Failure of Children to Receive Penicillin by Mouth

Bergman, Abraham B.; Werner, Richard

doi:10.1056/nejm196306132682404

Cited by 337 publications

(83 citation statements)

References 12 publications

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“…Zelen (1988) (Greenberg et al, 1990) which tested beta-carotene to try and prevent recurrence of basal-cell and squamous cell cancers of the skin. Nevertheless previous studies have shown that pill counts, used alone, to monitor compliance, have been unreliable when checked by biochemical monitoring for drug or metabolite (Bergman & Werner, 1963). This was not our experience as the information obtained from pill counts has been strongly supported by the measurement of etretinate levels.…”

Section: Compliancementioning

confidence: 85%

The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial

Arnold

Browman²,

Levine³

et al. 1992

Br J Cancer

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Section: Compliancementioning

confidence: 85%

The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial

Arnold

Browman²,

Levine³

et al. 1992

Br J Cancer

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“…The use of antibiotics with a shorter, less frequent dosing to improve patient compliance should be an important consideration in this patient group (Greenberg, 1984;Cockbum et al, 1987). The relationship between compliance and duration of therapy was studied by Bergman & Werner (1963) in children with otitis media. After treatment for the first 3-5 days, non-compliance was recorded in approximately 50% of patients, this rose significantly to 71% after treatment for 6-7 days (Bergman & Werner, 1963).…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between compliance and duration of therapy was studied by Bergman & Werner (1963) in children with otitis media. After treatment for the first 3-5 days, non-compliance was recorded in approximately 50% of patients, this rose significantly to 71% after treatment for 6-7 days (Bergman & Werner, 1963). However, compliance also depends on the motivation of the mother, or other care-giver, and her perception of the severity of the child's illness (Gordis, Markowitz & Lilienfeld, 1969;Becker, Drachman & Kirscht, 1972).…”

Section: Discussionmentioning

confidence: 99%

Mnlticentre evaluation of azithromycin in comparison with co-amoxiclav for the treatment of acute otitis media in children

Schaad

1993

Journal of Antimicrobial Chemotherapy

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A total of 389 children (age 0-6-102 years) with typical signs and symptoms of acute otitis media were randomized (1:1) to treatment with either azithromycin or coamoxiclav. The dosage schedule for azithromycin was 10 mg/kg/day, in a single daily dose, administered for three days. Co-amoxiclav was given at a dose of 13-3 mg/kg (amoxycillin equivalent) tid for ten days. Patients were evaluated 4-6 days and 12-16 days after the start of therapy. A satisfactory clinical response was reported for 93-2% of the 192 evaluable azithromycin-treated patients (144 cured, 35 improved), and for 97-3% of the 189 evaluable co-amoxiclav-treated patients (148 cured, 36 improved). Six (3-0%) relapses occurred in the azithromycin group, and four (21%) in the co-amoxiclav treatment group, respectively. Side-effects were recorded in a significantly fewer number of the azithromycin patients (23 of 197; 11 -7%) compared with the co-amoxiclav patients (43 of 192; 22-4%, P < 0-02). Adverse events were mainly gastrointestinal in nature, with diarrhoea the most frequent complaint (32 cases with co-amoxiclav; five with azithromycin; P < 0-001). One patient from each group discontinued therapy because of treatment-related adverse events. Laboratory analyses (mainly haematologjcal in nature) showed abnormalities in six of 100 azithromycin patients and ten of 101 co-amoxiclav patients. It was concluded that three-day, single-dose azithromycin and ten-day tid co-amoxiclav therapy have comparable clinical efficacy in paediatric patients with acute otitis media; however, there was a lower incidence of side effects in the azithromycin group.

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“…Tests were considered positive when an inhibition halo was visible around the filter-paper strip wetted in urine. [10][11][12] Compliance with antibiotic prophylaxis in sickle cell anemia -Bitarães EL et al…”

Section: Methodsmentioning

confidence: 99%

Adesão à antibioticoterapia profilática em crianças com anemia falciforme: um estudo prospectivo

Bitarães¹,

Oliveira²,

Viana³

2008

J. Pediatr. (Rio J.)

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Objective: To prospectively assess compliance with antibiotic prophylaxis among children with sickle cell anemia.Methods: A total of 108 children (aged 3 months to 4½ years, 45% male) were recruited from the Hematology Center in Belo Horizonte, Brazil, and followed up for 15 months. Data on compliance were obtained from three interviews with the primary caregivers, from the children's medical records and from assay of antibacterial activity in urine samples of 81 children. Antibiotics were available free of charge.Results: Penicillin was used in 106 cases (majority by oral route); erythromycin in 2 cases. Urine samples tested positive for the antibiotic in 56% of the cases; 48% of the caregivers assured during interviews that all doses had been administered to children; 89% of medical files recorded no compliance failures. Considering a child compliant if none or just one of these methods detected missing doses, the rate of compliance was 67%. The agreement between methods for assigning a child as compliant or not was low. No significant association of compliance rate with gender, nutritional status, per capita income of the family, caregivers' schooling, or number of family members was demonstrated. Conclusions:Compliance rate with prophylactic antibiotic therapy was low when assessed by interviews and urine tests and overestimated by analysis of medical records. Compliance should preferably be assessed by several methods due to the complex character of its measurement. The results of the present study suggest the need for a comprehensive educational program involving healthcare professionals, families and children with sickle cell anemia.J Pediatr (Rio J). 2008;84(4):316-322: Sickle cell anemia, antibiotic prophylaxis, treatment refusal, guideline adherence, penicillin V.

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Failure of Children to Receive Penicillin by Mouth

Cited by 337 publications

References 12 publications

The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial

The effect of the synthetic retinoid etretinate on sputum cytology: results from a randomised trial

Mnlticentre evaluation of azithromycin in comparison with co-amoxiclav for the treatment of acute otitis media in children

Adesão à antibioticoterapia profilática em crianças com anemia falciforme: um estudo prospectivo

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