…”

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confidence: 95%

“…Hyperglycemia due to CPZ was reported to be closely related the epinephrine release from adrenal medulla (2,(4)(5)(6)(7). Moreover an impaired peripheral utilization of glucose (2, 4), a role of the central nervous system (8) and a cor relation between the hypothermia and the hyperglycemia induced by CPZ (2) were indicated to take part in the mechanism of CPZ action.…”

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confidence: 99%

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Effects of .ALPHA.- and .BETA.-adrenergic blockers on chlorpromazine-induced elevation of plasma glucose and cyclic AMP in fed mice.

1980

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Abstract-The subcutaneous administration of chlorpromazine (CPZ) caused a dose response increase in plasma glucose and cyclic AMP levels in fed male mice. Hex amethonium abolished the elevation of both plasma glucose and cyclic AMP. Pro pranolol did not inhibit the elevation of plasma glucose but inhibited the increase of plasma cyclic AMP. In contrast, phentolamine and yohimbine completely suppressed the elevation of plasma glucose but not that of plasma cyclic AMP. These results indicate that the hyperglycemia due to CPZ was mediated through the stimulation of a-adrenoceptor and on the contrary CPZ increased plasma cyclic AMP through the stimulation of p-adrenoceptor and that the increase in plasma glucose induced by CPZ was independent of the activation of adenylate cyclase and the increased plasma cyclic AMP. In addition, in contrast to phentolamine and yohimbine, phenoxybenzamine was ineffective to prevent the hyperglycemia induced by CPZ. Moreover, a higher dose of dihydroergotamine was required to inhibit the hyperglycemia. Several mechanisms considered to be involved in CPZ-induced hyperglycemia.CPZ has been demonstrated to induce hyperglycemia in rats through the activation of a and/or (3-adrenergic receptors (2-6). Hyperglycemia due to CPZ was reported to be closely related the epinephrine release from adrenal medulla (2, 4-7). Moreover an impaired peripheral utilization of glucose (2, 4), a role of the central nervous system (8) and a cor relation between the hypothermia and the hyperglycemia induced by CPZ (2) were indicated to take part in the mechanism of CPZ action. Nevertheless the detailed mechanism of the CPZ action, particularly the participation of a and 13-adrenergic receptors has not been clearly demonstrated.We demonstrated that an administration of CPZ elevated plasma cyclic AMP levels through the stimulation of adrenergic mechanisms (9).Both catecholamines and glucagon are known to elevate plasma glucose, hepatic and plasma cyclic AMP. Glucagon increases the plasma glucose and cyclic AMP levels through the increase in hepatic cyclic AMP. On the other hand, the mechanism of catecholamine to induce hyperglycemia has not been conclusively defined. Some workers stated that (3-adrenergic receptor might be involved in the hyperglycemia (10-12), while others reported

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Effects of .ALPHA.- and .BETA.-adrenergic blockers on chlorpromazine-induced elevation of plasma glucose and cyclic AMP in fed mice.

1980

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“…There are many but conflicting reports concerning the type of adrenoceptor mediating the hyperglycaemic response to adrenaline. For example, f-adrenoceptor blocking drugs have been found to be effective in reducing adrenaline hyperglycaemia by some workers (Antonis, Clark, Hodge, Molony & Pilkington, 1967;Lundquist, 1972a;Nash & Smith, 1972;Shikama & Ui, 1975) but not by others (Mennear, Spratto & Miya, 1971;Ablad, Borjesson, Carlsson & Johnsson, 1975;Potter, Moratinos & Ellis, 1977). On the other hand a-adrenoceptor blocking drugs may also reduce the hyperglycaemic effect of adrenaline (Lundquist, 1972b;Shikama & Ui, 1975;Torella, Guigliano, Improta, Giordano, Grazioli & D'Onofrio, 1977).…”

Section: Introductionmentioning

confidence: 99%

Blockade of Adrenaline‐induced Hyperglycaemia in the Anaesthetized Cat by Continuous Infusion of Phentolamine and Propranolol

Al-Jibouri

Furman

Parratt

1980

British J Pharmacology

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1 The effects of adrenoceptor blocking drugs on the metabolic responses to adrenaline infusion (I pg kg-I minm ') have been studied in the anaesthetized, fasted cat. 2 Propranolol, in doses (0.25 or 1 mg/kg) which prevented completely adrenaline-induced tachycardia, reduced but did not abolish adrenaline-induced hyperglycaemia.3 Phentolamine infusion, at a rate (15 pg kg-' min-' after a priming dose of 2.5 mg/kg) which reversed the pressor effect of adrenaline, reduced but did not abolish adrenaline-induced hyperglycaemia.4 The continuous infusion of a combination of phentolamine (15 pg kg -' minm after a priming dose of 2.5 mg/kg) and propranolol (5 pg kg-' min-' after a priming dose of 0.25 nmg/kg) prevented completely the hyperglycaemia response to adrenaline infusion over a 6 h period. 5 The increase in blood lactate concentration produced by adrenaline was prevented completely by the combined infusion of propranolol and phentolamine but was not modified by phentolamine alone.

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Effects on the Metabolism

Ellis¹

1980

Adrenergic Activators and Inhibitors

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Failure of Beta-Adrenergic Blocking Agents to Antagonize the Hyperglycemic Effect of Epinephrine in Mice

Cited by 6 publications

References 0 publications

Effects of .ALPHA.- and .BETA.-adrenergic blockers on chlorpromazine-induced elevation of plasma glucose and cyclic AMP in fed mice.

Effects of .ALPHA.- and .BETA.-adrenergic blockers on chlorpromazine-induced elevation of plasma glucose and cyclic AMP in fed mice.

Blockade of Adrenaline‐induced Hyperglycaemia in the Anaesthetized Cat by Continuous Infusion of Phentolamine and Propranolol

Effects on the Metabolism

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